Effect of heat stress on brain 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in some vertebrate species

Mohamed, Mohamed Ismail; Rahman, Taghride Abdel

doi:10.1016/0306-4492(82)90127-7

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…Calves under chronic heat stress had reduced HSP70 mRNA expression in peripheral blood leukocytes when compared to CL calves. The expression of HSP70 is induced under heat stress conditions; it functions as a chaperone protein that prevents unfolding [ 43 ] and can promote the degradation of defective proteins [ 24 , 44 ]. Collier et al .…”

Section: Discussionmentioning

confidence: 99%

“…Serotonin has also been extensively studied for its role in adaptive responses to physical, metabolic, and environmental stressors, primarily in humans and rodents [21][22][23][24][25][26][27]. For instance, rodents exposed to acute heat stress have increased 5-HT concentrations in the brain [24] and in peripheral circulation [23], suggesting that 5-HT plays a role in thermoregulation. Prolonged stress exposure, due to light cycle alterations and temperature fluctuations, induce apoptosis of 5-HT-expressing neurons in the dorsal raphe in rodents [28].…”

Section: Introductionmentioning

confidence: 99%

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Chronic heat stress delays immune system development and alters serotonin signaling in pre-weaned dairy calves

et al. 2021

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Exposure to heat stress can alter the development and immune system function in dairy calves. Serotonin is an immunomodulatory biogenic amine that functions as a neurotransmitter and as a stress-response mediator. Our objectives were to characterize the patterns of serum serotonin concentrations and the pattern of serotonin-related genes expressed by immune cells of calves exposed to chronic heat stress or heat stress abatement during early life, and to explore whether these might relate to immune system development. Dairy calves were exposed to chronic heat stress (HS; n = 6) or heat stress abatement (cooling, CL; n = 6) across the prenatal (late gestation, last 46 d) and postnatal (from birth to weaning, 56 d) developmental windows. Blood samples were collected to harvest serum (weekly, from d 1 to 49), to isolate of circulating leukocyte mRNA (at 1, 21 and 42 d of age) and characterize immune cell populations by flow cytometry (at 21 and 47 d of age). Calves exposed to chronic heat stress pre- and postnatally had lower red blood cell counts and lower circulating serotonin, immunoglobulin G, and B-lymphocytes compared to CL calves. Circulating blood leukocyte mRNA expression of serotonin receptors -1A, -1F, -4 and -5 was greater, while heat shock protein 70 and immune-related genes (i.e., TBX21, TLR4, and TGFβ) were lower in HS relative to CL calves. Peripheral blood leukocytes from all calves secreted serotonin and interleukin-6 after in-vitro lipopolysaccharide stimulation. However, the HS calves produced more serotonin and less interleukin-6 than CL calves when activated in-vitro. Together, our data suggest that providing heat stress abatement to dairy calves across prenatal and postnatal developmental windows might modulate the serotonin synthesis pathway in ways that may benefit humoral immunity against microbial pathogens.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic heat stress delays immune system development and alters serotonin signaling in pre-weaned dairy calves

et al. 2021

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“…An explanation for this might be the differing degrees to which core temperature had risen from baseline, and Brisson et al (1991) argued that a certain body temperature threshold must be reached for heat loads to induce significant changes in blood prolactin. Prolactin release from the anterior pituitary is primarily stimulated by 5-HT receptor activation (Eison & Temple, 1986), and an increased deep body temperature has been shown to increase brain 5-HT concentration in animals (Mohamed & Rahman, 1982;Dey et al 1993), with similar effects likely in man. In the present study, passive warming in the CON condition resulted in a significant rise in circulating prolactin, despite a rise in rectal temperature of only 0.23 ± 0.03 • C after 60 min at an ambient temperature of 58 • C. It seems unlikely that such a small rise in core temperature would stimulate this response, since Follenius et al (1979) observed no effect on plasma prolactin during 90 min of heat exposure during which rectal temperature increased by nearly three times the level we observed (0.65 • C).…”

Section: Influence Of Core and Skin Temperaturesmentioning

confidence: 99%

The effects of face cooling on the prolactin response and subjective comfort during moderate passive heating in humans

Mündel¹,

Hooper²,

Bunn³

et al. 2006

Experimental Physiology

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The purpose of the present study was twofold: first, to determine the extent to which elevated skin temperature is responsible for the hormonal and perceptual responses to passive heating; and second, to determine to what extent face-cooling can override the effects of raised skin temperature. Sixteen recreationally active, non-heat-acclimated volunteers (12 male, 4 female; age, 29 ± 9 years, [mean ± S.D.]) underwent a passive heat exposure for 60 min in a sauna maintained at 58 • C (13% relative humidity), conditions under which sweating effectively maintains core temperature. Subjects were allocated to one of two experimental groups which were matched for sex, age, body mass index, body surface area and sweating response; one group received face cooling (FC) every 5 min, whilst the other control group (CON) received none. Mean skin temperatures were elevated by ∼4 • C for the 60 min duration (CON, 36.5 ± 0.1 • C; FC, 35.7 ± 0.1 • C; P < 0.05) but core temperature rose by only ∼0.25 • C with no difference between groups. Circulating prolactin remained stable and showed no increase for the FC group, whereas concentrations increased by 102 ± 34% (P < 0.05) for the CON group. No differences were observed between groups for heart rate, but the sensation of heat was less (P < 0.05) with FC. We suggest that a significant component of the prolactin response to moderate passive heating is mediated by facial skin temperature, and selective cooling of the face is associated with improved perception of thermal comfort. These results indicate that the temperature of only a small part of the total skin area (∼10%) has a disproportionately large effect on the hormonal and perceptual responses to heat stress.

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“…Accordingly, the sensitivity to other neurotransmitters or drugs for Cobb seems to be different from Ross Chunky a n d these differences may counterbalance hypophagia by serotonergic systems. w e n birds are under a heat stress, 5-HT levels increase in the several brain regions and which activates heat-loss mechanisms (Mohamed and Rahman, 1982). This fact leads to an idea that there may be difference in heat adaptation between the two strains used here, suggesting that rearing Ross Chunky is beneficial for an efficient production under heat stress, since this strain showed the resistant for central 5-HT.…”

Section: Resultsmentioning

confidence: 82%

Role of Central Serotonergic Systems on the Regulation of Feeding Behavior of Chicks in Two Different Strains

Sashihara¹,

Bungo²,

Ando³

et al. 2002

Journal of Applied Animal Research

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Effect of heat stress on brain 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in some vertebrate species

Cited by 9 publications

References 16 publications

Chronic heat stress delays immune system development and alters serotonin signaling in pre-weaned dairy calves

Chronic heat stress delays immune system development and alters serotonin signaling in pre-weaned dairy calves

The effects of face cooling on the prolactin response and subjective comfort during moderate passive heating in humans

Role of Central Serotonergic Systems on the Regulation of Feeding Behavior of Chicks in Two Different Strains

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