Effect of Greater cardamom (Amomum subulatum Roxb.) on blood lipids, fibrinolysis and total antioxidant status in patients with ischemic heart disease

Verma, Surendra Kumar; Jain, Vartika; Singh, Dharam Raj

doi:10.1016/s2222-1808(12)60255-2

Cited by 30 publications

(44 citation statements)

References 12 publications

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“…In another human study by Verma et al ., on patients with ischaemic heart disease, the intake of greater cardamom ( Amomum subulatum Roxb.) fruit powder for 12 weeks showed an enhancement in the serum total antioxidant status . The conflicting results between the current study and that one may be, again, due to differences in the type of cardamom supplemented ( Elettaria cardamomum vs. greater cardamom ), different durations of intervention, and different target groups.…”

Section: Discussioncontrasting

confidence: 84%

“…A dose of 3.0 g used in the study was chosen based on the two previous human studies investigating the effects of cardamom supplementation . Also, 3.0 g of cardamom powder can be a reasonably large amount to be consumed through a diet.…”

Section: Experimental Statementioning

confidence: 99%

“…Several animal and cellular model studies have shown anti‐inflammatory and anti‐oxidative activities of cardamom . A few human studies have been conducted to investigate the effects of cardamom on inflammation and oxidative stress status, which have shown conflicting results . Supplementation with greater cardamom in patients with ischemic heart disease and Elettaria cardamom in patients with hypertension improved the antioxidant status .…”

Section: Introductionmentioning

confidence: 99%

“…A few human studies have been conducted to investigate the effects of cardamom on inflammation and oxidative stress status, which have shown conflicting results . Supplementation with greater cardamom in patients with ischemic heart disease and Elettaria cardamom in patients with hypertension improved the antioxidant status . However, the results of another study did not show any significant effect of cardamom on blood oxidative stress and inflammation in T2DM patients …”

Section: Introductionmentioning

confidence: 99%

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Cardamom supplementation improves inflammatory and oxidative stress biomarkers in hyperlipidemic, overweight, and obese pre‐diabetic women: a randomized double‐blind clinical trial

et al. 2017

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Section: Discussioncontrasting

confidence: 84%

Section: Experimental Statementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cardamom supplementation improves inflammatory and oxidative stress biomarkers in hyperlipidemic, overweight, and obese pre‐diabetic women: a randomized double‐blind clinical trial

et al. 2017

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“…A total of 40 diabetic patients were calculated in each group (cardamom and placebo groups) based on a significant mean difference of TAC [24], with 95% confidence level, 80% power and additional drop-out rate of 20%.…”

Section: Sample Sizementioning

confidence: 99%

The effects of green cardamom supplementation on blood glucose, lipids profile, oxidative stress, sirtuin-1 and irisin in type 2 diabetic patients: a study protocol for a randomized placebo-controlled clinical trial

Aghasi

Ghazi-Zahedi

Koohdani

et al. 2018

BMC Complement Altern Med

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Prophylactic and therapeutic potential of active phytoconstituents from Amomum subulatum Roxb

et al. 2022

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Amomum subulatum is a popular aromatic and medicinal spice crop being used for centuries to treat a variety of health ailments. The ethnopharmacological use of Amomum subulatum has been described in various medicinal systems including Ayurveda, Unani, and Chinese for its therapeutic properties in mitigating gastrointestinal disorders, lung congestions, respiratory ailments, jaundice, tuberculosis, hyperlipidemia, inflammation, ischemic heart diseases, etc. Literature search using Google Scholar, PubMed, NCBI, Elsevier, Wiley online Library, Springer, Taylor and Francis, Web of Science, Science Direct, Scopus databases was restricted to English-language articles. Significant information on pharmacological properties of Amomum subulatum, including antioxidant (ROS/RNS pathways), anti-inflammatory (TNF-α, IL-1, IL-6, COX-2, NF-кB, HO-1, arachidonic acid pathways), antinephrotoxic (urea, creatinine, Cystatin-C), antihepatotoxic (SGOT, SGPT, and ALP), antidiabetic, etc., was collected for the review. The pharmacological properties of this traditional herb may be attributed to the plethora of secondary metabolites present in it. Preliminary phytochemical screening reported the abundance of flavonoids, terpenoids, steroids, vitamins, minerals, fatty acid esters, etc. 1,8-cineole (60%-80% of total volatile oil), α-terpineol, limonene, α-terpinyl acetate, etc., are the notable phytochemicals reported from Amomum subulatum. However, detailed insights into the molecular mechanistic pathways mediating the beneficial role of this traditional herb on cell/animal models and large-scale clinical trials are lacking.In the present review, we provide a comprehensive description of the current knowledge on Amomum subulatum, including its phytoconstituents, pharmacological uses, and toxicities, its implication in host health effects, including in vitro/in vivo efficacy, and the potential of these emerging species to suggest areas for future research.

show abstract

Effect of Greater cardamom (Amomum subulatum Roxb.) on blood lipids, fibrinolysis and total antioxidant status in patients with ischemic heart disease

Cited by 30 publications

References 12 publications

Cardamom supplementation improves inflammatory and oxidative stress biomarkers in hyperlipidemic, overweight, and obese pre‐diabetic women: a randomized double‐blind clinical trial

Cardamom supplementation improves inflammatory and oxidative stress biomarkers in hyperlipidemic, overweight, and obese pre‐diabetic women: a randomized double‐blind clinical trial

The effects of green cardamom supplementation on blood glucose, lipids profile, oxidative stress, sirtuin-1 and irisin in type 2 diabetic patients: a study protocol for a randomized placebo-controlled clinical trial

Prophylactic and therapeutic potential of active phytoconstituents from Amomum subulatum Roxb

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