Effect of Helicobacter pylori and Helminth Coinfection on the Immune Response to Mycobacterium tuberculosis

Bustamante-Rengifo, Javier Andrés; Astudillo-Hernández, Miryam; Crespo-Ortiz, María del Pilar

doi:10.1007/s00284-021-02604-8

Cited by 5 publications

(6 citation statements)

References 105 publications

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“…Current estimates are that about one-third of the world population is infected by M. tuberculosis. Nevertheless, infected people without active disease are considered latent TB cases [53].…”

Section: H Pylori Infection and Tuberculosismentioning

confidence: 99%

“…This compromises CD4 + T cell-activation which could affect susceptibility to acquiring M. tuberculosis. In the second model, regulatory T (Treg) cells induced by H. pylori could downregulate Th1 and Th17 responses, thus affecting host immunity against M. tuberculosis [53]. Increased predisposition to H. pylori infection and enhanced mycobacterial survival and replication, hypothesized in TB patients, may be sustained by the same HLA-DQ serotype, hence inducing susceptibility to both bacteria [59,60].…”

Section: H Pylori Infection and Tuberculosismentioning

confidence: 99%

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Helicobacter pylori and Respiratory Diseases: 2021 Update

et al. 2021

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Helicobacter pylori (H. pylori) is a Gram-negative bacterium involved in the development of gastritis, peptic ulcer disease, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue. Unexplained iron deficiency anemia, idiopathic thrombocytopenic purpura and vitamin B12 deficiency have also been related to H. pylori infection, whereas for other extra-gastric diseases, the debate is still open. In this review, we evaluate and discuss the potential involvement of H. pylori infection in the pathogenesis of several respiratory diseases. A MEDLINE search of all studies published in English from 1965 to 2021 was carried out. Controversial findings have been reported in patients with bronchial asthma, chronic obstructive pulmonary disease, bronchiectasis, lung cancer, tuberculosis, cystic fibrosis, and sarcoidosis. Most of the available literature is concerned with case-control studies based on seroprevalence, with a small sample size and low consideration of confounders, which represents a potential issue. So far, there is no clear evidence of a causal association between H. pylori infection and respiratory diseases, and larger studies with appropriate epidemiological design are required.

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Section: H Pylori Infection and Tuberculosismentioning

confidence: 99%

Section: H Pylori Infection and Tuberculosismentioning

confidence: 99%

Helicobacter pylori and Respiratory Diseases: 2021 Update

et al. 2021

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“…However, these results contradict the results of three studies which found no association between Mtb and H. pylori ( Sanaka et al, 1998 ; Tsang et al, 1998 ; Torres et al, 2003 ), and three studies that found that H. pylori increased the incidence of Mtb infections ( Mitchell et al, 1992 ; Woeltje et al, 1997 ; Philippou et al, 2003 ). H. pylori may worsen TB through its ability to increase Treg populations, interfere with DC maturation and prevent T lymphocyte maturation ( Bustamante-Rengifo et al, 2021 ). However, the exact relationship between H. pylori and Mtb remains to be fully elucidated through larger studies with appropriate controls.…”

Section: The Gut-lung Axis In Mycobacterium Tuberculosis ...mentioning

confidence: 99%

Impact of the gut-lung axis on tuberculosis susceptibility and progression

Enjeti,

Sathkumara,

Kupz

2023

Front. Microbiol.

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Tuberculosis (TB) has remained at the forefront of the global infectious disease burden for centuries. Concerted global efforts to eliminate TB have been hindered by the complexity of Mycobacterium tuberculosis (Mtb), the emergence of antibiotic resistant Mtb strains and the recent impact of the ongoing pandemic of coronavirus disease 2019 (COVID19). Examination of the immunomodulatory role of gastrointestinal microbiota presents a new direction for TB research. The gut microbiome is well-established as a critical modulator of early immune development and inflammatory responses in humans. Recent studies in animal models have further substantiated the existence of the ‘gut-lung axis’, where distal gastrointestinal commensals modulate lung immune function. This gut microbiome-lung immune crosstalk is postulated to have an important correlation with the pathophysiology of TB. Further evaluation of this gut immunomodulation in TB may provide a novel avenue for the exploration of therapeutic targets. This mini-review assesses the proposed mechanisms by which the gut-lung axis impacts TB susceptibility and progression. It also examines the impact of current anti-TB therapy on the gut microbiome and the effects of gut dysbiosis on treatment outcomes. Finally, it investigates new therapeutic targets, particularly the use of probiotics in treatment of antibiotic resistant TB and informs future developments in the field.

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“…Furthermore, H. pylori induces the secretion of IL-10 through the regulatory T cell (Treg) network, which helps control local inflammation and maintain immune homeostasis. This immune response is particularly pronounced in infections with cagA+/vacA s1m1 strains, and co-infection with H. pylori and helminths can also increase susceptibility to tuberculosis due to dysregulated immune responses ( Bustamante-Rengifo et al, 2021 ). These immune mechanisms contribute to the complex interactions between H. pylori and various infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

CagA-positive Helicobacter pylori may promote and aggravate scrub typhus

Du,

Zeng,

Pang

et al. 2024

Front. Microbiol.

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Helicobacter pylori (H. pylori) infection may alter the host’s resistance to tsutsugamushi disease pathogens through the Th1 immune response, leading to potential synergistic pathogenic effects. A total of 117 scrub typhus cases at Beihai People’s Hospital and affiliated hospitals of Youjiang University for Nationalities and Medical Sciences were studied from January to December 2022, alongside 130 healthy individuals forming the control group. All participants underwent serum H. pylori antibody testing. The prevalence of H. pylori infection was significantly higher among scrub typhus patients (89.7%) compared to healthy individuals (54.6%) (p < 0.05). Moreover, type I H. pylori infection was notably more prevalent in scrub typhus cases (67.5%) compared to healthy individuals (30%) (p < 0.05). Multifactorial analysis demonstrated type I H. pylori infection as an independent risk factor for scrub typhus (adjusted odds ratio: 2.407, 95% confidence interval: 1.249–4.64, p = 0.009). Among scrub typhus patients with multiple organ damage, the prevalence of type I H. pylori infection was significantly higher (50.6%) than type II H. pylori infection (15.4%) (χ2 = 4.735, p = 0.030). These results highlight a higher incidence of H. pylori infection in scrub typhus patients compared to the healthy population. Additionally, type I H. pylori strain emerged as an independent risk factor for scrub typhus development. Moreover, individuals infected with type I H. pylori are more susceptible to multiple organ damage. These findings suggest a potential role of H. pylori carrying the CagA gene in promoting and exacerbating scrub typhus.

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Effect of Helicobacter pylori and Helminth Coinfection on the Immune Response to Mycobacterium tuberculosis

Cited by 5 publications

References 105 publications

Helicobacter pylori and Respiratory Diseases: 2021 Update

Helicobacter pylori and Respiratory Diseases: 2021 Update

Impact of the gut-lung axis on tuberculosis susceptibility and progression

CagA-positive Helicobacter pylori may promote and aggravate scrub typhus

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