Effect of guarana (<i>Paullinia cupana</i>) on fatigue in breast cancer patients undergoing systemic chemotherapy.

Campos, Maira Paschoin de Oliveira; Riechelmann, Rachel; Martins, L. C.; Hassan, Benjamin Joseph; Casa, Fernanda Branco Assunção; Giglio, A. Del

doi:10.1200/jco.2010.28.15_suppl.9007

Cited by 11 publications

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“…Additionally, there was no severe toxicity and there was no worsening of depression or quality of sleep. The results highlight that guarana is an inexpensive and effective therapeutic alternative for the treatment of fatigue induced by chemotherapy 8 .…”

Section: Introductionmentioning

confidence: 84%

Use of Guarana for Hot Flashes after Breast Cancer: Randomized, Double-Blind, Placebo-Controlled Phase II Trial

Vieira

Mauad

Cubero

et al. 2019

Journal of Natural Remedies

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Background: Hot flashes are common in menopausal women and significantly affect the quality of life of many patients diagnosed with breast cancer for which hormone replacement therapy is not indicated. In a previous uncontrolled study, guarana (Paullinia cupana) showed significant decreases in the amount and intensity of hot flashes in this group of women. Hypothesis/Purpose: The main objective was to reduce the intensity and frequency of hot flashes with the use of PC-18, compared with placebo in women who survived breast cancer without current evidence of disease. Study Design: The present study consists of a double-blind, randomized, placebo-controlled, uni-institutional, two-arm phase II clinical trial. Methods: The experimental group received the purified dry extract of Paullinia cupana (PC-18) at a dose of 37.5 g twice daily, while the other group received placebo, also twice daily. Results: The study included 40 patients who had completed surgical, chemotherapeutic and/or radiotherapeutic treatment for more than 3 months and who were on adjuvant hormone therapy at the time of inclusion, 20 in each arm. Both groups showed significant reductions in the number and intensity of hot flashes, with no significant difference between the arms. There was a higher intensity and frequency of hot flashes in patients receiving tamoxifen compared with those who received aromatase inhibitors. The toxicities observed were not very significant. Conclusion: This concludes that PC-18 did not demonstrate significantly greater capacity than placebo for control of hot flashes in women with a history of breast cancer and adjuvant hormone therapy.

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Section: Introductionmentioning

confidence: 84%

Use of Guarana for Hot Flashes after Breast Cancer: Randomized, Double-Blind, Placebo-Controlled Phase II Trial

Vieira

Mauad

Cubero

et al. 2019

Journal of Natural Remedies

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“…In addition to the stimulating action of CAF on the central nervous system, other effects have been attributed to guarana, such as improved alertness, reaction time, speed of information processing, memory, mood and performance in physical exercises as well as thermogenic effects associated with weight loss and gastric acid secretion. For example, GUA has been shown to be a promising option for the treatment of mental and physical fatigue related to cancer because its use lacks significant side effects and it is low in cost compared with traditional drug therapy (Campos et al, 2011). CAF change neuronal activity as evidenced by fMRI signal changes in a network of brain areas associated with executive and attention functions during running memory processes.…”

Section: Guaranà and Physical Performancementioning

confidence: 99%

Guarana and physical performance: A myth or reality?

D’Angelo¹,

Arillo²

2020

Journal of Human Sport and Exercise - 2020 - Spring Conferences of Sports Science

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Guarana (Paullinia cupana) is a rainforest vine that was domesticated in the Amazon for its caffeine-rich fruits. Each fruit contains from one to three seeds which, properly dried, give rise to a brown paste with a bitter taste. The Food and Drug Administration generally recognizes guarana as safe, although there are no established dosages and it is unclear how much guarana is in each drink, because many companies do not list a milligram amount. The increasing number of energy drink with caffeine-related clearly shows that there seems to be a real risk for adverse health effects such as arrhythmias. However, under moderate use and without combining other stimulants or alcohol, the risk for such side effects seem negligible. Anyway, there is an overwhelming lack of evidence to substantiate claims that guarana contribute to the enhancement of physical or cognitive performance. Additional well-designed, randomized, placebo-controlled studies are needed in order to assess claims made for this product and further elucidate potential adverse effects.

