Effect of haloperidol on a Symbol Digit Substitution Task in normal adult males

Magliozzi, Joseph R.; Mungas, Dan M; Laubly, Justine N.; Blunden, Dale

doi:10.1016/0893-133x(89)90004-3

Cited by 19 publications

(9 citation statements)

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“…Eighteen studies were solely devoted to haloperidol, and 12 studies used haloperidol as a reference for other neuroleptics. On average, there were 17 healthy participants (range 5–110) per study [2, 19, 47, 48, 52, 53, 55–107].…”

Section: Resultsmentioning

confidence: 99%

Biomarkers for the effects of antipsychotic drugs in healthy volunteers

Visser

Post

Pieters

et al. 2001

Brit J Clinical Pharma

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Studies of novel antipsychotics in healthy volunteers are traditionally concerned with kinetics and tolerability, but useful information may also be obtained from biomarkers of clinical endpoints. A useful biomarker should meet the following requirements: a consistent response across studies and antipsychotics; a clear response of the biomarker to a therapeutic dose; a dose±response relationship; a plausible relationship between biomarker, pharmacology and pathogenesis. In the current review, all individual tests found in studies of neuroleptics in healthy volunteers since 1966 were progressively evaluated for compliance with these requirements. A MedLine search yielded 65 different studies, investigating the effects of 23 different neuroleptics on 101 different (variants of ) neuropsychological tests, which could be clustered into seven neuropsychological domains. Subjective and objective measures of alertness, and of visual-visuomotor-auditory and motor skills were most sensitive to antipsychotics, although over half of all the studies failed to show statistically signi®cant differences from placebo. The most consistent effects were observed using prolactin response and saccadic eye movements, where 96% and 83% of all studies resp. showed statistically signi®cant effects. The prolactin inducing dose equivalencies relative to haloperidol of 19 different antipsychotic agents correlated with the lowest recommended daily maintenance dose (r 2 =0.52). This relationship could re¯ect the clinical practice of aiming for maximum tolerated levels, or it could represent a common basis behind prolactin release and antipsychotic activity (probably D 2 -receptor antagonism). The number of tests used in human psychopharmacology appears to be excessive. Future studies should look for the most speci®c and sensitive test within each of the domains that are most susceptible to neuroleptics.

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Section: Resultsmentioning

confidence: 99%

Biomarkers for the effects of antipsychotic drugs in healthy volunteers

Visser

Post

Pieters

et al. 2001

Brit J Clinical Pharma

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“…Impairments of the DSST by phenothiazines were Þrst reported in 1957 (Kornetsky et al 1957) and are relatively well established. An early study suggested that DSST performance was improved by haloperidol (James and James 1973), but more recent studies point to a deterioration in performance (Magliozzi et al 1989;. The CAT has been developed more recently (Tiplady 1988) and is sensitive to a range of compounds including chlorpromazine (Tiplady 1992).…”

Section: Discussionmentioning

confidence: 98%

The effects of haloperidol on visual search, eye movements and psychomotor performance

et al. 1997

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The effects of single doses of haloperidol (2, 4 and 6 mg) were compared with lorazepam 2.5 mg and placebo in 15 healthy subjects. Visual search strategy was measured, along with a range of psychomotor and eye movement tests. Patients with Parkinson's disease have been shown to exhibit a shift from parallel to serial processing in visual search, but we demonstrated that this does not occur following administration of either haloperidol or lorazepam. Haloperidol was detected by visual analogue rating scales and peak saccadic velocity, the latter being the more sensitive measure. Haloperidol had no statistically significant effect on smooth pursuit position error, velocity error or saccadic intrusions. Digit symbol substitution performance was clearly diminished by haloperidol, but there was no effect on the continuous attention test. Lorazepam decreased performance in all tests apart from saccadic latency.

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“…In case of patients with bipolar disorder we cannot exclude the effect of treatment with lithium on TSH level. Lithium may cause hypothyroidism, it was also reported that anti-depressants [28] as well as haloperidol [29] may affect thyroid functions and we have no detailed data on treatment that could be included in the analysis. On the other hand, the large sample size and ability to compare three major clinical groups (schizophrenia, unipolar depression and bipolar disorder) are strengths of the study.…”

Section: Discussionmentioning

confidence: 99%

Level of Thyroid-Stimulating Hormone (TSH) in Patients with Acute Schizophrenia, Unipolar Depression or Bipolar Disorder

Wysokiński

Kłoszewska

2014

Neurochem Res

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The aim of this study is to investigate differences in thyroid-stimulating hormone (TSH) level in patients with acute schizophrenia, unipolar depression, bipolar depression and bipolar mania. Serum level of TSH was measured in 1,685 Caucasian patients (1,064 women, 63.1 %; mean age 46.4). Mean serum TSH concentration was: schizophrenia (n = 769) 1.71 μIU/mL, unipolar depression (n = 651) 1.63 μIU/mL, bipolar disorder (n = 264) 1.86 μIU/mL, bipolar depression (n = 203) 2.00 μIU/mL, bipolar mania (n = 61) 1.38 μIU/mL (H = 11.58, p = 0.009). Depending on the normal range used, the overall rate of being above or below the normal range was 7.9–22.3 % for schizophrenia, 13.9–26.0 % for unipolar depression, 10.8–27.6 % for bipolar disorder, 12.2–28.5 % for bipolar depression, and 11.4–24.5 % for bipolar mania. We have also found differences in TSH levels between the age groups (≤20, >20 years and ≤40, >40 years and ≤60 years and >60 years). TSH level was negatively correlated with age (r = − 0.23, p < 0.001). Weak correlations with age have been found in the schizophrenia (r = − 0.21, p < 0.001), unipolar depression (r = − 0.23, p < 0.001), bipolar depression (r = − 0.25, p = 0.002) and bipolar disorder (r = − 0.21, p = 0.005) groups. Our results confirm that there may be a higher prevalence of thyroid dysfunctions in patients with mood disorders (both unipolar and bipolar) and that these two diagnostic groups differ in terms of direction and frequency of thyroid dysfunctions.

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Effect of haloperidol on a Symbol Digit Substitution Task in normal adult males

Cited by 19 publications

References 0 publications

Biomarkers for the effects of antipsychotic drugs in healthy volunteers

Biomarkers for the effects of antipsychotic drugs in healthy volunteers

The effects of haloperidol on visual search, eye movements and psychomotor performance

Level of Thyroid-Stimulating Hormone (TSH) in Patients with Acute Schizophrenia, Unipolar Depression or Bipolar Disorder

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