Effect of Haemophilus Pertussis Vaccine on Human Beings

Mathov, E

doi:10.1111/j.1398-9995.1962.tb02975.x

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…In three controlled studies in children, histamine sensitization could not be demonstrated in association with B. pertussis infection or following vaccination (269,501,618). In the most recent study, Gifford et al compared skin test sensitivity to histamine in DT-and DTP-immunized children and found no significant difference in wheal size between the two groups (269).…”

Section: Virulence Determinantsmentioning

confidence: 99%

“…To summarize, histamine sensitization in mice in response to B. pertussis infection was first described over 50 years ago (606). Subsequently, histamine sensitization was studied by many investigators, but only five studies involving humans were carried out (269,486,501,561,574,576,618,622,625,686,701,801). In a 1948 study, Parfentjev and Goodline found that mice injected intraperitoneally with a pertussis vaccine subsequently became hypersensitive to histamine challenge; 2 mg of histamine had similar lethality in sensitized (previously vaccinated) mice as did 50 mg in unvaccinated mice (606).…”

Section: Virulence Determinantsmentioning

confidence: 99%

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Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

2005

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Bordetella respiratory infections are common in people (B. pertussis) and in animals (B. bronchiseptica). During the last two decades, much has been learned about the virulence determinants, pathogenesis, and immunity of Bordetella. Clinically, the full spectrum of disease due to B. pertussis infection is now understood, and infections in adolescents and adults are recognized as the reservoir for cyclic outbreaks of disease. DTaP vaccines, which are less reactogenic than DTP vaccines, are now in general use in many developed countries, and it is expected that the expansion of their use to adolescents and adults will have a significant impact on reducing pertussis and perhaps decrease the circulation of B. pertussis. Future studies should seek to determine the cause of the unique cough which is associated with Bordetella respiratory infections. It is also hoped that data gathered from molecular Bordetella research will lead to a new generation of DTaP vaccines which provide greater efficacy than is provided by today's vaccines

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Section: Virulence Determinantsmentioning

confidence: 99%