Effect of Hawthorn (Crataegus aronia syn. Azarolus (L)) on Platelet Function in Albino Wistar Rats

Shatoor, Abdullah S.; Soliman, Hesham S. M.; Al‐Hashem, Fahaid; Gamal, Basiouny El; Othman, Adel; El-Menshawy, Nadia

doi:10.1016/j.thromres.2012.01.001

Cited by 41 publications

(22 citation statements)

References 49 publications

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“…Crataegus aronia extract was prepared as previously reported by our group (Al Humayed 2016;Shatoor et al, 2012).…”

Section: Methodsmentioning

confidence: 99%

“…The hawthorn plant (Crataegus species) is widely used worldwide in herbal medicine to treat a broad range of diseases such as heart diseases (Tassell et al, 2010), atherosclerosis (Quettier-Deleu et al, 2003), and antiplatelet function (Shatoor et al, 2012). We recently reported protective and therapeutic effects of Crataegus aronia extracts on NAFLD in animal models (Al Humayed 2016), and here we investigated the ultrastructural changes in hepatocytes upon induction of hepatic steatosis in rats fed on a high fat diet using transmission electron microscopy (TEM) and compared the effects of Crataegus aronia and simvastatin on restoring the architecture of liver cells distorted by the disease.…”

Section: Introductionmentioning

confidence: 99%

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Differential Therapeutic Effects of Crataegus aronia and Simvastatin on the Hepatocyte Ultrastructure in Hepatic Steatosis

et al. 2017

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SUMMARY:Complications of fat accumulation in liver, hepatic steatosis such as liver cirrhosis and liver failure are among the common public health problems. We sought to investigate the damage to the hepatocyte ultrastructure induced by high fat diets (HFD) and compared the therapeutic effects at the cellular level of two antioxidant and lipid lowering agents; Crataegus aronia extracts and simvastatin on hepatic steatosis. Rats were either fed with HFD (model group) or low fat diets (LFD) (control group) for 15 weeks before being sacrificed and therapeutic groups started the treatment with these agents after week 11 until the sacrifice day. Harvested liver tissues were examined using transmission electron microscopy (TEM) and liver homogenates were assayed for markers of antioxidative stress that are known to be modulated in liver injury. TEM examinations of the model group showed a profound damage to the hepatocytes compared to the control group as demonstrated by steatosis, damaged mitochondria and vaculated cytoplasm, disrupted rough and smooth endoplasmic reticulum and nuclear membrane, dilated intercellular space between hepatocytes, and alterations in lysosomes. In addition, HFD ameliorated the anti-oxidant glutathione (GSH) and augmented the oxidative stress TBARS biomarkers. Both Crataegus aronia and simvastatin significantly reduced lipids and TBARS, and treated damage to hepatic cells, but hepatocyte structures were differentially responded to these agents. However, only Crataegus aronia induced GSH (p=0.001). We conclude that HFD-induced hepatic steatosis caused a substantial damage to the hepatocyte's ultrastructures, and Crataegus aronia and simvastatin treatments differentially reversed hepatic injuries.

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“…Crataegus aronia extract was prepared as previously reported by our group (Al Humayed 2016;Shatoor et al, 2012).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differential Therapeutic Effects of Crataegus aronia and Simvastatin on the Hepatocyte Ultrastructure in Hepatic Steatosis

et al. 2017

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“…Crataegus extract had effective antiplatelet activity at low doses of 100, 200, and 500 mg/kg as indicated by the increase in bleeding time, decrease in platelet aggregation as assessed by PFA-100, and reduction in serum levels of thromboxane B2 [45]. …”

