Effect of hexacosanol on the characteristics of novel sustained-release allopurinol solid lipospheres (SLS): factorial design application and product evaluation

El-Gibaly, I.; Abdel-Ghaffar, Sary

doi:10.1016/j.ijpharm.2004.12.027

Cited by 30 publications

(22 citation statements)

References 29 publications

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“…The microsponge sample was attached to the specimen holder using a doublecoated adhesive tape and was gold-coated (∼20-nm thickness) under vacuum using a sputter coater (Model JFC-1100, JEOL, Japan) for 5-10 min at 40 mA and then investigated at 30 kV (18).…”

Section: Scanning Electron Microscopymentioning

confidence: 99%

In Vitro and In Vivo Evaluation of Hydroxyzine Hydrochloride Microsponges for Topical Delivery

2011

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Abstract. Hydroxyzine HCl is used in oral formulations for the treatment of urticaria and atopic dermatitis. Dizziness, blurred vision, and anticholinergic responses, represent the most common side effects. It has been shown that controlled release of the drug from a delivery system to the skin could reduce the side effects while reducing percutaneous absorption. Therefore, the aim of the present study was to produce an effective drug-loaded dosage form that is able to control the release of hydroxyzine hydrochloride into the skin. The Microsponge Delivery System is a unique technology for the controlled release of topical agents, and it consists of porous polymeric microspheres, typically 10-50 μm in diameter, loaded with active agents. Eudragit RS-100 microsponges of the drug were prepared by the oil in an oil emulsion solvent diffusion method using acetone as dispersing solvent and liquid paraffin as the continuous medium. Magnesium stearate was added to the dispersed phase to prevent flocculation of Eudragit RS-100 microsponges. Pore inducers such as sucrose and pregelatinized starch were used to enhance the rate of drug release. Microsponges of nearly 98% encapsulation efficiency and 60-70% porosity were produced. The pharmacodynamic effect of the chosen preparation was tested on the shaved back of histamine-sensitized rabbits. Histopathological studies were driven for the detection of the healing of inflamed tissues.

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Section: Scanning Electron Microscopymentioning

confidence: 99%

In Vitro and In Vivo Evaluation of Hydroxyzine Hydrochloride Microsponges for Topical Delivery

2011

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“…Relevant human health benefits were found from even-long chain fatty alcohols: docosanol showed an anti-herpes virus activity 6 ; hexacosanol encapsulated in wall matrix of solid lipospheres provided the means to enhance the encapsulation efficiency of allopurinol 7 ; octacosanol showed an antiangiogenic action in preclinical set up 8 and an effect in decreasing of neutral sterol and bile acid concentration in feces 9 . In studies conducted on plants, triacontanol was proved to have an effective growth regulator in the micropropagation of Melissa officinalis L. 10 and in the Erythrina variegata protection from cadmium toxicity 11 .…”

Section: Introductionmentioning

confidence: 99%

Policosanol in Tomato (<i>Solanum lycopersicum</i> L.) Seed Oil: the Effect of Cultivar

Giuffré

Capocasale

2015

J. Oleo Sci.

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“…In addition to the art of formulation, the technique of factorial design is an efficient method of indicating the relative significance of a number of variables and their interactions [24]. The response surface method, first reported by Box and Wilson [25], has been applied to dosage form design for various kinds of drugs by several other researchers [26][27][28]. Factorial design is a very efficient tool to obtain an appropriate mathematical model with minimum experiments for the optimisation of formulation design.…”

Section: Introductionmentioning

confidence: 99%

Crystalline and amorphous carvedilol-loaded nanoemulsions: formulation optimisation using response surface methodology

Bhagat

Singh

Verma

et al. 2012

Journal of Experimental Nanoscience

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(2013) Crystalline and amorphous carvedilolloaded nanoemulsions: formulation optimisation using response surface methodology, Journal of Experimental Nanoscience, 8:7-8, 971-992, DOI: 10.1080/17458080.2011 This study aimed to evaluate the crystalline and amorphous carvedilol along with their lipidic mixtures using various instrumental techniques and to use response surface methodology in conjunction with factorial design to establish the functional relationships between operating variables (capmul GMS 50 K and cremophor RH 40). The response variables selected are spectroscopic absorbance (Y 1 ), mean particle size in distilled water (Y 2 ) and in phosphate buffer pH 6.8 (Y 3 ), polydispersibility index (PDI) (Y 4 ) and zeta potential (Y 5 ). The optimal formulations of crystalline and amorphous carvedilol-loaded nanoemulsions were composed of fixed levels, À0.41 and À0.42, of capmul GMS 50 K and cremophor RH 40, respectively. The predicted and observed values of Y 1 -Y 5 for blank nanoemulsions showed the percentage bias error of À12.12%, À10.25%, À18.47%, þ14.81 and À2.89, respectively. The bias percent ranged between À2.70% and À29.41% for the responses Y 1 -Y 4 for both crystalline and amorphous carvedilol-loaded nanoemulsions, indicating high degree of prognosis. However, the bias percent values for the response variable Y 5 were 294.2% and 262.6%, for the crystalline and amorphous carvedilol-loaded nanoemulsions, respectively, possibly due to cationisation of emulsion droplets. The transmission electron microscopy of selected optimal nanoemulsions showed the spherical shape of globules with no signs of coalescence and precipitation of drug. This study demonstrates the use of factorial design for the preparation of nanoemulsions of crystalline and amorphous carvedilol. The desirable goals can be obtained by systematic formulation approach in the shortest possible time.

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Effect of hexacosanol on the characteristics of novel sustained-release allopurinol solid lipospheres (SLS): factorial design application and product evaluation

Cited by 30 publications

References 29 publications

In Vitro and In Vivo Evaluation of Hydroxyzine Hydrochloride Microsponges for Topical Delivery

In Vitro and In Vivo Evaluation of Hydroxyzine Hydrochloride Microsponges for Topical Delivery

Policosanol in Tomato (<i>Solanum lycopersicum</i> L.) Seed Oil: the Effect of Cultivar

Crystalline and amorphous carvedilol-loaded nanoemulsions: formulation optimisation using response surface methodology

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