Effect of habitual exercise on urinary liver‐type fatty acid‐binding protein levels in middle‐aged and older adults

Kosaki, Keisei; Kamijo‐Ikemori, Atsuko; Sugaya, Takeshi; Tanahashi, Koichiro; Sawano, Yuriko; Akazawa, Nobuhiko; Ra, Song‐Gyu; Kimura, Kenjiro; Shibagaki, Yugo; Maeda, Seiji

doi:10.1111/sms.12867

Cited by 12 publications

(16 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the reduction in renal blood flow by the high‐intensity exercise is likely to be transient, the kidney is vulnerable to hypoperfusion and hypoxia, and therefore, may be affected by renal hypoxia due to the high‐intensity exercise. While there are previous studies shown the continuous moderate‐intensity exercise may have a beneficial effect on the kidney, the influence of high‐intensity exercise on the renal conditions are still not fully characterized.…”

Section: Introductionmentioning

confidence: 99%

Incremental short maximal exercise increases urinary liver‐type fatty acid‐binding protein in adults without CKD

Kosaki

Kamijo‐Ikemori

Sugaya

et al. 2020

Scandinavian Med Sci Sports

Self Cite

View full text Add to dashboard Cite

Exercise‐induced redistribution of tissue blood flow decreases the renal blood flow in an exercise intensity‐dependent manner. However, the acute effects of incremental short maximal exercise on renal tubular conditions remain unknown. The purpose of this study was to investigate the acute effects of incremental short maximal exercise on the urinary liver‐type fatty acid‐binding protein, which is a highly sensitive tubular biomarker that correlates excellently with peritubular capillary blood flow. A total of 116 adults (aged 24‐83 years) without chronic kidney disease performed the incremental short maximal exercise using a cycling ergometer, wherein the exercise sequence consisted of commencing with a 2‐min workout period at 20 W (as a warm‐up period) and then followed by a 10‐20 W increase every 1 minute until termination criteria were reached. Urinary samples were gathered before and immediately after the exercise to evaluate the concentrations of urinary creatinine, albumin, and liver‐type fatty acid‐binding protein. Urinary excretion levels of albumin and liver‐type fatty acid‐binding protein were significantly increased post‐exercise (P < .001 and P = .008, respectively). Furthermore, the % change in urinary liver‐type fatty acid‐binding protein levels after exercise was found to correlate independently with age, estimated glomerular filtration rate at baseline, and the % change in urinary albumin (Model R2 = 0.451, P < .001). Our findings suggest that incremental short maximal exercise may lead to acute slightly adverse effects on tubular conditions, especially in young adults or adults with lower renal function, even without chronic kidney disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Incremental short maximal exercise increases urinary liver‐type fatty acid‐binding protein in adults without CKD

Kosaki

Kamijo‐Ikemori

Sugaya

et al. 2020

Scandinavian Med Sci Sports

Self Cite

View full text Add to dashboard Cite

show abstract

“…There is also some evidence from literature about the role of PA on other interesting markers like CAF and urinary L-FABP [40], but further studies should be designed to confirm and fully explain these results.…”

Section: Discussionmentioning

confidence: 97%

“…Moreover, a recent paper investigated the possible role of PA on renal proximal tubule stress levels through the evaluation of urinary levels of liver-type fatty acid-binding protein (L-FABP). The intent of the study was two-fold: in a cross-sectional evaluation, urinary L-FABP levels were significantly lower in those subjects with higher PA levels than in those with lower PA levels; in the interventional study, those subjects that underwent 12 weeks of aerobic training had significantly decreased levels of urinary L-FABP [40].…”