Section: Cardiovascular Effectmentioning

confidence: 99%

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Wang

Xiong

Feng

2013

Evidence-Based Complementary and Alternative Medicine

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Hawthorn (Crataegus oxyacantha) is a widely used Chinese herb for treatment of gastrointestinal ailments and heart problems and consumed as food. In North America, the role of treatment for heart problems dates back to 1800. Currently, evidence is accumulating from various in vivo and in vitro studies that hawthorn extracts exert a wide range of cardiovascular pharmacological properties, including antioxidant activity, positive inotropic effect, anti-inflammatory effect, anticardiac remodeling effect, antiplatelet aggregation effect, vasodilating effect, endothelial protective effect, reduction of smooth muscle cell migration and proliferation, protective effect against ischemia/reperfusion injury, antiarrhythmic effect, lipid-lowering effect and decrease of arterial blood pressure effect. On the other hand, reviews of placebo-controlled trials have reported both subjective and objective improvement in patients with mild forms of heart failure (NYHA I–III), hypertension, and hyperlipidemia. This paper discussed the underlying pharmacology mechanisms in potential cardioprotective effects and elucidated the clinical applications of Crataegus and its various extracts.

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“…The extract was prepared according to the Cai et al [14]. Rats were orally received a single dose (500 mg/kg of body weight or 10 mL/kg of body weight) of liquid extraction of Sorkh valik at the end of daily exercise training session [15]. The saline groups were treated with the same volume of saline solution.…”

Section: Methodsmentioning

confidence: 99%

Heart ATP-Binding Cassette protein A1 and G1, Peroxisome Proliferator-Activated Receptor-α and Liver X Receptors Genes Expression in Response to Intensive Treadmill Running and Red Crataegus pentaegyna (Sorkh valik) in Male Rats

Ghanbari–Niaki

Abarghooi

Gholizadeh

2015

Zahedan J Res Med Sci

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Background:The heart has a very high energy demand and to sustain sufficient ATP generation, can use a variety of different carbon substrates as energy sources if available. Objectives:The purpose of the current study was to investigate the effect of a high intensity treadmill running training (8 weeks) with or without aqueous extraction of Crataegus pentaegyna (Sorkh valik) on heart ABCA1, ABCG1, PPARα and LXR genes expression. Materials and Methods:In this experimental study, 20 Wistar male rats (4-6 weeks old, 158.9 ± 9.59 g weight) were used. Animals were randomly assigned into saline-control (SC, n = 5), saline-training (ST, n = 5), Sorkh valik-control (SVC, n = 5) and Sorkh valik-training (SVT, n = 5) groups. Training groups have performed a high intensity running program 34 m/min on a motor-driven treadmill for 8 weeks. Animals were fed orally with Sorkh valik extraction (500 mg/kg) and saline solution for last 6 weeks. Seventy two hours after the last training session, rats were sacrificed, heart were excised, cleaned and immediately frozen in liquid nitrogen and stored at -70°C until RNA extraction. Statistical analysis was performed using a two way ANOVA, and significance was accepted at P < 0.05. Results: Changes in ABCA1 and ABCG1 gene expression were not significant and a non-significant increase in PPAR-α and LXR genes expression were found in the trained rats and Sorkh valik-control group than in the control group. Conclusions: The findings indicate that training and Sorkh valik extraction solely were able to increase non-significantly all selected genes expression in rat heart. It seems that exercise with Sorkh valik supplementation trend to decrease mentioned genes expression.

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Effect of Hawthorn (Crataegus aronia syn. Azarolus (L)) on Platelet Function in Albino Wistar Rats

Cited by 41 publications

References 49 publications

Differential Therapeutic Effects of Crataegus aronia and Simvastatin on the Hepatocyte Ultrastructure in Hepatic Steatosis

Differential Therapeutic Effects of Crataegus aronia and Simvastatin on the Hepatocyte Ultrastructure in Hepatic Steatosis

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Heart ATP-Binding Cassette protein A1 and G1, Peroxisome Proliferator-Activated Receptor-α and Liver X Receptors Genes Expression in Response to Intensive Treadmill Running and Red Crataegus pentaegyna (Sorkh valik) in Male Rats

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