Effect of gonadotropin treatment on estrus, ovulation, and litter size in weaned and anestrous sows1

Manjarín, Rodrigo; Garcia, José Carlos; Domínguez, Juan Carlos Castillo; Castro, M.J.; Alegre, B.; Muñoz, Jaime Eduardo; Kirkwood, R. N.

doi:10.2527/jas.2009-2792

Cited by 13 publications

(8 citation statements)

References 20 publications

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“…This would be consistent with the results of Manjarin et al [34] and Patterson et al [5]. More piglets were born to gilts and primiparous sows treated with PMSG than to untreated animals or animals injected with peforelin.…”

Section: Paritysupporting

confidence: 93%

Effect of a GnRH analogue (Maprelin) on the reproductive performance of gilts and sows

Jong

Kauffold²,

Engl³

et al. 2013

Theriogenology

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a b s t r a c tThe ability of peforelin (l-GnRH-III) to stimulate follicular growth, FSH release, and estrus in gilts after altrenogest treatment and in sows after weaning was investigated. In three farrow-to-wean herds, with at least 600 sows and average production performance, 216 gilts, 335 primiparous, and 1299 pluriparous sows were randomly allocated to three treatments: peforelin (M group: Maprelin), eCG (F group: Folligon), and physiological saline solution (C group). Animals were treated 48 hours after their last altrenogest treatment (gilts) or 24 hours after weaning (sows). The weaning-to-estrus interval, estrus duration, estrus rate (ER), pregnancy rate, and total born (TB), live born, and stillborn (SB) numbers were recorded and compared between treatments for the different parity groups (gilts and primiparous and pluriparous sows). Follicle sizes were measured in representative animals from each group on the occasion of their last altrenogest treatment or at weaning, and also on the occasions of their first (FS1) and second (FS2) attempted inseminations. Blood samples were taken to determine FSH concentrations at weaning and 2 hours after injection, and progesterone concentrations 10 days after the first insemination attempt. The relative change in FSH concentrations was calculated. Significant differences were found for ER within 7 days of weaning in pluriparous sows (95%, 91%, and 90% for the M, F, and C groups, respectively, P ¼ 0.005). Gilts in the F-group had high TB numbers, and pluriparous sows in the M group had high SB numbers (TB gilts ¼ 13.6, 15.4, and 14.9 [P ¼ 0.02] and SB pluriparous sows ¼ 1.8, 1.4, and 1.7 [P ¼ 0.05] for the M, F, and C groups, respectively). The M group had the highest FS1 (for gilts) and FS2 (for pluriparous sows) values: FS1 ¼ 5.4, 4.9, and 4.9 mm [P ¼ 0.02] and FS2 ¼ 6.8, 5.3, and 6.3 mm [P ¼ 0.03] for the M, F, and C groups, respectively. There were no significant differences between the different treatments within each parity group with respect to any of the other variables. Overall, peforelin treatment had small but positive effects on the ER and follicle growth in certain parity groups but did not seem to affect litter sizes or FSH and progesterone levels in sows on the occasions of the corresponding examinations.

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Section: Paritysupporting

confidence: 93%

Effect of a GnRH analogue (Maprelin) on the reproductive performance of gilts and sows

Jong

Kauffold²,

Engl³

et al. 2013

Theriogenology

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“…Treatment with eCG in gilts and younger sows could thus have more influence on the outcome of total born piglets, compared to the litter size in older sows. The lack of significant differences with respect to litter size among the control and treatment groups in sows is consistent with the results of earlier studies [22, 23]. do Lago et al (2005) and Martinat-Botté et al (2010) found that eCG treatment increased the ovulation rate [2, 24], leading to larger litter sizes.…”

Section: Discussionsupporting

confidence: 90%

“…The effect of treatment with supplemental LH-like activity products (such as eCG) was shown to be age dependent [22]. Therefore it is possible that the endogenous LH support of older sows is adequate enough to support follicular development, whereas that of gilts is maybe insufficient.…”

Section: Discussionmentioning

confidence: 99%

Effect of a GnRH analogue (peforelin) on the litter performance of gilts and sows

