Effect of Grape Seed Extract on Tibial Dyschondroplasia Incidence, Liver Weight, and Tibial Angiogenesis in Chickens

Qamar, Hammad

doi:10.29261/pakvetj/2019.109

Cited by 10 publications

(6 citation statements)

References 24 publications

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“… 59 , 60 Whereas, grape seed extract, a great source of resveratrol has been also declared to possess the antioxidant and anti-inflammatory effects. 61 …”

Section: Resultsmentioning

confidence: 99%

“…59,60 Whereas, grape seed extract, a great source of resveratrol has been also declared to possess the antioxidant and anti-inflammatory effects. 61 This evidently relates the fact that how these natural compounds can help to ameliorate the metabolic impairment which are the key factors associated with prevalence and worsening of metabolic disorders. 62 Additionally, the outcomes of histological inspection of pancreas and intestine in our study were found to be in accordance with biochemical effects observed during the study period.…”

Section: Discussionmentioning

confidence: 99%

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Biochemical Investigation of Therapeutic Potentials of Plant-Based Bioactive Compounds as Stimulators of Glucagon like peptide-1 Secretion

et al. 2022

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This study was aimed to investigate the therapeutic potentials of plant-based bioactive compounds; lutein and resveratrol alone and/or in combination with DPP-4 enzyme inhibitor; sitagliptin on the secretion and bioavailability of Glucagon like peptide-1(GLP). For this, experimental rats were divided into seven groups. Group 1 was marked as control, while other six groups received streptozotocin (60 mg/kg I.P.). Later, group 2 was kept disease-control. While group 3 received 10 mg/kg/day sitagliptin (DDP-4i). Group 4 received 40 mg/kg/day lutein (LUT) and group 5 received 30 mg/kg/day resveratrol (RES). While group 6 and 7 were received combination of DPP-4i+LUT and DPP-4i+RES, respectively. Combined administration of DPP-4i+LUT or DPP-4i+RES showed expected therapeutic effects by lowering the fasting blood glucose and maintaining the serum insulin concentrations with improved glucose sensitivity and reduced insulin resistance. Further, co-administration of LUT and RES with DPP-4i revealed beneficial effects on measures of insulin resistance, circulating lipids, glycemic index, oxidative stress, and inflammatory status along with restoration of histological morphology of pancreatic cells and enterocytes that seemed to improve the level of GLP-1. Hence, substantial verdicts of this study showing therapeutic potentials of LUT and RES would surely help to recognize the potential effects in combination with DPP-4i as stimulators of GLP-1 secretion.

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“… 59 , 60 Whereas, grape seed extract, a great source of resveratrol has been also declared to possess the antioxidant and anti-inflammatory effects. 61 …”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Biochemical Investigation of Therapeutic Potentials of Plant-Based Bioactive Compounds as Stimulators of Glucagon like peptide-1 Secretion

et al. 2022

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“…Oxidative stress induces the release of Cyt-c from the mitochondria that is the key factor of apoptosis, while the antioxidant enzyme Gpx4 can eliminate lipid peroxides in the mitochondria to inhibit the production of Cyt-c and reduce apoptosis (73). DQ can also affect the caspase signal pathway by inducing oxidative stress to produce ROS and enhance the activities of caspase-3 and caspase-9 in the liver tissue (74)(75)(76)(77)(78). It is found that there is a relationship between Bax/Bcl-2 and caspase.…”

Section: Discussionmentioning

confidence: 99%

Effects of Acute Diquat Poisoning on Liver Mitochondrial Apoptosis and Autophagy in Ducks

Chen

Lin

et al. 2021

Front. Vet. Sci.

