Effect of H1-antagonist Dithiaden® on human PMN-leukocyte aggregation and chemiluminescence is stimulus-dependent

Nosáľ, R; Drábiková, Katarı́na; Čı́ž, Milan; Lojek, Antonı́n; Danihelová, E

doi:10.1007/pl00012427

Cited by 13 publications

(12 citation statements)

References 30 publications

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“…A large proportion of publications on CL are related to cellular CL [110–114]. The scope of cellular CL studies is large and includes investigations of reactive oxygen species produced by human spermatozoa [115], defects in the production of reactive oxygen intermediates [116], responses of cells (e.g., PMN-leukocytes, neutrophils) to drugs [117] and different agents, such as H1-antagonists [118], Fc gamma and complement receptors [119], polyunsaturated fatty acids [120], lectins [121], lysophosphatidic acid [122], Helicobacter pylori lipopolysaccharide [123], and endotoxins [124]. A noninvasive luminol bioluminescence imaging method was developed to distinguish chronic and acute inflammation in animal models.…”

Section: Cellular Chemiluminescensementioning

confidence: 99%

Luminol-Based Chemiluminescent Signals: Clinical and Non-clinical Application and Future Uses

Khan

Idrees

Moxley

et al. 2014

Appl Biochem Biotechnol

238

181

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Chemiluminescence (CL) is an important method for quantification and analysis of various macromolecules. A wide range of CL agents such as luminol, hydrogen peroxide, fluorescein, dioxetanes and derivatives of oxalate, and acridinium dyes are used according to their biological specificity and utility. This review describes the application of luminol chemiluminescence (LCL) in forensic, biomedical, and clinical sciences. LCL is a very useful detection method due to its selectivity, simplicity, low cost, and high sensitivity. LCL has a dynamic range of applications, including quantification and detection of macro and micromolecules such as proteins, carbohydrates, DNA, and RNA. Luminol-based methods are used in environmental monitoring as biosensors, in the pharmaceutical industry for cellular localization and as biological tracers, and in reporter gene-based assays and several other immunoassays. Here, we also provide information about different compounds that may enhance or inhibit the LCL along with the effect of pH and concentration on LCL. This review covers most of the significant information related to the applications of luminol in different fields.

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Section: Cellular Chemiluminescensementioning

confidence: 99%

Luminol-Based Chemiluminescent Signals: Clinical and Non-clinical Application and Future Uses

Khan

Idrees

Moxley

et al. 2014

Appl Biochem Biotechnol

238

181

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“…Inhibition of platelet functions might consist of several types of drug-cell interactions, depend on the structure and physico-chemical properties of the drugs and cannot be estimated simply on the basis of partition coefficients [139]. Dose-dependent inhibition of aggregation due to DIT and BRO was followed by the inhibition of AA liberation from membrane phospholipids of platelets stimulated either at the receptor site (thrombin) or by a stimulus bypassing membrane receptors (Ca 2+ ionophore A23187) [140].…”

Section: Ah -Platelet Adhesion and Aggregationmentioning

confidence: 99%

“…In stimulated platelets BRO, first, inhibits the AA pathway, second, acts inside the platelets since the stimulatory effect of A23187 does not depend on surface receptors and third, attacks process(es) involved in the action of both thrombin and A23187. Antihistaminic drugs interfere with stimulated aggregation by inhibiting PLA 2 rather than the intraplatelet Hi [133,[138][139][140].…”

Section: Ah and Arachidonate Pathway In Plateletsmentioning

confidence: 99%

Antiplatelet and Antileukocyte Effects of Cardiovascular,Immunomodulatory and Chemotherapeutic Drugs

Nosáľ¹

2006

CHAMC

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In vitro and ex vivo interactions of betaadrenoceptor blocking drugs, antihistamines and chloroquine with blood platelets and polymorphonuclear leukocytes resulted in different alterations of regulatory functions of these blood cells. Inhibition of platelet aggregation, arachidonate regulatory pathway, 5-hydroxytryptamine transportation, removal of platelet membrane receptors, inhibition of second messenger pathways at subcellular level and suppression of phagocytosis are indicative of nonreceptor rather than specific receptor interactions. Binding of drugs with biomembranes is reversible depending on the ionic charge of the molecule and hydrophobicity of the bilayer, partition coefficient, pH and pKa of the amphiphilic molecules and other physico-chemical properties of amphiphilic drugs. Alterations in the drug molecule structure alters the drug-phospholipid binding profile. Any change in the metabolism of membrane phospholipids directly or indirectly influences one or more of the important components of the phospholipid-signalling pathway. In addition to changes in phospholipase A, C and D activities, protein kinase C, calmodulin-phosphodiesterase, Ca2+,Mg2+-ATPase, Na+,K+-ATPase and other messengers were found to be changed in cells and tissue after cationic amphiphilic drug (CAD) administration. Although not much has been understood of the mechanism by which some CAD affect immune functions, there are good reasons to suggest that these effects might occur. CADs share sufficient similarities in their structure even though they come from diverse pharmacological classes. CADs affect ion transport, immune functions, tumour growth, serotonin metabolism and several other functions in the body. Extensive therapeutic use and associated side effects have generated a great deal of interest in understanding the nonreceptor interactions with CADs.

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“…This function is performed by leukocytes, mainly neutrophils. As observed [1,2], the histamine H 1 -antagonist dithiaden inhibits production of reactive oxygen species (ROS) by phagocytes. Our aim was to compare the inhibitory effects of dithiaden with those of four second-generation H 1 -antihistamines -loratadine, acrivastine, astemizole and ketotifen-fumarate.…”

Section: Introductionmentioning

confidence: 99%

Effect of H1-antihistamines on the oxidative burst of rat phagocytes

et al. 2006

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Effect of H1-antagonist Dithiaden® on human PMN-leukocyte aggregation and chemiluminescence is stimulus-dependent

Cited by 13 publications

References 30 publications

Luminol-Based Chemiluminescent Signals: Clinical and Non-clinical Application and Future Uses

Luminol-Based Chemiluminescent Signals: Clinical and Non-clinical Application and Future Uses

Antiplatelet and Antileukocyte Effects of Cardiovascular,Immunomodulatory and Chemotherapeutic Drugs

Effect of H1-antihistamines on the oxidative burst of rat phagocytes

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