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“…An in vivo study to investigate the association between habitual Guaraná ingestion and the prevalence of metabolic disease exhibited a possible protective effect against obesity, hypertension and metabolic syndrome, all of which are related to a higher risk of cardiovascular disease (Krewer et al, 2011). In another study, the Guaraná extract (50 mg by mouth twice daily) showed antifatigue effects in patients with breast cancer undergoing systemic chemotherapy (Campos et al, 2011).…”

Section: Chemopreventive and Other Activitiesmentioning

confidence: 99%

“…Low toxicity Vermaak (2011), Mello (2010a, , Santa Maria (1998), Mattei (1998), andFonseca (1994) Antioxidant activity Bittencourt (2013), Portella (2013), Dalonso (2012), Majhenic (2007), Mendes and Carlini (2007), Yamaguti-Sasaki (2007), Basile (2005), and Mattei (1998) Antibacterial and antifungal activities Basile (2013Basile ( , 2005, Majhenic (2007), Yamaguti-Sasaki (2007) Antidepressive, anxiolytic and antiamnesic effects Roncon (2011), Shahwar (2010, Antonelli (2007), Majhenic (2007), Otobone (2005Otobone ( , 2007, , Basile (2005), Espinola (1997), and Mattei (1998) Chemoprophylactic in carcinogenesis and antigenotoxic activity Fukumasu (2011Fukumasu ( , 2008Fukumasu ( , 2006a, Oliveira ( , 2011, Leite (2011);Cragg (2006), and Espinola (1997) Inhibition of platelet aggregation Bydlowski (1991Bydlowski ( , 1988) Protection against gastric lesions Campos (2003) Lower risk of obesity, hypertension and metabolic syndrome Krewer (2011) Antifatigue effects Campos (2011) The seeds of Guaraná also contain acylglycerols and cyanolipids (Figure 3), an unusual class of plant lipids restricted to only a few families, such as Sapindaceae, Hippocastanacaeae and Boraginaceae (Moller and Seigler, 1999). The study of the oil from P. cupana Kunth var.…”

Section: Activity Referencementioning

confidence: 99%

Paullinia cupana Kunth (Sapindaceae): A review of its ethnopharmacology, phytochemistry and pharmacology

Hamerski¹,

Somner²,

Tamaio³

2013

J. Med. Plants Res.

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In Western markets, the extract from the seeds of Paullinia cupana Kunth, Sapindaceae, popularly known as Guaraná, is most commonly used in high-energy foods and drinks and dietary supplements. However, a broad spectrum of medicinal activities is reported for P. cupana, ranging from stimulation of the central nervous system, in cases of physical or mental stress, to appetite suppression. It can also be used as an aphrodisiac and a treatment for impotence, as well as a medication to reduce fever, stimulate metabolism, induce antiplatelet, antioxidant and antibacterial activites. In addtition, P. cupana has been used in cosmetic preparations, and it has become a popular soft drink in Brazil. In the last two decades, Guaraná has emerged as a key ingredient in various sports and high-energy drinks. Methylxanthines, including caffeine, cathechins, theophylline and theobromine, and tannins are compounds which are reported for this plant. This article reviews the most up-to-date information on the botanical, chemical and pharmacological aspects of P. cupana extract, as well as its miscellaneous uses.

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Effect of guarana (Paullinia cupana) on fatigue in breast cancer patients undergoing systemic chemotherapy.

Cited by 11 publications

References 0 publications

Use of Guarana for Hot Flashes after Breast Cancer: Randomized, Double-Blind, Placebo-Controlled Phase II Trial

Use of Guarana for Hot Flashes after Breast Cancer: Randomized, Double-Blind, Placebo-Controlled Phase II Trial

Guarana and physical performance: A myth or reality?

Paullinia cupana Kunth (Sapindaceae): A review of its ethnopharmacology, phytochemistry and pharmacology

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