Effect of grape seed oil supplementation on plasma lipid profiles in rats

Kim, Dae Jung; Jeon, Geonuk; Sung, Jeehye; Oh, Sea-Kwan; Hong, Ha-Cheol; Lee, Junsoo

doi:10.1007/s10068-010-0035-9

Cited by 23 publications

(24 citation statements)

References 20 publications

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“…Furthermore, GSO improve the lipid ratios: atherogenic coefficient (AC), cardiac risk ratio (CRR), LDL-c to HDL-c ratio and atherogenic index of plasma (AIP) compared with the +ve control group. This results confirmed with Kim et al, (2010) [6], who reported that the GSO decreased serum TC, LDL-c significantly. Also, atherogenic index and HDL:TC ratio were enhanced significantly.…”

Section: Discussionsupporting

confidence: 92%

“…Several studies have shown that saturated fats increase total cholesterol (TC) and LDL-c levels in plasma, but, the dietary PUFA decrease them [6]. Grape seed oil (GSO) and its extract have been recently shown to have many health properties due to its contents of important bioactive compounds including polyphenols, flavonoids, procyanidins, proanthocyanidins, minerals and vitamins [7].…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Grape Seed Oil on Hypercholesterolemia in Rats

Mokhtar¹,

El-Banna²,

Haggag³

2016

IJNFS

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Abstract:This study was carried out to investigate that the effect of grape seed oil (GSO) on Hypercholesterolemia in rats.Thirty-five rats were divided into 5 groups, group 1 was given the basal diet as a negative control group (-ve), group 2 was given the basal diet with GSO instead of soybean oil as a negative control for GSO. Groups (3, 4 and 5) were fed on high cholesterol diet (HCD) (1% cholesterol powder and 0.5% bile salt for 8 weeks), Group 3 was +ve control, group 4 and 5 were treatment groups which received GSO 2% and 4% daily with HCD. The results of this study indicated that the GSO caused an improvement in the blood lipids especially 4% GSO. The 4% GSO decreased serum TC, TG, LDL-c and VLDL significantly (P ˂ 0.05), and caused a significant increase in HDL-C level. Also, 2% GSO decreased TG, LDL-C and VLDL significantly (P ˂ 0.05), whereas the level of HDL-C showed significant increases. Subsequently, GSO enhanced the lipid ratios: atherogenic coefficient (AC), cardiac risk ratio (CRR), LDL-c to HDL-c ratio and atherogenic index of plasma (AIP). Moreover, the serum, liver function (AST, ALT and ALP) levels also, enhanced in the GSO groups. However, 4% GSO led to significant decrease in serum MDA and elevated serum GST. Otherwise, histopathological examination showed enhanced in the heart and aorta of rats compared with the +ve control group. This study indicates that GSO effective in lowering total cholesterol, triglyceride and LDL-c and increasing HDL-c. Therefore, GSO have hypocholesterolemic effect and might be effective to protect against the risk of CVD.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Protective Effect of Grape Seed Oil on Hypercholesterolemia in Rats

Mokhtar¹,

El-Banna²,

Haggag³

2016

IJNFS

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“…Choi et al (2010) showed GSD supplementation in pigs decreased levels of total fat 30% to 20%, this being important note for meat quality and closely correlated with lipid metabolism of animals. Kim et al (2010) studied the effects of GSD on plasma lipid profile in rats and there were also significant reduction in total cholesterol and LDL-cholesterol. Asadi et al (2010) related the GSD intake with the effects on serum cholesterol, hepatic and muscular; they verified in reduction of serum cholesterol in rats after 10 weeks.…”

Section: Gso and Physiological Aspects Of Lipidsmentioning

confidence: 99%

Grape seed oil: a potential functional food?

et al. 2015

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“…The effects of the oil have been studied in rats; it was established that the oil has the ability to reduce total cholesterol and LDL (Kim et al, 2010). Another study notes similar results in the same animal model using grape seed extract.…”

Section: Wwwintechopencommentioning

confidence: 87%