Effect of heat stress on endotoxin flux across mesenteric-drained and portal-drained viscera of dairy goat

Wang, L.; Xue, Bine; Wang, K.; Li, S.; Li, Z.

doi:10.1111/j.1439-0396.2010.01074.x

Cited by 15 publications

(15 citation statements)

References 19 publications

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“…Systemically, changes in intestinal integrity were accompanied by an increase in circulating endotoxin. Increased circulating endotoxin during HS has been reported in several previous studies (Hall et al, 2001a;Lambert, 2008;Wang et al, 2011;Pearce et al, 2013b) and our current results fit with previous data. Interestingly, we also observed a decrease in circulating LBP.…”

Section: Discussionsupporting

confidence: 83%

Short-term exposure to heat stress attenuates appetite and intestinal integrity in growing pigs1

Pearce

Fernández

Hollis

et al. 2014

Journal of Animal Science

148

111

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Acute heat stress (HS) and heat stroke can be detrimental to the health, well-being, and performance of mammals such as swine. Therefore, our objective was to chronologically characterize how a growing pig perceives and initially copes with a severe heat load. Crossbred gilts (n=32; 63.8±2.9 kg) were subjected to HS conditions (37°C and 40% humidity) with ad libitum intake for 0, 2, 4, or 6 h (n=8/time point). Rectal temperature (Tr), respiration rates (RR), and feed intake were determined every 2 h. Pigs were euthanized at each time point and fresh ileum and colon samples were mounted into modified Ussing chambers to assess ex vivo intestinal integrity and function. Transepithelial electrical resistance (TER) and fluorescein isothiocyanate-labeled dextran (FD4) permeability were assessed. As expected, Tr increased linearly over time (P<0.001) with the highest temperature observed at 6 h of HS. Compared to the 0-h thermal-neutral (TN) pigs, RR increased (230%; P<0.001) in the first 2 h and remained elevated over the 6 h of HS (P<0.05). Feed intake was dramatically reduced due to HS and this corresponded with significant changes in plasma glucose, ghrelin, and glucose-dependent insulinotropic peptide (P<0.050). At as early as 2 h of HS, ileum TER linearly decreased (P<0.01), while FD4 linearly increased with time (P<0.05). Colon TER and FD4 changed due to HS in quadratic responses over time (P=0.050) similar to the ileum but were less pronounced. In response to HS, ileum and colon heat shock protein (HSP) 70 mRNA and protein abundance increased linearly over time (P<0.050). Altogether, these data indicated that a short duration of HS (2-6 h) compromised feed intake and intestinal integrity in growing pigs. KeywordsAnimal Science, appetite, heat stress, intestinal integrity, swine ABSTRACT: Acute heat stress (HS) and heat stroke can be detrimental to the health, well-being, and performance of mammals such as swine. Therefore, our objective was to chronologically characterize how a growing pig perceives and initially copes with a severe heat load. Crossbred gilts (n = 32; 63.8 ± 2.9 kg) were subjected to HS conditions (37°C and 40% humidity) with ad libitum intake for 0, 2, 4, or 6 h (n = 8/time point). Rectal temperature (T r ), respiration rates (RR), and feed intake were determined every 2 h. Pigs were euthanized at each time point and fresh ileum and colon samples were mounted into modified Ussing chambers to assess ex vivo intestinal integrity and function. Transepithelial electrical resistance (TER) and fluorescein isothiocyanate-labeled dextran (FD4) permeability were assessed. As expected, T r increased linearly over time (P < 0.001) with the highest temperature observed at 6 h of HS. Compared to the 0-h thermal-neutral (TN) pigs, RR increased (230%; P < 0.001) in the first 2 h and remained elevated over the 6 h of HS (P < 0.05). Feed intake was dramatically reduced due to HS and this corresponded with significant changes in plasma glucose, ghrelin, and glucose-dependent insulinotropic peptide (P < ...

