Helicobacter pylori and Respiratory Diseases: 2021 Update

Durazzo, Marilena; Adriani, Alessandro; Fagoonee, Sharmila; Saracco, Giorgio Maria; Pellicano, Rinaldo

doi:10.3390/microorganisms9102033

Cited by 27 publications

(25 citation statements)

References 79 publications

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“…Iron levels and stomach health are closely interrelated. For example, several iron-related conditions, such as unexplained iron deficiency, idiopathic thrombocytopenic purpura, and anemia, were found to be associated with H. pylori infection ( Hagymási and Tulassay, 2014 ; Durazzo et al, 2021 ). Iron homeostasis has also been implicated in cancer development.…”

Section: Iron Metabolism In Gastric Cancermentioning

confidence: 99%

Ferroptosis and its Role in Gastric Cancer

Xia

et al. 2022

Front. Cell Dev. Biol.

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Gastric cancer (GC) is the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. Currently, surgery is the treatment of choice for GC. However, the associated expenses and post-surgical pain impose a huge burden on these patients. Furthermore, disease recurrence is also very common in GC patients, thus necessitating the discovery and development of other potential treatment options. A growing body of knowledge about ferroptosis in different cancer types provides a new perspective in cancer therapeutics. Ferroptosis is an iron-dependent form of cell death. It is characterized by intracellular lipid peroxide accumulation and redox imbalance. In this review, we summarized the current findings of ferroptosis regulation in GC. We also tackled on the action of different potential drugs and genes in inducing ferroptosis for treating GC and solving drug resistance. Furthermore, we also explored the relationship between ferroptosis and the tumor microenvironment in GC. Finally, we discussed areas for future studies on the role of ferroptosis in GC to accelerate the clinical utility of ferroptosis induction as a treatment strategy for GC.

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Section: Iron Metabolism In Gastric Cancermentioning

confidence: 99%

Ferroptosis and its Role in Gastric Cancer

Xia

et al. 2022

Front. Cell Dev. Biol.

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“…H. pylori infection induced lung injury via increasing the expression of inflammatory mediators using a mouse model [ 8 ]. H. pylori stimulates immune response and long-term inflammation which may be one of the causes of lung injury in the human body [ 12 ]. H. pylori infection activated NF-κB signaling pathway leading to the deleterious gastric pathophysiology and gastric diseases [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori promotes inflammatory factor secretion and lung injury through VacA exotoxin-mediated activation of NF-κB signaling

et al. 2022

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Previous reports have shown that Helicobacter pylori ( H. pylori ) infection is associated with respiratory diseases. However, the pathogenesis remains unclear. Vacuolating cytotoxin A (VacA) is a major H. pylori exotoxin. In this study, we investigated the signaling pathways involved in the inflammatory response to H. pylori infection and VacA. Mice were treated with H. pylori and VacA, and histopathological analysis of lung tissues was performed using hematoxylin-eosin, Masson’s trichrome, and periodic acid Schiff staining. The secretion of inflammatory cytokines was evaluated by enzyme-linked immunosorbent assay. The expression of VacA, nuclear factor-kappa B (NF-κB), and p65 NF-κB was analyzed by Western blotting and immunofluorescence. Cell proliferation and apoptosis were assessed using the MTS assay and flow cytometry, respectively. In mice, H. pylori infection and VacA treatment promoted the secretion of the inflammatory factors interleukin 1β (IL-1β), tumor necrosis factor α (TNF-α), IL-6, and IL-8, increased p65 NF-κB protein phosphorylation, and induced lung injury. Furthermore, H. pylori infection promoted VacA production. In an in vitro cell model, VacA treatment significantly suppressed the proliferation of WI-38 and BEAS-2B cells, promoted apoptosis, induced TNF-α, IL-1β, IL-6, and IL-8 secretion, and promoted p65 NF-κB protein phosphorylation and NF-κB nuclear transfer. The NF-κB inhibitor BAY11-7082 alleviated VacA-induced inflammation and apoptosis and increased cell viability. In conclusion, VacA promotes the secretion of inflammatory factors and induces lung injury through NF-κB signaling.

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“…Helicobacter pylori (H. pylori) are a widespread bacterial infection among individuals worldwide. This bacterium is a Gram-negative flagellated bacterium that is found in around 50 percent of western countries and more than 80 percent of persons living in poor countries (1). Inflammation in human stomach mucosa and longterm colonisation of H. pylori is considered the main cause of persistent infection (2) and its helix shape is believed to have evolved to allow it to pierce the mucoid lining of the stomach (3).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of H. Pylori Infection among Patients with Recurrent Gastric Ulcer in Arbil City

Azeez¹,

Yassin²,

Yassin³

2022

PJMHS

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Aim: This study's goal is to identify the prevalence of H. pylori infection among patients with recurrent gastric ulcers in Arbil, Iraq. Study design: A cross-sectional study Place & duration of the study: From Oct 2021 to Feb 2022 in the private laboratories in Arbil city/Iraq. Methodology: A total of 83 patients with recurrent gastric ulcers were admitted to the private laboratories in Arbil city. Blood samples were collected for detection of anti-Helicobacter pylori antibodies IgG and IgA in patient serum samples by the serological method by Enzyme-linked immunosorbent assays. A special questionnaire sheet was designed and used for each patient subject. Results: Among 83 screened samples, the overall seroprevalence rate of H. pylori infection patients with recurrent gastric ulcer was 47 (56.6%). H. pylori infection was more common in female patients (59.1%) compared to male patients (53.8%). The rate of Helicobacter pylori infection was higher (84.2%) among the young adult-aged patient group (21-30) years, and (63.4%) in urban patients. A higher seropositive rate of H. pylori infection was among married patients (51.8%). Regarding marital status, most of the seropositive patients were among married patients (51.8%), (64%) among nonuse therapy, (56.7%) in the A blood group, (66.6%) among severe symptom patients, and (69.2%) among patients with a previous history of H. pylori infection respectively. Conclusions: Patients with recurrent stomach ulcers had greater levels of helicobacter pylori antibodies, which were linked to negative outcomes. Keywords: H. pylori, gastric ulcer, recurrent infection IgG, IgA

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Helicobacter pylori and Respiratory Diseases: 2021 Update

Cited by 27 publications

References 79 publications

Ferroptosis and its Role in Gastric Cancer

Ferroptosis and its Role in Gastric Cancer

Helicobacter pylori promotes inflammatory factor secretion and lung injury through VacA exotoxin-mediated activation of NF-κB signaling

Prevalence of H. Pylori Infection among Patients with Recurrent Gastric Ulcer in Arbil City

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