Effect of green tea and lycopene on the insulin-like growth factor system: the ProDiet randomized controlled trial

Biernacka, Kalina; Holly, Jeff M.P.; Martin, Richard M.; Frankow, Aleksandra; Bull, Caroline J.; Hamdy, Freddie C.; Donovan, Jenny; Neal, David E.; Metcalfe, Chris; Lane, Athene

doi:10.1097/cej.0000000000000502

Cited by 7 publications

(19 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…read and reviewed the full text of all articles and extracted the following information from each article: year of publication, study design, study location, participant characteristics (sample size, sex, age, body mass index [BMI], and health status), compliance monitoring, intervention characteristics (type and dose of lycopene supplementation, follow‐up period), methods used to measure IGF‐1 and IGFBPs, and means and standard deviations (SDs) of IGF‐1 and IGFBPs at baseline and end of the study, or changes and SDs during the study. Attempts were made to contact the corresponding author when data of a study were insufficient (Biernacka et al, 2019; Gann et al, 2015; Talvas et al, 2010; Voskuil et al, 2008; Vrieling et al, 2007; Walfisch et al, 2007).…”

Section: Methodsmentioning

confidence: 99%

“…However, the study was restricted to adults aged at least 45 years, limiting the generalizability of the results. In addition, this review missed three eligible studies in the analysis (Biernacka et al, 2019; Schwarz et al, 2008; Talvas et al, 2010). Similarly, another meta‐analysis demonstrated no significant associations between lycopene supplementation and IGF‐1 levels (Xie & Yang, 2020); however, some limitations render the results unreliable, including missing three eligible, well‐designed, RCTs (258 participants) (Gann et al, 2015; Talvas et al, 2010; Voskuil et al, 2008), and insufficient explanation on how to calculate the effect size for two articles that did not report enough data for pairwise comparisons (Biernacka et al, 2019; Walfisch et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, this review missed three eligible studies in the analysis (Biernacka et al, 2019; Schwarz et al, 2008; Talvas et al, 2010). Similarly, another meta‐analysis demonstrated no significant associations between lycopene supplementation and IGF‐1 levels (Xie & Yang, 2020); however, some limitations render the results unreliable, including missing three eligible, well‐designed, RCTs (258 participants) (Gann et al, 2015; Talvas et al, 2010; Voskuil et al, 2008), and insufficient explanation on how to calculate the effect size for two articles that did not report enough data for pairwise comparisons (Biernacka et al, 2019; Walfisch et al, 2007). Therefore, in an effort to discern more reliable results, we performed a systematic review of RCTs that investigated the impact of lycopene supplementation on circulating IGF‐1 and IGFBPs concentrations in adults.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effects of lycopene supplementation on insulin‐like growth factor‐1 and insulin‐like growth factor binding proteins: A systematic review of randomized controlled trials

Meshkini

Ramezani‐Jolfaie

Sargazi

et al. 2022

Phytotherapy Research

View full text Add to dashboard Cite

Lycopene has been posited to regulate insulin-like growth factor-1 (IGF-1). We aimed to conduct a systematic review of the effects of lycopene on circulating IGF-1 and insulin-like growth factor binding proteins (IGFBPs) in adults. A systematic search was carried out in PubMed, Scopus, ISI Web of Science, and the Cochrane Library databases for randomized controlled trials (RCTs), published from inception until March 2020. A total of 11 studies fulfilled the selection criteria. Eleven studies examined the effect of lycopene supplementation on IGF-1, one of which reported a significant reduction. Moreover, three, four, and ten studies were found for IGFBP-1, IGFBP-2, and IGFBP-3, respectively; where one study found a significant increase in these proteins. In conclusion, no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBPs levels are evident in the literature. More research is needed to explore the effect of lycopene on IGF-1 system.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effects of lycopene supplementation on insulin‐like growth factor‐1 and insulin‐like growth factor binding proteins: A systematic review of randomized controlled trials

Meshkini

Ramezani‐Jolfaie

Sargazi

et al. 2022

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Normal, physiological prostate cells are less sensitive to lycopene. Thus, they can undergo processes of proliferation and growth stimulated by IGF-1 [ 223 , 224 ]. This was confirmed in the study conducted on a group of patients with diagnosed prostate cancer undergoing surgery.…”

