Effect of helium‐neon and infrared laser irradiation on wound healing in rabbits

Braverman, Berton; McCarthy, Robert J.; Ivankovich, Anthony D.; Forde, Danon E.; Overfield, Michael; Bapna, Mahapna S.

doi:10.1002/lsm.1900090111

Cited by 192 publications

(127 citation statements)

References 14 publications

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“…22,40,41 Polarized light may reproduce nearly 80% of the effects of the laser, but nonpolarized light may not.42 Polarization has also been suggested as an important factor on tissue responses.26,43 Despite earlier reports suggesting that laser light may inhibit or have no effect on wound healing, meticulous analysis of evidence and problems on the parameters used30,44-48 or consequence of the systemic effect of the laser therapy remain. 49,50 It is important to consider that the use of coherent and incoherent light results in different effects on living tissues and most studies suggested that the use of coherent light achieves better results.13 Considering that semiconductor lasers are coherent and mostly partially polarized, when the laser beam reaches the surface it becomes further polarized due to the formation of laser speckles. The degree of polarization decreases in a direct relationship of the depth of penetration within the tissues.…”

Section: Discussionmentioning

confidence: 99%

Polarized Light (400–2000 nm) and Non-ablative Laser (685 nm): A Description of the Wound Healing Process Using Immunohistochemical Analysis

Pinheiro

Pozza

Oliveira

et al. 2005

Photomedicine and Laser Surgery

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Objective: This study aimed to describe, through morphologic and cytochemical analysis, the healing process of wounds submitted (or not) to laser therapy (λ685 nm) or polarized light (λ400-2000 nm). Background Data: There are many reports on different effects of several types of phototherapies on the treatment of distinct conditions, amongst them, on wound healing. Laser therapy and the use of polarized light are still controversial despite successive reports on their positive effects on several biological processes. Methods: Thirty male Wistar rats, approximately 4 months old, were used, and standardized excisional wounds were created on their dorsum. The wounds were irradiated in four equidistant points with laser light or illuminated with polarized light, both with doses of 20 or 40 J/cm2. Group 1 acted as untreated controls. Animals were irradiated every 48 h during 7 days, starting immediately after surgery, and were humanely killed on the 8th post-operative day. Specimens were taken and routinely processed and stained with H&E, and for descriptive analysis of myofibroblasts and collagen fibers, the specimens were imunnomarked by smooth muscle α-actin and picrosirius stain. Results: Control specimens showed the presence of ulceration, hyperemia, discrete edema, intense, and diffuse inflammation, collagen deposition was irregular, and myofibroblasts were seen parallel to the wound margins. Wounds treated by laser therapy with a dose of 20 J/cm2 showed mild hyperemia, inflammation varied from moderate to intense, the number of fibroblasts was large, and the distribution of collagen fibers was more regular. Increasing the dose to 40 J/cm2 evidenced exuberant neovascularization, severe hyperemia, moderate to severe inflammation, large collagen deposition, and fewer myofibroblasts. On subjects illuminated with polarized light with a dose of 20 J/cm2, mild to moderate hyperemia was detectable, and collagen matrix was expressive and unevenly distributed; a larger number of myofibroblasts was present and no re-epithelialization was seen. Increasing the dose resulted in mild to moderate hyperemia, no reepithelialization was seen, edema was discrete, and inflammation was moderate. Conclusion: The use of 685-nm laser light or polarized light with a dose of 20 J/cm2 resulted in increased collagen deposition and better organization on healing wounds, and the number of myofibroblast was increased when polarized light is used.

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Section: Discussionmentioning

confidence: 99%

Polarized Light (400–2000 nm) and Non-ablative Laser (685 nm): A Description of the Wound Healing Process Using Immunohistochemical Analysis

Pinheiro

Pozza

Oliveira

et al. 2005

Photomedicine and Laser Surgery

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“…Recently, some physical methods, including therapeutic ultrasound and laser treatments, were found to accelerate and facilitate wound healing and increase scar quality [4][5][6][7][8][9][10][11][12][13][14][15][16][17]. However, conflicting findings have been reported in some studies, and some investigators found no treatment effect on accelerating the repair of wounds [18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, some researchers concluded that some physical methods, including therapeutic ultrasound and laser treatments, accelerate and facilitate wound healing and increase scar quality [4][5][6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…Although some investigators saw no acceleration in the repair of wounds with ultrasound treatment [19][20][21], positive results and treatment effects have been reported in studies of ultrasound treatment on tendon injuries, lateral epicondylitis, and wound healing [4][5][6][7]22,23]. In addition, the beneficial effects of laser treatment on wound healing and qualified scar formation have been reported by numerous studies [10][11][12][13][14][15]17,24,25], including our previous study [26].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the effects of laser and ultrasound treatments on experimental wound healing in rats

Demir¹,

Yaray²,

Kırnap³

et al. 2004

JRRD

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-A randomized controlled study investigated the effects of ultrasound and laser treatments on wound healing in rats. The duration of the inflammatory phase decreased with both laser and ultrasound treatments; however, laser was more effec-tive than ultrasound, with more significant results. The prolifera-tion phase showed, for both treatments, an increase in the level of hydroxyproline and the number of fibroblasts, as well as stimula-tion of the collagen synthesis and the composition. Laser treat-ment was again more effective than ultrasound. The wound breaking strength was significantly higher with both treatments, and no statistically significant difference emerged between the laser and ultrasound groups, although laser treatment provided a much greater increase in the wound breaking strength than ultra-sound. Both treatments have beneficial effects on the inflamma-tory, proliferation, and maturation phases of wound healing. Both can be used successfully for decubitis ulcers and chronic wounds, in conjunction with conventional therapies such as debridement and daily wound caring. However, laser treatment was more effective than ultrasound in the first two phases of wound healing.

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“…Braverman et al (1989) comparou a cicatrização de lesões num mesmo animal, sendo que apenas uma ferida foi irradiada com laser.…”

Section: Discussionunclassified

Avaliação da terapia por laser de arsenito e gálio em tendinite de cavalos Puro Sangue Inglês de corrida

Mikail¹

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Effect of helium‐neon and infrared laser irradiation on wound healing in rabbits

Cited by 192 publications

References 14 publications

Polarized Light (400–2000 nm) and Non-ablative Laser (685 nm): A Description of the Wound Healing Process Using Immunohistochemical Analysis

Polarized Light (400–2000 nm) and Non-ablative Laser (685 nm): A Description of the Wound Healing Process Using Immunohistochemical Analysis

Comparison of the effects of laser and ultrasound treatments on experimental wound healing in rats

Avaliação da terapia por laser de arsenito e gálio em tendinite de cavalos Puro Sangue Inglês de corrida

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