Effect of Graft Preservation and Acute Rejection on Hypoxia-Inducible Factor-1 in Rat Cardiac Allografts

Keränen, Mikko; Nykänen, Antti; Krebs, R.; Tuuminen, Raimo; Sandelin, H.; Koskinen, Petri; Lemström, Karl

doi:10.1016/j.transproceed.2006.10.057

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…In an experimental rat model of cardiac allotransplantation HIF‐1 mRNA and protein expression increased during acute or chronic rejection (20). In our study we did not find an association between intra‐operative HIF‐1α expression and subsequent episodes of acute rejection or cardiac allograft vasculopathy.…”

Section: Discussionmentioning

confidence: 99%

Donor Myocardial HIF‐1α Is an Independent Predictor of Cardiac Allograft Dysfunction: A 7‐Year Prospective, Exploratory Study

Aharinejad

Schäfer

Krenn

et al. 2007

American Journal of Transplantation

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Knowledge on interplay between the cardiac molecular response to transplantation-induced stress and primary graft dysfunction (PGD) is limited. A cDNA array identified HIF-1, EGR-1, NAB-2, VEGF-A and uPA as mediators of cardiac tissue response to transplantationinduced stress. mRNA expression of these molecules was measured in left ventricular biopsies from 200 donors before and after aortic cross-clamping and at 10-, 30-and 60-min reperfusion by real-time RT-PCR. HIF-1a expression at two time points was significantly associated with PGD, as shown by univariate analysis, receiver operating characteristic curve and multivariate logistic regression. At a cut-off level of 200 arbitrary units, HIF-1a after aortic cross-clamping in donors (78% sensitivity, 83% specificity) and at 10-min reperfusion (85% sensitivity, 83% specificity) identified PGD. HIF-1a demonstrates the potential to be a predictive marker for PGD; however, as multiple factors were tested at different time points, prospective evaluation is clearly necessary to confirm this observation.

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Section: Discussionmentioning

confidence: 99%

Donor Myocardial HIF‐1α Is an Independent Predictor of Cardiac Allograft Dysfunction: A 7‐Year Prospective, Exploratory Study

Aharinejad

Schäfer

Krenn

et al. 2007

American Journal of Transplantation

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“…Though post-procurement continuous perfusion transport devices are being evaluated, cold ischemia is still utilized for the vast majority of cardiac transplants. Prolonged graft ischemia during preservation and ischemia-reperfusion injury activates the hypoxiainducible factor (HIF) pathway in both rodent and human cardiac transplantation [24, 37]. The activated HIF consists of an oxygen-sensitive α subunit (HIF-1α or HIF-2α) and a constitutively expressed β subunit (HIF-1β).…”

Section: The Contribution Of Phagocytes To Acute Cardiac Allograft Rementioning

confidence: 99%

Acute and chronic phagocyte determinants of cardiac allograft vasculopathy

Glinton

DeBerge

Yeap³

et al. 2018

Semin Immunopathol

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Post-transplant immunosuppression has reduced the incidence of T cell-mediated acute rejection, yet long-term cardiac graft survival rates remain a challenge. An important determinant of chronic solid organ allograft complication is accelerated vascular disease of the transplanted graft. In the case of cardiac allograft vasculopathy (CAV), the precise cellular etiology remains inadequately understood; however, histologic evidence hints at the accumulation and activation of innate phagocytes as a causal contributing factor. This includes monocytes, macrophages, and immature dendritic cell subsets. In addition to crosstalk with adaptive T and B immune cells, myeloid phagocytes secrete paracrine signals that directly activate fibroblasts and vascular smooth muscle cells, both of which contribute to fibrous intimal thickening. Though maladaptive phagocyte functions may promote CAV, directed modulation of myeloid cell function, at the molecular level, holds promise for tolerance and prolonged cardiac graft function.

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Peripheral blood transcriptome analysis and development of classification model for diagnosing antibody-mediated rejection vs accommodation in ABO-incompatible kidney transplant

Jeon

Lee

Kim

et al. 2020

American Journal of Transplantation

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Effect of Graft Preservation and Acute Rejection on Hypoxia-Inducible Factor-1 in Rat Cardiac Allografts

Cited by 3 publications

References 3 publications

Donor Myocardial HIF‐1α Is an Independent Predictor of Cardiac Allograft Dysfunction: A 7‐Year Prospective, Exploratory Study

Donor Myocardial HIF‐1α Is an Independent Predictor of Cardiac Allograft Dysfunction: A 7‐Year Prospective, Exploratory Study

Acute and chronic phagocyte determinants of cardiac allograft vasculopathy

Peripheral blood transcriptome analysis and development of classification model for diagnosing antibody-mediated rejection vs accommodation in ABO-incompatible kidney transplant

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