The Study aim to determinants of metabolic syndrome. Metabolic Syndrome (MetS) is a complex metabolic disorder caused by obesity, insulin resistance, diabetes mellitus, and hypertension. Aim this study is determinants of metabolic syndrome. This is a cross-sectional study, with a number of samples consisting of 192 respondents. The sample collection technique was a non-probability sampling technique with purposive sampling. The sample used in this study were outpatients at the Health Center in Ternate City, who met the following criteria: outpatients with hypertension and type 2 diabetes mellitus, had metabolic syndrome, and underwent examination blood sugar and fat profile laboratory. Data analysis using the Chi-square test and multiple logistic regression. The results obtained were that there was a significant relationship between metabolic syndrome with the length of time suffering from ρ value 0.000 <α (0.05), family history of disease ρ value 0.019 <α (0.05), physical activity ρ value 0.000 <α (0.05), dietary pattern ρ value 0.001 <α (0.05) and age ρ value 0.000 <α (0.05). There was no significant relationship between metabolic syndrome and smoking status ρ value 0.309> α (0.05).