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Diquat (DQ) is an effective herbicide and is widely used in agriculture. Due to persistent and frequent applications, it can enter into aquatic ecosystem and induce toxic effects to exposed aquatic animals. The residues of DQ via food chain accumulate in different tissues of exposed animals including humans and cause adverse toxic effects. Therefore, it is crucial and important to understand the mechanisms of toxic effects of DQ in exposed animals. We used ducks as test specimens to know the effects of acute DQ poisoning on mechanisms of apoptosis and autophagy in liver tissues. Results on comparison of various indexes of visceral organs including histopathological changes, apoptosis, autophagy-related genes, and protein expression indicated the adverse effects of DQ on the liver. The results of our experimental trial showed that DQ induces non-significant toxic effects on pro-apoptotic factors like BAX, BAK1, TNF-α, caspase series, and p53. The results revealed that anti-apoptotic gene Parkin was significantly upregulated, while an upward trend was also observed for Bcl2, suggesting that involvement of the anti-apoptotic factors in ducklings plays an important role in DQ poisoning. Results showed that DQ significantly increased the protein expression level of the autophagy factor Beclin 1 in the liver. Results on key autophagy factors like LC3A, LC3B, and p62 showed an upward trend at gene level, while the protein expression level of both LC3B and p62 reduced that might be associated with process of translation affected by the pro-apoptotic components such as apoptotic protease that inhibits the occurrence of autophagy while initiating cell apoptosis. The above results indicate that DQ can induce cell autophagy and apoptosis and the exposed organism may resist the toxic effects of DQ by increasing anti-apoptotic factors.

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“…Eimeria species affect intestine of the bird and cause bloody diarrhea, poor Feed Conversion Ratio (FCR) and mortality which lead to heavy economic losses to poultry industry (Chapman, 2014;Shahid et al, 2020;Khater et al, 2020). The coccidiosis infection starts with the ingestion of sporulated oocysts by the chicken from contaminated feed and water (Qamar et al, 2020;Zhang et al, 2020). Coccidian oocysts produce millions of oocysts by asexual and sexual multiplication within the host.…”

Section: Introductionmentioning

confidence: 99%

Anticoccidial potential of Ageratum conyzoides and its effect on Blood parameters of experimentally infected Broiler Chickens

Hussain

Abbas

et al. 2021

J Hellenic Vet Med Soc

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Coccidiosis is an infectious parasitic disease of poultry which causes heavy economic losses to commercial poultry industry. Coccidiosis has been generally controlled by using different synthetic anticoccidial drugs but, due to development of resistance to these drugs this method is losing its effectiveness. Exploration of novel and alternative compounds against avian coccidiosis is need of time now a days. In this regard, medicinal plants can serve as substitute to these synthetic anticoccidials. Thus, to find out alternative novel agents, current research was designed to evaluate the anticoccidial potential of Ageratum conyzoides extract (ACE). For in vivo experiment, 105 broiler chicks were purchased and further divided into 7 sub-groups (15 birds in each group). At 7th day of experiment, Groups A, B and C were fed with plant extract at 100, 200 and 300 mg/kg respectively. Group D was supplemented with Vitamin-E while, Group E and F remained as infected medicated and infected un-medicated control groups and served with standard medicine (Baycox®) and Phosphate Buffer Saline (PBS) respectively. Moreover, Group G served as normal control group. At day 14th of experiment, all groups except rom Group G were orally infected with 60,000 sporulated oocysts of mixed Eimeria species. Anticoccidial potential of ACE was evaluated on the basis of lesion scores, fecal scores, oocyst scores and feed conversion ratio. Furthermore, the effect of ACE on the serum chemistry was also evaluated to check toxicity of plant extract if any. The results were compared with standard medicine (Baycox®). On the basis of results, ACE showed anticoccidial activity by reducing fecal, lesion and oocyst scores in infected chicks (P<0.05). ACE also improved FCR of infected chicks. Moreover, ACE exhibited positive effects on serum chemistry of broiler chickens (P<0.05).

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Effect of Grape Seed Extract on Tibial Dyschondroplasia Incidence, Liver Weight, and Tibial Angiogenesis in Chickens

Cited by 10 publications

References 24 publications

Biochemical Investigation of Therapeutic Potentials of Plant-Based Bioactive Compounds as Stimulators of Glucagon like peptide-1 Secretion

Biochemical Investigation of Therapeutic Potentials of Plant-Based Bioactive Compounds as Stimulators of Glucagon like peptide-1 Secretion

Effects of Acute Diquat Poisoning on Liver Mitochondrial Apoptosis and Autophagy in Ducks

Anticoccidial potential of Ageratum conyzoides and its effect on Blood parameters of experimentally infected Broiler Chickens

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