Section: The Role Of Nutritional Factors and Foodstuffs On Prostatmentioning

confidence: 99%

Dietary Factors and Prostate Cancer Development, Progression, and Reduction

et al. 2021

View full text Add to dashboard Cite

Due to the constantly increasing number of cases, prostate cancer has become one of the most important health problems of modern societies. This review presents the current knowledge regarding the role of nutrients and foodstuff consumption in the etiology and development of prostate malignancies, including the potential mechanisms of action. The results of several in vivo and in vitro laboratory experiments as well as those reported by the clinical and epidemiological research studies carried out around the world were analyzed. The outcomes of these studies clearly show the influence of both nutrients and food products on the etiology and prevention of prostate cancer. Consumption of certain nutrients (saturated and trans fatty acids) and food products (e.g., processed meat products) leads to the disruption of prostate hormonal regulation, induction of oxidative stress and inflammation, and alteration of growth factor signaling and lipid metabolism, which all contribute to prostate carcinogenesis. On the other hand, a high consumption of vegetables, fruits, fish, and whole grain products exerts protective and/or therapeutic effects. Special bioactive functions are assigned to compounds such as flavonoids, stilbenes, and lycopene. Since the influence of nutrients and dietary pattern is a modifiable risk factor in the development and prevention of prostate cancer, awareness of the beneficial and harmful effects of individual food ingredients is of great importance in the global strategy against prostate cancer.

show abstract

“…(2015) Lycopene and green tea The Pro-diet randomized controlled trial n = 133, daily Lycopene ( n = 44 assigned 15 mg capsules/day; 44 assigned a Lycopene-rich diet; 45 assigned placebo) and green tea ( n = 45 assigned 600 mg/day epigallocatechin gallate; 45 assigned green tea drink; 43 assigned placebo) for 6 months Serum Lycopene and EGCG level increased with a little reduction in serum IGF-1/2, IGFBP-2/3 level. Biernacka et al. (2019) Lycopene with tomato sauce A randomized placebo-controlled study with a nonrandomized 5th arm study n = 32, daily 30 mg Lycopene containing tomato sauce for 3 weeks before radical prostatectomy.…”

Section: Importance Of Natural Products In Prostate Cancer Therapymentioning

confidence: 99%

Prostate cancer: Therapeutic prospect with herbal medicine

Ghosh

Hazra

Pal

et al. 2021

Current Research in Pharmacology and Drug Discovery

View full text Add to dashboard Cite

Prostate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. A geographic variation on the burden of the disease suggested that the environment, genetic makeup, lifestyle, and food habits modulate one's susceptibility to the disease. Although it has been generally thought to be an older age disease, and awareness and timely execution of screening programs have managed to contain the disease in the older population over the last decades, the incidence is still increasing in the population younger than 50. Existing treatment is efficient for PCa that is localized and responsive to androgen. However, the androgen resistant and metastatic PCa are challenging to treat. Conventional radiation and chemotherapies are associated with severe side effects in addition to being exorbitantly expensive. Many isolated phytochemicals and extracts of plants used in traditional medicine are known for their safety and diverse healing properties, including many with varying levels of anti-PCa activities. Many of the phytochemicals discussed here, as shown by many laboratories, inhibit tumor cell growth and proliferation by interfering with the components in the pathways responsible for the enhanced proliferation, metabolism, angiogenesis, invasion, and metastasis in the prostate cells while upregulating the mechanisms of cell death and cell cycle arrest. Notably, many of these agents simultaneously target multiple cellular pathways. We analyzed the available literature and provided an update on this issue in this review article.

show abstract

Effect of green tea and lycopene on the insulin-like growth factor system: the ProDiet randomized controlled trial

Abstract: Supplemental Digital Content is available in the text.

Cited by 7 publications

References 32 publications

The effects of lycopene supplementation on insulin‐like growth factor‐1 and insulin‐like growth factor binding proteins: A systematic review of randomized controlled trials

The effects of lycopene supplementation on insulin‐like growth factor‐1 and insulin‐like growth factor binding proteins: A systematic review of randomized controlled trials

Dietary Factors and Prostate Cancer Development, Progression, and Reduction

Prostate cancer: Therapeutic prospect with herbal medicine

Contact Info

Product

Resources

About