The Mn-Cu nanoferrites of composition Mn 0.5 Cu 0.5 Fe 2 − 2x Ni x Zr x O 4 (0.00 ≤ x ≤ 0.80) were synthesized by incorporating dopant Zr 4+ and Ni 2+ cations via a chemical coprecipitation technique. The single phase of the prepared spinel nanoferrites with particle sizes 15-31 nm was confirmed by XRD. Both electrical and magnetic properties are found to depend on the x contents and explained by considering the Zr 4+ and Ni 2+ cations distribution, displacement of the Fe 3+ ions by dopants, changes in magnetic moment at tetrahedral A site and octahedral B site, Fe 3+ (A)-O 2 -Fe 3+ [B] linkages and extent of the primary superexchange interactions (A)-O-[B] of the Fe 3+ ions on the A and B-sites. DC resistivity, saturation magnetization (M s ), remanence (M r ) and Bohr magneton (n B ) are observed to increase up to x ≤ 0.40, while these parameters fall at relatively higher value of x ≥ 0.60.