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Section: Discussionsupporting

confidence: 83%

Short-term exposure to heat stress attenuates appetite and intestinal integrity in growing pigs1

Pearce

Fernández

Hollis

et al. 2014

Journal of Animal Science

148

111

View full text Add to dashboard Cite

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“…Heat stress induces oxidative stress that stimulates certain body defense mechanisms and increase oxidative stress-related biomarkers such as SOD in order to scavenge free radicals [59]. Various studies claimed that heat stress increases the blood SOD in cows [60], goats [61], and mice [62], which is similar to our findings.…”

Section: Discussionsupporting

confidence: 90%

Association Analysis of Polymorphisms in the 5′ Flanking Region of the HSP70 Gene with Blood Biochemical Parameters of Lactating Holstein Cows under Heat and Cold Stress

Abbas

Fang

et al. 2020

Animals

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Thermal stress (heat and cold) has large economic and welfare implications for the worldwide dairy industry. Therefore, it is paramount to understand the genetic background of coping mechanism related to thermal stress for the implementation of effective genetic selection schemes in dairy cattle. We performed an association study between 11 single nucleotide polymorphisms having minor allelic frequency (MAF > 0.05) in the HSP70 gene with blood biochemical parameters. The concentrations of growth hormone (GH), lactate (LA), prolactin (PRL), and superoxide dismutase (SOD) in blood were significantly higher (p < 0.05), while the concentrations of blood urea nitrogen (BUN), c-reactive protein (CRP), potassium (K+), lactate dehydrogenase (LDH), lipid peroxide (LPO), and norepinephrine (NE) were significantly lower (p < 0.05) in heat-stressed animals as compared to the control group. A significant (p < 0.05) increase in the concentrations of cortisol (COR), corticosterone (CORT), and potassium (K+) was observed (p < 0.05), while the concentrations of adrenocorticotrophic hormone (ACTH), dopamine (DA), GH, LDH, NE, PRL, and SOD were significantly lower in cold-stressed animals as compared to the control group (p < 0.05). Furthermore, SNP A-12G and C181T were significantly associated with LA (p < 0.05), while A72G was linked with LPO (p < 0.05) in heat-stressed animals. Moreover, the SNPs A-12G and SNP C131G were significantly associated (p < 0.05) with DA and SOD under cold stress condition, respectively. These SNPs markers significantly associated with fluctuations in blood biochemical parameters under thermal stress provide a better insight into the genetic mechanisms underlying climatic resilience in Holstein cattle.

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“…Heat stress affects the oxidative stressrelated physiological status in females as well as males. Heat stress caused increases in oxidative markers, such as the levels of TBARS, superoxide dismutase (SOD) and catalase in plasma and erythrocytes in humans [126], cows [127], goats [128] and mice [129], and in the liver in rats [130]. Maternal heat stress changes the redox status in the oviduct in mice [75,129].…”

Section: Oxidative Stress In Heat Stressed Reproductive Functionsmentioning

confidence: 99%

Heat stress on reproductive function and fertility in mammals

Takahashi

2011

Reprod Medicine & Biology

106

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In most mammalian species including cattle, heat stress has deleterious effects on nutritional, physiological and reproductive functions. Exposure of animals to a hot environment causes an increase in body temperature in mammals, including domestic animals. High ambient temperature also causes a decrease in the length and intensity of estrus by disturbing ovarian function as well as decreasing pregnancy rate after artificial insemination. Therefore, it is important to understand the effects of heat stress on reproductive function in order to improve the production of domestic animals. Heat stress decreases appetite, weight gain, and milk yield in dairy cattle. It also adversely affects the reproductive performance of both sexes. In males, it reduces spermatogenic activity, while in females it adversely impacts oogenesis, oocyte maturation, fertilization development and implantation rate. Detection and evaluation of the deteriorating effects of heat stress on reproductive organs and cells can help to design measures to prevent them and improve reproductive functions. In this review, we discuss the impacts of heat stress on reproductive functions.

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Effect of heat stress on endotoxin flux across mesenteric-drained and portal-drained viscera of dairy goat

Cited by 15 publications

References 19 publications

Short-term exposure to heat stress attenuates appetite and intestinal integrity in growing pigs1

Short-term exposure to heat stress attenuates appetite and intestinal integrity in growing pigs1

Association Analysis of Polymorphisms in the 5′ Flanking Region of the HSP70 Gene with Blood Biochemical Parameters of Lactating Holstein Cows under Heat and Cold Stress

Heat stress on reproductive function and fertility in mammals

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