Effect of goniothalamin on the development of Ehrlich solid tumor in mice

Vendramini–Costa, Débora Barbosa; Castro, Ilton Barros Daltro de; Ruiz, Ana Lúcia Tasca Góis; Marquissolo, Cilene; Pilli, Ronaldo A.; Carvalho, João Ernesto de

doi:10.1016/j.bmc.2010.07.053

Cited by 61 publications

(68 citation statements)

References 28 publications

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“…Also, other studies demonstrated pro-apoptotic activity of the R-GTN by means of caspases pathway; increase of BAX pro-apoptotic protein expression; and inhibition of nitric oxide synthase (NOS) (Inayat-Hussain et al 2003, de Fatima et al 2005. Vendramini-Costa et al (2010) verified that racGTN, the same used in the study herein, showed antiedematogenic activity with simultaneous tumoral development inhibition in the solid tumor of Ehrlich. The same authors observed similar action between racGTN and the Piroxicam, nonsteroidal and anti-inflammatory, by means of significant inhibition of the inflammatory edema in an Ehrlich tumor.…”

Section: Discussionsupporting

confidence: 74%

“…Celecoxib was obtained from CELEBRA (Pfizer Pharmaceuticals LLC, Caguas, Puerto Rico), and diluted in CMC 0.05% (Sozer et al 2011). The acute toxicity of GTN has been evaluated in a previous study (Vendramini-Costa et al 2010).…”

Section: Drugsmentioning

confidence: 99%

“…According to Vendramini-Costa et al (2010) both enantiomerically pure (R) and racemic (racGTN) forms showed antiproliferative features in an Ehrlich solid tumor model mice.…”

Section: Introductionmentioning

confidence: 99%

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Anti-inflammatory therapies in TRAMP mice: delay in PCa progression

Kido¹,

Montico²,

Sauce³

et al. 2016

Endocrine-Related Cancer

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The aim of this study was to characterize the structural and molecular biology as well as evaluate the immediate and late responses of prostatic cancer in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model after treatment with goniothalamin (GTN) and celecoxib. The treated mice received GTN (150 mg/kg, gavage) or celecoxib (10 mg/kg, gavage) from 8 to 12 weeks of age. They were killed at different ages: the immediate-response groups at 12 weeks and the late-response groups at 22 weeks. The ventral prostate was collected for light microscopy, immunohistochemistry, western blotting, TUNEL, and ELISA. Morphological analyses indicated that GTN treatment delayed the progression of prostatic adenocarcinoma, leading to a significant decrease of prostatic lesion frequency in both experimental period responses to this treatment, mainly high-grade prostatic intraepithelial neoplasia and well-differentiated adenocarcinoma. Also, the celecoxib treatment showed a particular decrease in the proliferative processes (PCNA) in both the experimental periods. Despite celecoxib diminishing the COX2 and IGFR1 levels, GTN presented higher action spectrum considering the decrease of a greater molecular number involved in the proliferative and inflammatory processes in prostatic cancer. Goniothalamin attenuated the pro-inflammatory response in TRAMP prostatic microenvironment, delaying prostate cancer (PCa) progression. Celecoxib treatment was efficient in the regulation of COX2 in the TRAMP mice, mainly in the advanced disease grade. Finally, we concluded that inflammatory process control in early grades of PCa was crucial for the downregulation of the signaling pathways involved in the proliferative processes in advanced cancer grades.

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Section: Discussionsupporting

confidence: 74%

Section: Drugsmentioning

confidence: 99%

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Anti-inflammatory therapies in TRAMP mice: delay in PCa progression

Kido¹,

Montico²,

Sauce³

et al. 2016

Endocrine-Related Cancer

Self Cite

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“…Goniothalamin is a promising antitumor agent against cancerous cell lines (Wattanapiromsakul et al, 2005). On the other hand a study by Vendramini-Costa et al , 2010 demonstrated that the antiproliferative activity of goniothalamin in some solid tumor experimental model with no evidence of toxic effects in the animals after single and repeated doses.…”

Section: Introductionmentioning

confidence: 99%

Induction of Caspase-9, Biochemical Assessment and Morphological Changes Caused by Apoptosis in Cancer Cells Treated with Goniothalamin Extracted from Goniothalamus macrophyllus

Alabsi¹,

Ali²,

Ali³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…e dose used to test the antitumor activity of the extracts was 10% of the LD 50 ; at these doses, no histological changes were observed in mice treated for seven days. So, these doses were considered safe for use in the following in vivo experiments [18].…”

Section: Column 3: Hexanic Extractsmentioning

confidence: 99%

Antitumor Activity of Leaves from Hyptis mutabilis (A. Rich.) Briq. (Lamiaceae) in Mice Bearing Tumor

Ximenes

Melo

Magalhães

et al. 2013

Dataset Papers in Pharmacology

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e Hyptis genus has more than 400 species, many of them being used in folk medicine to treat several conditions. Some anticancer compounds have been isolated from plants of this genus, and for that reason we decided to investigate the potential in vivo antitumor activity of extracts of leaves of Hyptis mutabilis with different polarities (hexane, methanol, water, and hot water) against two mice tumors: sarcoma 180 and Ehrlich solid tumor. Phytochemical analysis revealed strong presence of steroids, saponins, �avonoids (mainly dihydro�avanols), and catechins. Acute toxicity was perfomed according to the up-and-down method showing LD 50 values ranging from 100 up to 2500 mg/kg. Antitumor activity was investigated using 10% of the LD 50 for each extract. Methotrexate was used as positive control. Both aqueous extracts showed strong inhibition of tumor growth with values up to 70% of inhibition growth for sarcoma 180. Ehrlich solid tumor was only slight inhibited by hexane extract (38.6%). In conclusion, the aqueous extracts of H. mutabilis showed promising results against sarcoma 180 mice tumor.

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Effect of goniothalamin on the development of Ehrlich solid tumor in mice

Cited by 61 publications

References 28 publications

Anti-inflammatory therapies in TRAMP mice: delay in PCa progression

Anti-inflammatory therapies in TRAMP mice: delay in PCa progression

Induction of Caspase-9, Biochemical Assessment and Morphological Changes Caused by Apoptosis in Cancer Cells Treated with Goniothalamin Extracted from Goniothalamus macrophyllus

Antitumor Activity of Leaves from Hyptis mutabilis (A. Rich.) Briq. (Lamiaceae) in Mice Bearing Tumor

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