Effect of gossypol on blood serum parameters and small intestinal morphology of male broilers

Özdoğan, Mürsel; Wellmann, Kimberly B; Paksuz, Emine Pınar

doi:10.1111/j.1439-0396.2010.01126.x

Cited by 19 publications

(7 citation statements)

References 27 publications

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“…No significant differences in severity scores were reported in channel catfish fed diets containing up to 1,500 mg gossypol/kg diets (12). Similarly, no clear negative effects were found on small intestine morphology in male broilers fed up to 186 mg gossypol/kg diets (50). All these results suggested that gossypol had minimal influences on digestive tract.…”

Section: Discussionmentioning

confidence: 85%

Dietary gossypol suppressed postprandial TOR signaling and elevated ER stress pathways in turbot (Scophthalmus maximus L.)

Bian

Jiang

Man

et al. 2017

American Journal of Physiology-Endocrinology and Metabolism

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Gossypol is known to be a polyphenolic compound toxic to animals. However, its molecular targets are far from fully characterized. To evaluate the physiological and molecular effects of gossypol, we chose turbot (Scophthalmus maximus L.), a carnivorous fish, as our model species. Juvenile turbots (7.83 ± 0.02 g) were fed diets containing gradient levels of gossypol at 0 (G0), 600 (G1), and 1,200 (G2) mg/kg diets for 11 wk. After the feeding trial, fish growth, body protein, and fat contents were significantly reduced in the G2 group compared with those of the G0 group (P < 0.05). Gossypol had little impact on digestive enzyme activities and intestine morphology. However, gossypol caused liver fibrosis and stimulated chemokine and proinflammatory cytokine secretions. More importantly, gossypol suppressed target of rapamycin (TOR) signaling and induced endoplasmic reticulum (ER) stress pathway in both the feeding experiment and cell cultures. Our results demonstrated that gossypol inhibited TOR signaling and elevated ER stress pathways both in vivo and in vitro, thus providing new mechanism of action of gossypol in nutritional physiology.

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Section: Discussionmentioning

confidence: 85%

Dietary gossypol suppressed postprandial TOR signaling and elevated ER stress pathways in turbot (Scophthalmus maximus L.)

Bian

Jiang

Man

et al. 2017

American Journal of Physiology-Endocrinology and Metabolism

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“…Histological indices were measured using NIS-Elements Viewer software (Version: 4.20; NIS Elements, Nikon, Melville, NY, USA) with an inverted microscope (Eclipse TE2000, Nikon Instruments Inc., Melville, NY, USA) using a calibrated eyepiece graticule at 4× magnification. The height and the width of 10 well-oriented villi and their associated crypts were measured from each slide according to Özdoğan et al [17]. The villus height to crypt depth ratio (V:C) was calculated.…”

Section: Sample Preparation and Laboratory Analysesmentioning

confidence: 99%

Physiological impact on layer chickens fed corn distiller’s dried grains with solubles naturally contaminated with deoxynivalenol

Wickramasuriya

Macelline

Kim

et al. 2020

Asian-Australas J Anim Sci

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Objective: An experiment was conducted to investigate the response of laying hens fed corn distiller' s dried grains with solubles (DDGS) that are naturally contaminated with deoxynivalenol (DON). Methods: One hundred and sixty 52-week-old Lohmann Brown Lite hens were randomly allotted to five dietary treatments with 8 replicates per treatment. The dietary treatments were formulated to provide a range of corn DDGS contaminated with DON from 0% to 20% (i.e., 5% scale of increment). All laying hens were subjected to the same management practices in a controlled environment. Body weight, feed intake and egg production were measured biweekly for the entire 8-week experiment. The egg quality was measured biweekly for 8 weeks. On weeks 4 and 8, visceral organ weights, blood metabolites, intestinal morphology, and blood cytokine concentrations were measured. Results: The inclusion of corn DDGS contaminated with DON in the diet did not alter (p> 0.05) the body weight, feed intake, hen-day egg production, egg mass and feed efficiency of the laying hens. No difference was found (p>0.05) in the egg quality of hens that were fed the dietary treatments. Furthermore, hens that were fed a diet containing corn DDGS contaminated with DON showed no change (p>0.05) in the visceral organ weights, the blood metabolites, and the cytokine concentrations. The crypt depth increased (p<0.05) as the amount of corn DDGS contaminated with DON increased. Proportionately, the villus height to crypt depth ratio of the laying hens decreased (p<0.05) with the increasing level of corn DDGS contaminated with DON in the diet. Conclusion:The inclusion of corn DDGS contaminated with DON up to 20% in layer diets did not cause changes in egg production performance and egg quality, which indicates that DON is less toxic at the concentration of 1.00 mg DON/kg.

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“…This finding suggests that feeding SSCSM results in improved intestinal morphology and healthier animals which can be attributed to: 1) a direct relationship between intestinal microflora and gut health. The increased LAB population could inhibit the colonization of pathogens such as coliform bacteria and reduce the incidence of their negative effects on intestinal structure and tissue, 2) the breakdown of large proteins into small peptides after SSF of cottonseed meal and 3) the reduction of free gossypol in SSCSM (Jazi et al, 2017, Özdoğan et al, 2012). The positive effects of using SSCSM as an alternative protein source is evident as it could improve gut health and performance of broiler chickens.…”

Section: Effect Of Solid-state Fermentation On the Nutrient Compositimentioning

confidence: 99%

Solid-state fermented plant protein sources in the diets of broiler chickens: A review

et al. 2019

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Protein sources are the second most important component in poultry diets. Due to the fluctuation in price of soybean meal (SBM) and persistent increase in feed prices, nutritionists have been exploring alternative protein sources. Replacement of SBM with alternative protein sources in poultry diets could reduce human-livestock competition for soybean and support the production of more animal protein. However, the use of alternative protein sources is limited to low inclusion due to the presence of anti-nutritional factors (ANF) such as glucosinolates (rapeseed meal), gossypol (cottonseed meal), non-starch polysaccharides (NSP) in lupin flour, high fibre (palm kernel cake), total phenolic contents and phytic acid (canola meal) known to impair animal performance, nutrient digestibility and feed utilization. As a processing technique, solid-state fermentation (SSF) has been researched for a long time in the food industry. An important objective of SSF is the production of enzymes, organic acids and other metabolites of economic importance. In recent times, SSF has been employed to enhance nutrient bioavailability, inhibit gut pathogenic bacteria and reduce ANF in plant protein sources resulting in improved nutrient digestibility, thereby improving performance and gut health of broiler chickens. Unlike pigs, there is still a dearth of information on feeding solid-state fermented feed ingredients to broiler chickens. This review aims to describe the nutritional value of the solid-state fermented products of rapeseed meal, canola meal, cottonseed meal, palm kernel cake and lupin flour on performance and intestinal health of broiler chickens.

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Effect of gossypol on blood serum parameters and small intestinal morphology of male broilers

Cited by 19 publications

References 27 publications

Dietary gossypol suppressed postprandial TOR signaling and elevated ER stress pathways in turbot (Scophthalmus maximus L.)

Dietary gossypol suppressed postprandial TOR signaling and elevated ER stress pathways in turbot (Scophthalmus maximus L.)

Physiological impact on layer chickens fed corn distiller’s dried grains with solubles naturally contaminated with deoxynivalenol

Solid-state fermented plant protein sources in the diets of broiler chickens: A review

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