Ferroptosis and its Role in Gastric Cancer

Gu, Renjun; Xia, Yawen; Li, Pengfei; Zou, Defang; Lu, Keqin; Ren, Lang; Zhang, Hongru; Sun, Ziying

doi:10.3389/fcell.2022.860344

Cited by 36 publications

(30 citation statements)

References 115 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ferroptosis is a newly identified programmed cell death, typically characterized by free iron overload and lethal phospholipid peroxide generation. Increasing evidence has demonstrated that inducing ferroptosis represents a promising therapeutic strategy that preferentially targets iron-rich cancer cells such as HCC [ 67 , 68 ], NSCLC [ 69 ], PDAC [ 70 ], leukemia [ 38 ] and GC [ 71 , 72 ], and provides insights into reversing drug resistance in cancers. The mitochondrial electron transport chain is responsible for ATP production.…”

Section: Discussionmentioning

confidence: 99%

Identification of mitochondrial respiratory chain signature for predicting prognosis and immunotherapy response in stomach adenocarcinoma

Yang

Jin

et al. 2023

Cancer Cell Int

View full text Add to dashboard Cite

Stomach adenocarcinoma (STAD) is the third leading cause of cancer-related deaths and the fifth most prevalent malignancy worldwide. Mitochondrial respiratory chain complexes play a crucial role in STAD pathogenesis. However, how mitochondrial respiratory chain complex genes (MRCCGs) affect the prognosis and tumor microenvironment in STAD remains unclear. In this study, we systematically analyzed genetic alterations and copy number variations of different expression densities of MRCCGs, based on 806 samples from two independent STAD cohorts. Then we employed the unsupervised clustering method to classify the samples into three expression patterns based on the prognostic MRCCG expressions, and found that they were involved in different biological pathways and correlated with the clinicopathological characteristics, immune cell infiltration, and prognosis of STAD. Subsequently, we conducted a univariate Cox regression analysis to identify the prognostic value of 1175 subtype-related differentially expressed genes (DEGs) and screened out 555 prognostic-related genes. Principal component analysis was performed and developed the MG score system to quantify MRCCG patterns of STAD. The prognostic significance of MG Score was validated in three cohorts. The low MG score group, characterized by increased microsatellite instability-high (MSI-H), tumor mutation burden (TMB), PD-L1 expression, had a better prognosis. Interestingly, we demonstrated MRCCG patterns score could predict the sensitivity to ferroptosis inducing therapy. Our comprehensive analysis of MRCCGs in STAD demonstrated their potential roles in the tumor-immune-stromal microenvironment, clinicopathological features, and prognosis. Our findings highlight that MRCCGs may provide a new understanding of immunotherapy strategies for gastric cancer and provide a new perspective on the development of personalized immune therapeutic strategies for patients with STAD.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of mitochondrial respiratory chain signature for predicting prognosis and immunotherapy response in stomach adenocarcinoma

Yang

Jin

et al. 2023

Cancer Cell Int

View full text Add to dashboard Cite

show abstract

“…This is also a hallmark of ferroptosis ( Conrad and Pratt, 2019 ). This reaction not only damages lipids and proteins but also causes oxidative damage to DNA, including DNA base modifications and DNA strand breaks ( Gu et al, 2022 ; Wu et al, 2022 ). While an iron overload does not always induce ferroptosis, it will enhance cell death when it occurs.…”

Section: The Underlying Mechanisms Of Ferroptosis In Ichmentioning

confidence: 99%

Ferroptosis: Underlying mechanism and the crosstalk with other modes of neuronal death after intracerebral hemorrhage

Cao

Xiao²,

Liu³

et al. 2023

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Intracerebral hemorrhage (ICH) is a serious cerebrovascular disease with high rates of morbidity, mortality, and disability. Optimal treatment of ICH is a major clinical challenge, as the underlying mechanisms remain unclear. Ferroptosis, a newly identified form of non-apoptotic programmed cell death, is characterized by the iron-induced accumulation of lipid reactive oxygen species (ROS), leading to intracellular oxidative stress. Lipid ROS causes damage to nucleic acids, proteins, and cell membranes, eventually resulting in ferroptosis. In the past 10 years, ferroptosis has resulted in plenty of discoveries and breakthroughs in cancer, neurodegeneration, and other diseases. Some studies have also reported that ferroptosis does occur after ICH in vitro and in vivo and contribute to neuronal death. However, the studies on ferroptosis following ICH are still in the preliminary stage. In this review, we will summarize the current evidence on the mechanism underlying ferroptosis after ICH. And review the traditional modes of neuronal death to identify the crosstalk with ferroptosis in ICH, including apoptosis, necroptosis, and autophagy. Additionally, we also aim to explore the promising therapeutic application of ferroptosis in cell death-based ICH.

show abstract

“…Ferroptosis plays a role in the development and progression of many diseases, including cancer, necroinflammatory disorders, and many organ damages and degenerative changes ( Jiang et al, 2021 ). Previous studies have revealed the important role of ferroptosis in GC ( Zhang et al, 2020 ; Liu et al, 2021 ; Gu et al, 2022 ). Ferroptosis plays an important regulatory role in the development of malignant tumors such as proliferation, invasion and metastasis of GC ( Guan et al, 2022 ; Lu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Identification and verification of ferroptosis-related genes in gastric intestinal metaplasia

Song

Zhang

et al. 2023

Front. Genet.

View full text Add to dashboard Cite

Background: Gastric intestinal metaplasia (IM) is the key link of gastric precancerous lesions. Ferroptosis is a novel form of programmed cell death. However, its impact on IM is unclear. The focus of this study is to identify and verify ferroptosis-related genes (FRGs) that may be involved in IM by bioinformatics analysis.Materials and methods: Differentially expressed genes (DEGs) were obtained from microarray dataset GSE60427 and GSE78523 downloaded from Gene Expression Omnibus (GEO) database. Differentially expressed ferroptosis-related genes (DEFRGs) were obtained from overlapping genes of DEGs and FRGs got from FerrDb. DAVID database was used for functional enrichment analysis. Protein-protein interaction (PPI) analysis and Cytoscape software were used to screen hub gene. In addition, we built a receiver operating characteristic (ROC) curve and verified the relative mRNA expression by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Finally, the CIBERSORT algorithm was used to analyze the immune infiltration in IM.Results: First, a total of 17 DEFRGs were identified. Second, a gene module identified by Cytoscape software was considered as hub gene: PTGS2, HMOX1, IFNG, and NOS2. Third, ROC analysis showed that HMOX1 and NOS2 had good diagnostic characteristics. qRT-PCR experiments confirmed the differential expression of HMOX1 in IM and normal gastric tissues. Finally, immunoassay showed that the proportion of T cells regulatory (Tregs) and macrophages M0 in IM was relatively higher, while the proportion of T cells CD4 memory activated and dendritic cells activated was lower.Conclusion: We found significant associations between FRGs and IM, and HMOX1 may be diagnostic biomarkers and therapeutic targets for IM. These results may enhance our understanding of IM and may contribute to its treatment.

show abstract

Ferroptosis and its Role in Gastric Cancer

Cited by 36 publications

References 115 publications

Identification of mitochondrial respiratory chain signature for predicting prognosis and immunotherapy response in stomach adenocarcinoma

Identification of mitochondrial respiratory chain signature for predicting prognosis and immunotherapy response in stomach adenocarcinoma

Ferroptosis: Underlying mechanism and the crosstalk with other modes of neuronal death after intracerebral hemorrhage

Identification and verification of ferroptosis-related genes in gastric intestinal metaplasia

Contact Info

Product

Resources

About