Effect of Gmelina arborea Roxb in experimentally induced inflammation and nociception

Kulkarni, Yogesh A.; Panjabi, Ritesh; Patel, Vishvas; Tawade, Aditi; Gokhale, A.B.

doi:10.4103/0975-9476.118697

Cited by 28 publications

(21 citation statements)

References 27 publications

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“…The inactivity of the 100 mg and 200 mg observed in both extracts could be attributed to their uncharacteristic inactivity at the supraspinal level which is suggested to be common for the paw licking [32]. Earlier study has shown that G. arborea bark ethyl acetate and methanol extracts at a dose of 500 mg/kg body displayed anti-nociceptive activity from which also agrees with our present study at the dose of 400 mg/kg body weight [1]. This study suggests that the analgesic activity of GAF and GASB at 100, 200 and 400 mg may be involved in the the peripheral pain mechanism or may be through inhibition of prostaglandin activities or synthesis.…”

Section: Discussionsupporting

confidence: 91%

“…In the hot plate model, increase in the pain reaction time (latency period) indicates the level of analgesia induced by the drug or extract [30]. The hot plate test is valuable as it examines central analgesic activity due to sensitivity to strong analgesics and partial tissue damage [1]. G. arborea methanolic extracts produced a dose dependent and significant (p<0.001) increase in pain threshold in the rats mice in this models that was comparable to the reference drug ASA.…”

Section: Discussionmentioning

confidence: 99%

“…Fruit size is drup 2.25 cm long and contains 1-4 seeds. Literature information has shown extracts of G. arborea exhibited anti-inflammation [1], antihypertensive effect [2], anti-oxidative stress [3], antibacterial, antioxidant [4,5] and antidiabetic [5,6] activities. In addition, the immunostimulant potential of extract of G. arborea has been reported [7].…”

Section: Introductionmentioning

confidence: 99%

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Anti-nociceptive and Anti-inflammatory Effects of Gmelina arborea Roxb. e x. Sm.

Adebayo¹

2018

Invest Med Chem Pharmacol

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Background: The aim of the present study was to evaluate the anti-inflammatory and anti-nociceptive activities of the methanolic extract of Gmelina arborea fruit (GAF) and stem bark (GASB) on egg-albumin induced inflammation and heated plate metal respectively. Methods: 500 g of each of the pulverised samples was extracted with 90% methanol using soxhlet extractor to produce dense mass of methanolic extracts after distillation and kept in a refrigerator at 4 o C until further analysis. The anti-inflammatory activity was determined on fresh egg albumins over 4 h by measurement of rat paw oedema according to established procedure. The anti-nociceptive was evaluated by placing each rat on the heated metal plate (Hot plate) maintained at the temperature of about 50-55 0 C within the restraining plastic cylinder while animals responses were taken over 90 min. Results: Methanolic extracts of G. arborea yielded blackish thick mass and greenish paste viscous extract for the GASB and GAF respectively with percentage yields of 28% and 30% respectively. The yield revealed more extractives in the GAF than GASB. The anti-nociceptive properties of both GAF and GASB shows a relatively time dependent activity as rate of inhibition was high at the 30 th min (at the peak of p<0.001) for all doses except for 100 mg/kg per oral for the GAF. At increased time, the activity of most of the extracts reduced considerably. The eggalbumin induced inflammation was inhibited by the extracts as well in different doses. There were considerable inhibition for the GAF as well as the GASB at a minimum significant value of p<0.05 from the 1 st h to the 4 th h with maximum percentage inhibition (PI) values ranging between 30% to a peak of 70% when compared to the control. The methanolic extract of G. arborea fruit and stem bark showed significant (p<0.05) anti-inflammatory activity. Conclusions: This study has shown that GASB and GAF displayed significant anti-inflammatory effect on paw oedema induced by egg-albumin by inhibiting the release of mediators for the entire 4 h experimental period. The anti-nociceptive actions were also significant when compared with the control.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-nociceptive and Anti-inflammatory Effects of Gmelina arborea Roxb. e x. Sm.

Adebayo¹

2018

Invest Med Chem Pharmacol

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“…Filtrate obtained in this step was mixed with the filtrate obtained in first step. The extract was concentrated on a water bath and was stored in a refrigerator until further use [15].…”

Section: Preparation Of Extractmentioning

confidence: 99%

Bauhinia variegata (Caesalpiniaceae) leaf extract: An effective treatment option in type I and type II diabetes

Kulkarni

Garud

2016

Biomedicine & Pharmacotherapy

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“…ex Kurz) 28 , Gambhari (Gmelina arborea Roxb.) 29 , Bruhati (Solanum nigrum L.) 25 , Kantakari (Solanum xanthocarpum Schrad. & H.…”

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Effectiveness of Ayurveda Treatment Modalities in the Management of Spasticity in Children With Cerebral Palsy at a Tertiary Care Teaching Hospital of Southern India

Gr¹,

Shailaja²,

Rao³

et al. 2018

Int. J. Res. Ayurveda Pharm.

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To assess and compare the effectiveness of Salavana Upanaha Sweda with and without Parisheka on spasticity in children with cerebral palsy. 32 diagnosed cases of Spastic Cerebral Palsy were selected for the study based on the diagnostic criteria and inclusion criteria, later divided into two groups (A and B). The subjects in group A was administered both Parisheka and Upanaha while those in group B with Upanaha only. The duration of study was 90 days, in consecutive 3 sittings of 15 days each with gap of another 15days. Both the groups showed effect in reducing Spasticity at the level of p<0.05. Even though both groups were found to be effective in reducing Spasticity based on objective and subjective parameters, better effect was seen in Upanaha along with Parisheka group when compared to the Upanaha alone group.

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Effect of Gmelina arborea Roxb in experimentally induced inflammation and nociception

Cited by 28 publications

References 27 publications

Anti-nociceptive and Anti-inflammatory Effects of Gmelina arborea Roxb. e x. Sm.

Anti-nociceptive and Anti-inflammatory Effects of Gmelina arborea Roxb. e x. Sm.

Bauhinia variegata (Caesalpiniaceae) leaf extract: An effective treatment option in type I and type II diabetes

Effectiveness of Ayurveda Treatment Modalities in the Management of Spasticity in Children With Cerebral Palsy at a Tertiary Care Teaching Hospital of Southern India

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