Section: Effect Of Pa On Other Biohumoral Markersmentioning

confidence: 99%

Biohumoral Indicators Influenced by Physical Activity in the Elderly

Fossati

Torre

Borrione

et al. 2020

JCM

View full text Add to dashboard Cite

In the scientific landscape, there is a growing interest in defining the role of several biomolecules and humoral indicators of the aging process and in the modifications of these biomarkers induced by physical activity and exercise. The main aim of the present narrative review is to collect the available evidence on the biohumoral indicators that could be modified by physical activity (PA) in the elderly. Online databases including Pubmed, Web of science (Medline), and Scopus were searched for relevant articles published in the last five years in English. Keywords and combination of these used for the search were the following: “biological”, “indicators”, “markers”, “physical”, “activity”, and “elderly”. Thirty-four papers were analyzed for inclusion. Twenty-nine studies were included and divided into four categories: cardiovascular (CV) biomarkers, metabolic biomarkers, inflammatory markers-oxidative stress molecules, and other markers. There are many distinct biomarkers influenced by PA in the elderly, with promising results concerning the metabolic and CV indexes, as a growing number of studies demonstrate the role of PA on improving parameters related to heart function and CV risk like atherogenic lipid profile. Furthermore, it is also a verified hypothesis that PA is able to modify the inflammatory status of the subject by decreasing the levels of pro-inflammatory cytokines, including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). PA seems also to be able to have a direct effect on the immune system. There is a strong evidence of a positive effect of PA on the health of elderly people that could be evidenced and “quantified” by the modifications of the levels of several biohumoral indicators.

show abstract

“…The results of the present study indicated a correlation between urinary markers and sarcopenia in mature rats with T2D and DKD. Our previous studies found that lower physical activity or weaker muscle strength was related to increased urinary L-FABP levels, but not urinary albumin [10], and that intervention with aerobic exercise training facilitated a reduction in increased urinary L-FABP in healthy middle-aged and older adults [11]. Furthermore, decreased muscle strength was independently associated with increased intrarenal vascular resistance [19], suggesting that sarcopenia might lead to impairments to the intrarenal vasculature.…”

Section: Discussionmentioning

confidence: 98%

“…Urinary liver-type fatty acid-binding protein (L-FABP) accurately reflects the degree of tubulointerstitial damage [7,8] and has been accepted as a tubular marker by the Ministry of Health, Labour and Welfare in Japan [9]. Moreover, a study by our group found that urinary L-FABP levels were inversely associated with exercise capacity or physical activity and that aerobic exercise training decreased urinary L-FABP levels in healthy middle-aged and older adults [10,11]. Therefore, urinary L-FABP may be useful to monitor the progression of sarcopenia.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats

Tanabe

Ogura

Kosaki

et al. 2020

Journal of Diabetes Research

View full text Add to dashboard Cite

Background. Type 2 diabetes (T2D) is a known risk factor for diabetic kidney disease (DKD) and sarcopenia in older patients. Because there may be an interaction between DKD and sarcopenia, the aim of the present study is to investigate the relationship between urinary levels of liver-type fatty acid-binding protein (L-FABP) and sarcopenia using a novel rat model of T2D. Methods. Male spontaneously diabetic Torii (SDT) fatty rats (n=5) at 16 weeks of age were used as an animal model of T2D. Age- and sex-matched Sprague-Dawley (SD) rats (n=7) were used as controls. Urine samples were obtained from the rats, and muscle strength was evaluated with the use of the forelimb grip test at 16, 20, and 24 weeks of age. Serum, kidney, soleus, and extensor digitorum longus (EDL) muscle samples were collected at 24 weeks of age. Urinary L-FABP levels were measured using dedicated enzyme-linked immunosorbent assays. Results. Increased urinary L-FABP levels, focal glomerular sclerosis, moderate interstitial inflammation and fibrosis, and accumulation of renal oxidative proteins were significantly observed in the SDT fatty rats, compared to the SD rats. Muscle weight, muscle strength, cross-sectional areas of both type I and type IIb muscle fibers, and increasing rate of muscle strength were significantly decreased in the SDT fatty rats compared to the SD rats at 24 weeks. Urinary L-FABP levels at 20 and 24 weeks were significantly negatively correlated with muscle strength. Urinary L-FABP levels at 16 weeks were significantly negatively correlated with the increasing rate of muscle strength. Conclusions. Urinary L-FABP reflects the degree of muscle strength and weight, as well as cross-sectional areas of muscle fibers. Although further clinical study is needed, urinary L-FABP may be useful to monitor the progression of sarcopenia and DKD in T2D patients.

show abstract

Effect of habitual exercise on urinary liver‐type fatty acid‐binding protein levels in middle‐aged and older adults

Cited by 12 publications

References 38 publications

Incremental short maximal exercise increases urinary liver‐type fatty acid‐binding protein in adults without CKD

Incremental short maximal exercise increases urinary liver‐type fatty acid‐binding protein in adults without CKD

Biohumoral Indicators Influenced by Physical Activity in the Elderly

Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats

Contact Info

Product

Resources

About