Effect of hesperidin conjugated with golden nanoparticles on phagocytic activity: In vitro study

Waheeb, Hanaa M.; Sulaiman, Ghassan M.; Jabir, Majid S.

doi:10.1063/5.0000159

Cited by 21 publications

(4 citation statements)

References 21 publications

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“…Overall, AgNPs augmented BMDMs and phagocytosis activity due to IL-8 production. The increase in phagocytic activity is likely a consequence of the AgNPs containing chemical substances, which acted as immune stimulators and enhancers, leading to increases in the activity of BMDMs to engulf foreign bodies, such as bacterial strains [49]. A study by Fraser et al [50] verified effect of silver NP on circulating mature, CD16 bright /CD62L bright and immature, CD16 dim /CD62L bright neutrophils.…”

Section: Silver Nanoparticles Induce Phagocytic Cell Activitymentioning

confidence: 99%

Green synthesis of silver nanoparticles from Eriobotrya japonica extract: a promising approach against cancer cells proliferation, inflammation, allergic disorders and phagocytosis induction

Jabir

Hussien

Sulaiman

et al. 2021

Artificial Cells, Nanomedicine, and Biotechnology

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Nanoparticles (NPs) have biological activities like antibacterial, antifungal, drug delivery, immunomodulation and antitumor activities. The aim of the current study was to investigate some of biomedical applications of silver NP synthesis using extracts from leaves of Eriobotrya japonica. Colour changes, UV-visible spectroscopy, SEM, zeta potential, dynamic light scattering, FTIR and XRD were used to confirm AgNPs formation. The UV-vis spectrum absorption band was observed at almost 430 nm. The SEM image shows quasi-spherical shape of AgNPs. The zeta potential demonstrated the negative surface charge of NPs. FTIR results showed the functional groups of AgNPs. Crystalline nature of AgNPs was confirmed by XRD pattern. MTT assay was used to study the anti-proliferative activity against MCF-7 and HeLa cells. Apoptosis was tested using a DNA-fragmentation test, and expression of P 53 . AgNPs inhibited the proliferation of MCF-7 and HeLa cells, and reduced inflammation. Treatment with AgNPs significantly decreased allergic disorder. AgNPs stimulated the phagocytosis process in BMDMs. The results suggested that AgNPs could be a promising therapy for future and preventing inflammation, reduce allergic disorders and prevent bacterial infection through the up-regulation of phagocytosis. Hence, future work such as developed and improved NPs as adjuvants, immune-modulating substances and nano-drug delivery system is needed.

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Section: Silver Nanoparticles Induce Phagocytic Cell Activitymentioning

confidence: 99%

Green synthesis of silver nanoparticles from Eriobotrya japonica extract: a promising approach against cancer cells proliferation, inflammation, allergic disorders and phagocytosis induction

Jabir

Hussien

Sulaiman

et al. 2021

Artificial Cells, Nanomedicine, and Biotechnology

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“…Recently, a golden nanoparticle-conjugated hesperidin complex was produced and evaluated with respect to the stimulation of the activity of phagocytic cells [55]. The phagocytic index of the conjugated complex against Staphylococcus aureus bacteria was considerably higher (85%) in comparison with both gold nanoparticles (66%), hesperidin (51%) and untreated blood sample used as the control (20%), demonstrating its higher bioavailability.…”

Section: The Bioavailability Issuementioning

confidence: 99%

Review of Evidence Available on Hesperidin-Rich Products as Potential Tools against COVID-19 and Hydrodynamic Cavitation-Based Extraction as a Method of Increasing Their Production

et al. 2020

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Based on recent computational and experimental studies, hesperidin, a bioactive flavonoid abundant in citrus peel, stands out for its high binding affinity to the main cellular receptors of SARS-CoV-2, outperforming drugs already recommended for clinical trials. Thus, it is very promising for prophylaxis and treatment of COVID-19, along with other coexistent flavonoids such as naringin, which could help restraining the proinflammatory overreaction of the immune system. Controlled hydrodynamic cavitation processes showed the highest speed, effectiveness and efficiency in the integral and green aqueous extraction of flavonoids, essential oils and pectin from citrus peel waste. After freeze-drying, the extracted pectin showed high quality and excellent antioxidant and antibacterial activities, attributed to flavonoids and essential oils adsorbed and concentrated on its surface. This study reviews the recent evidence about hesperidin as a promising molecule, and proposes a feasible and affordable process based on hydrodynamic cavitation for the integral aqueous extraction of citrus peel waste resulting in hesperidin-rich products, either aqueous extracts or pectin tablets. The uptake of this process on a relevant scale is urged, in order to achieve large-scale production and distribution of hesperidin-rich products. Meanwhile, experimental and clinical studies could determine the effective doses either for therapeutic and preventive purposes.

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“…Briefly, Cells line was seeded with density(1×104)on the cover slide that was located at the12well plate with GNPs and Si-GNPs were added in triplicate at different concentrations, and then incubated for 72 h (IC50 concentration), were used to treat the cells in 96-well plates. After incubation 24 hours, washing with PBS (twice), and addition of 100 μL of AO/EtBr (5 min), fluorescence microscopy was applied for cell visualization [32].…”

Section: Test For Clonogenicitymentioning

confidence: 99%

Inhibition of Ovarian Cancer Cells Growth Using Gold Nanoparticles and Silica Coated Gold Nanoparticles: In-Vitro Study

2022

pnr

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This research aims to employ gold nanoparticles (GNPs) and silicon-coated GNPs (Si-GNPs) as in vitro cytotoxic drugs against ovarian carcinoma cells. UV-spectrophotometer was used to characterize gold nanoparticles. GNPs and Si-GNPs were applied to ovarian cancer cells at various doses, and their anti-proliferative activity was measured using the Methyl-Thiazolyl Tetrazolium (MTT) test. Acridine-Orange/ Ethidium-bromide AO/EB, a dual stain, was used to examine apoptotic cells; a Crystal violet stain was used to evaluate cancer cells colony formation. The findings indicated GNPs and Si-GNPs' capacity to cause apoptosis as a possible antitumor agent in and ovarian cancer cell line. According to the present results, GNPs and Si-GNPs might be employed for a variety of biological applications in the future, perhaps replacing chemotherapy in the treatment of several types of cancer disorders.

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Effect of hesperidin conjugated with golden nanoparticles on phagocytic activity: In vitro study

Cited by 21 publications

References 21 publications

Green synthesis of silver nanoparticles from Eriobotrya japonica extract: a promising approach against cancer cells proliferation, inflammation, allergic disorders and phagocytosis induction

Green synthesis of silver nanoparticles from Eriobotrya japonica extract: a promising approach against cancer cells proliferation, inflammation, allergic disorders and phagocytosis induction

Review of Evidence Available on Hesperidin-Rich Products as Potential Tools against COVID-19 and Hydrodynamic Cavitation-Based Extraction as a Method of Increasing Their Production

Inhibition of Ovarian Cancer Cells Growth Using Gold Nanoparticles and Silica Coated Gold Nanoparticles: In-Vitro Study

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