Jong

Jourquin

Kauffold³

et al. 2017

Porc Health Manag

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BackgroundMaintaining optimal reproductive and litter performance is essential for meeting economic targets in commercial pig production. Treatment with exogenous gonadotropins in sows after weaning or in gilts after altrenogest treatment has been used to stimulate follicular development leading to more piglets born and eventually higher birth weights. The effect of peforelin on litter performance was investigated in 212 gilts, primi- and pluriparous sows in three herds. Animals were randomly allocated to three treatments 24 h after weaning: peforelin (P group), eCG (E group), and physiological saline solution (C group). Numbers of total, liveborn and stillborn piglets and mortality rate during lactation were recorded. Birth weights and coefficient of variation in weights within litter were assessed. All parameters were compared among treatments.ResultsOver all parities, no difference was found among treatments in litter size nor mortality rate, but birth weights were significantly lower in the E group. Stillbirth numbers in pluriparous sows were 2.2, 0.9 and 1.4 for P, E and C groups, respectively (p = 0.04). Piglets in the P group had significantly higher live born birth weights in gilts, compared to the E group (1.36, 1.26, 1.32 kg (p < 0.02) for P, E and C group, respectively). No significant differences were found for the other investigated parameters.ConclusionsPeforelin treatment showed no improvement of litter performance compared to no treatment.

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“…No significant difference in FEI throughout the different study periods could be observed, although numerical trends showed an improvement in all study periods. This indicates that GnRH-agonists have little influence on the outcome of pregnancy [19, 23] and mainly improve estrus performance. An increase of almost 9 % in FEI may have a significant biological impact on sow farm management, especially under conditions of batch management systems, where return-to-estrus and non-pregnancy can have a major impact on the batch stability.…”

Section: Resultsmentioning

confidence: 99%

An evaluation of gonadotropin-releasing hormone analogue administered to gilts and sows on subsequent reproductive performance and piglet birth weight

Vangroenweghe¹,

Goossens²,

Jourquin³

2016

Porc Health Manag

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BackgroundThe present study investigated the effect of peforelin (Maprelin®), a gonadotropin-releasing hormone (GnRH) analogue, administration in gilts, primiparous and pluriparous sows in a high productive farm on sow reproductive performance and piglet quality at birth.MethodsIn a 400 sow herd, gilts, primiparous and pluriparous sows were randomly allocated to 2 groups: peforelin treated (peforelin = P-group) or no treatment (control = C-group). Animals were injected 48 h after the last altrenogest treatment (gilts) or 24 h post weaning (sows). Weaning-to-estrus interval (WEI), estrus rate (ER), farrowing efficiency index (FEI), farrowing rate (FR), number of total (TBP), live (LBP) and stillborn piglets (SBP), mummies (MM) and live piglet index (LPI) were assessed and compared between treatment groups. To assess piglet quality at birth, 6033 piglets from 426 litters were weighed individually within 24 h after birth (BW; birth weight).ResultsNo significant difference between treatment groups could be observed for WEI, TBP, LBP, SBP and MM. The ER was significantly (P = 0.0119) higher (93.2 %) in the P-group as compared to the C-group (87.2 %). Peforelin treatment did not affect farrowing rate. Both FEI and LPI were significantly (P = 0.0078) better in the P-group as compared to the C-group. Overall, no effect of peforelin treatment on piglet birth weight could be observed, although specific subcategories (1st parity and older (5+ parity) sows) did have a significant impact of treatment on birth weight. During late summer (August-September) all treated gilts and sows took advantage from peforelin treatment with a significant improvement of piglet birth weight.ConclusionPeforelin treatment had a significant impact on ER, FEI and LPI. Moreover, piglet birth weight improved for specific sow subcategories (1st parity and older sows) and for all gilts and sows during the late summer infertility period.

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Effect of gonadotropin treatment on estrus, ovulation, and litter size in weaned and anestrous sows1

Cited by 13 publications

References 20 publications

Effect of a GnRH analogue (Maprelin) on the reproductive performance of gilts and sows

Effect of a GnRH analogue (Maprelin) on the reproductive performance of gilts and sows

Effect of a GnRH analogue (peforelin) on the litter performance of gilts and sows

An evaluation of gonadotropin-releasing hormone analogue administered to gilts and sows on subsequent reproductive performance and piglet birth weight

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