Effect of heavy metal and some trace element levels on radiotherapy taken breast cancer patients

Demır, Halit; Demir, Canan

doi:10.17546/msd.55299

Cited by 4 publications

(8 citation statements)

References 28 publications

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“…In this study on lip and oral cavity cancers, the difference between Zn levels and the mean of control group was statistically significant (p <0.05). In our study, the level of zinc in the blood of patients with lip and oral cavity cancer was found to be significantly lower than in the healthy control group (Table I) In a literature study, it was reported that osteoblast-like cells can be transformed into carcinogenic phenotype in individuals exposed to Co, and they also activate the expression of genes associated with cancer [19]. Schnorr et al (1995) reported that cobalt was associated with lung cancer [27].…”

Section: Conclusion and Discussionmentioning

confidence: 40%

“…In this study on lip and oral cavity cancers, the difference between the patient and control group mean in terms of Mg levels was found to be statistically significant (p <0.05). In our study, it was found that the level of Mg in the blood of patients with lip and oral cavity cancer was significantly lower than in the healthy control group (Table I) In a study on breast cancer patients, Zn, Cu, Se and Fe concentrations were found to be high [19]. In addition, Fe levels in breast cancer cases were found to be higher than control groups [19].…”

Section: Conclusion and Discussionmentioning

confidence: 43%

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Determining the Levels of Some Trace Elements and Heavy Metals (Cu, Mn, Mg, Fe, Zn, CO, Pb and CD) in the Cancers of Lip and Oral Cavity

Demir

2021

Preprint

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Aim: The aim of the study is to determine the relationship of some trace elements and heavy metals with lip and oral cavity cancer. Materials And Methods: Blood counts of 21 individuals with lip and oral cavity cancer were compared with those in the control group consisting of 30 volunteer and healthy subjects. Levels of trace elements and heavy metals in the serum (Zn, Cu, Mg, Pb, Mn, Cd, Co and Fe) were determined using Atomic Absorption Spectrophotometer method at YUU Central Research Laboratory (Spectrometer: Thermo Scientific C103500100, China). Findings: In this study, the descriptive statistics and comparison results for Cu, Mn, Mg, Fe, Zn, Co, Pb, Cd were found to be statistically significant (p <0.05). According to these results, Zn, Fe, Mn, Mg and Cu levels which are necessary trace elements for human body were found to be significantly lower in patients than healthy control groups. Cd, Co and Pb levels which are harmful and toxic to human body were found to be significantly higher in patients than healthy control groups (p <0.05). Results: Based on these findings of this first and new study in the literature, it was concluded that, trace elements and heavy metals (Cu, Mn, Mg, Fe, Zn, Co, Pb and Cd) in the lip and oral cavity may affect the etiopathogenesis of the disease.

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Section: Conclusion and Discussionmentioning

confidence: 40%

Section: Conclusion and Discussionmentioning

confidence: 43%

Determining the Levels of Some Trace Elements and Heavy Metals (Cu, Mn, Mg, Fe, Zn, CO, Pb and CD) in the Cancers of Lip and Oral Cavity

Demir

2021

Preprint

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“…In a study on breast cancer, it was reported that the Cu and Mg levels in the blood of patients before and after radiotherapy were significantly different compared to the healthy control group [18]. In two different studies on breast cancer, it was reported that the Cu levels in the patients' blood were higher than the healthy control groups [19]. In this study on lip and oral cavity cancers, the difference between the mean levels of Cu and control group was statistically significant (p <0.05).…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Determination of some trace elements and heavy metal levels (Cu, Mn, Mg, Fe, Zn, Co, Pb, and Cd) in blood serum of patients with lip and oral cavity cancers

Demir¹,

Demır²,

Bozan³

et al. 2023

J. Elem.

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“…Trace elements, while present in very minute quantities, play a very important role in human health. The rise in heavy metals results in increased oxidative stress, which is correlated with higher cancer risk( [27]). For patients with diabetes and heart disease, elevated levels of Arsenic cause damage to the nerve cells and blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Trace Elements Levels and Lung Cancer Patients in Southern Iraq

Abduljaleel

Abdulhaleem²

2022

AJRiZ

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Background: Our life relies on our ability to use all sorts of materials, like trace elements, in the world for our needs. The using of heavy metals has greatly contributed to the comfort of our everyday lives. Blood is directly affected by poisoning when such metals are inhaled from environments where heavy metals occur in high levels. Research is constantly advancing our knowledge of the connection between various trace elements and disease, particularly cancer, since the effects of heavy metals on human health remain a serious health concern. Objective: The objective of this work is to establish levels of a range of elements in human blood, serum and hair samples of patient undergo lung cancer comparing with control (healthy persons) so that potential exposures can be better identified in future cases. Methods: Elements concentrations including As(arsenic), Ba(barium), Co(cobalt), Li(lithium), Mg(magnesium), Mn(manganese), Mo(molybdenum), Rb(rubidium), Sr(strontium) and Ti(titanium) was analysis used MS ICP (an inductively coupled plasma atomic absorption spectrophotometer). Results: Test found that Mn has substantially (p<0.05) high concentration in three tissues including whole blood, serum, and hair of patients with lung cancer (291,487.2,68.03) ug / l respectively. In comparison as occurs in the lowest concentration. Sr was 77.5ug / l, Rb 41.6ug / l, and Ba 35.2ug / g. On other hand, Co, Li, Mg, Mo and Ti were found in low levels ranged 1.7-5.5 ug/l, in whole blood of patients. Hair samples accumulated the lowest concentration of As, Ba, Co, Mg, Mn and Rb. When we compare the concentration of trace elements between lung patients and control samples, that clear most of the elements accumulate at high levels in lung cancer patients. Result found significantly high As, Ba, Co, Mg, Mo concentration in whole blood and serum of lung cancer patients, in contract, Li, Mn and Rb occur in high levels in whole blood of control sample. Even as hair of control samples have elevated levels of As, Sr and Ti. However, concentrations of trace elements in the whole blood of smokers and non-smokers showed that all ten elements accumulated at elevated levels in the blood of smokers relative to non-smokers. Spearman correlation found significantly positive correlation among trace elements in the blood of patients with smoker lung cancer and non-smokers. Conclusion: The study conclude that trace metals level in smokers persons are elevated than non-smokers. The findings of this study lend some support to the link between heavy metals pollution and lung cancer cases.

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Effect of heavy metal and some trace element levels on radiotherapy taken breast cancer patients

Cited by 4 publications

References 28 publications

Determining the Levels of Some Trace Elements and Heavy Metals (Cu, Mn, Mg, Fe, Zn, CO, Pb and CD) in the Cancers of Lip and Oral Cavity

Determining the Levels of Some Trace Elements and Heavy Metals (Cu, Mn, Mg, Fe, Zn, CO, Pb and CD) in the Cancers of Lip and Oral Cavity

Determination of some trace elements and heavy metal levels (Cu, Mn, Mg, Fe, Zn, Co, Pb, and Cd) in blood serum of patients with lip and oral cavity cancers

Relationship between Trace Elements Levels and Lung Cancer Patients in Southern Iraq

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