Effect of Hibiscus sabdariffa on obesity in MSG mice

Alarcón-Aguilar, Francisco Javier; Zamilpa, Alejandro; Pérez-García, Ma Dolores; Almanza-Perez, Julio César; Romero-Nuñez, Eunice; Campos-Sepúlveda, Efraín; Vazquez-Carrillo, Laura I.; Román-Ramos, Rubén

doi:10.1016/j.jep.2007.07.020

Cited by 150 publications

(102 citation statements)

References 25 publications

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“…This anti-obesity effect of HS has been confirmed by Alarcon-Aguilar et al (2007) when they observed significantly reduced body weight gain in monosodium glutamate-induced obese mice. It is not known, however, whether maternal consumption of HS during lactation will affect offspring postnatal weight gain.…”

Section: Introductionmentioning

confidence: 62%

Mechanism of delayed puberty in rats whose mothers consumedHibiscus sabdariffaduring lactation

Iyare¹,

Adegoke²,

Nwagha³

2010

Pharmaceutical Biology

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Section: Introductionmentioning

confidence: 62%

Mechanism of delayed puberty in rats whose mothers consumedHibiscus sabdariffaduring lactation

Iyare¹,

Adegoke²,

Nwagha³

2010

Pharmaceutical Biology

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“…MSG-obese mice have also been reported as a suitable model for diabetes (Nagata et al, 2006;Sasaki et al, 2009) and nonalcoholic liver steatosis (Sasaki et al, 2011;Franca et al, 2014;Fujimoto et al, 2014), conditions often treated by various drugs. Moreover, this model is used for nutritional intervention studies, such as effect of Hibiscus sabdariffa (Alarcon-Aguilar et al, 2007), red yeast rice (Fujimoto et al, 2012b), or Spirulina (Fujimoto et al, 2012a).…”

Section: Introductionmentioning

confidence: 99%

Drug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese Mice

et al. 2014

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The prevalence of obesity is rapidly increasing across the world. Physiologic alterations associated with obesity are known to alter enzyme expression and/or activities. As drug-metabolizing and antioxidant enzymes serve as defense system against potentially toxic compounds, their modulation might have serious consequences. In this work, we studied selected antioxidant and drugmetabolizing enzymes (DME) in monosodium glutamate-mouse model of obesity. Specific activities, protein, and mRNA expressions of these enzymes in liver as well as in small intestine were compared in obese male mice and in their lean counterparts. Furthermore, expression of the NF-E2-related factor 2 (Nrf2) and its relation to obesity were tested. Obtained results showed that obesity affects expression and/or activities of some DME and antioxidant enzymes.

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“…Research suggests (Alarcon-Aguilar et al, 2007) the anti-obesity effect of hibiscus tea. In a study conducted by Alarcon-Aguilar and others, administration of hibiscus to MSG mice inhibited body weight gain in mice [34]. Cinnamon was shown to lower liver fat in mice administered the spice [35].…”

Section: Discussionmentioning

confidence: 93%

Chemopreventive Potential of Select Herbal Teas and Spices on Azoxymethane-Induced Aberrant Crypt Foci in Fisher 344 Male Rats

Willis¹,

Sunkara²,

Willis³

et al. 2017

FNS

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Colon cancer is the third leading cause of death in the US. Selected herbal teas and spices may reduce incidence of chronic diseases, including cancer. The objective of this study was to identify the effect of strawberry leaf, raspberry leaf, hibiscus teas and cinnamon on azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats. After acclimatization period (1 wk), 49 male weanling rats were divided into 16 groups. Control (CON) group fed AIN-93G diet; 15 treatment groups were administered control diet + strawberry leaf tea (STW), raspberry leaf tea (RAS), hibiscus tea (HIB), cinnamon (CIN), strawberry leaf tea + cinnamon (STW + CIN), raspberry leaf tea + cinnamon, (RAS + CIN), hibiscus tea + cinnamon (HIB + CIN), and strawberry leaf tea + raspberry leaf tea + hibiscus tea + cinnamon in combination (COM) at 2 levels each (teas added at 1% and 2%; CIN added at 2.5% and 5%). Rats received 24 mg/kg body weight AOM in saline s/c at 7 and 8 weeks of age. Animals received experimental diets until sacrificed by CO 2 asphyxiation (17 weeks of age). ACF were enumerated in colons. Hepatic antioxidant enzymes were determined; superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and glutathione (GH). Treatment groups had reduction in ACF compared to CON (154). Lowest ACF observed in HIB 2% + CIN 5% (13.16) with 91.45% reduction compared to CON. ACF observed in treatment groups administered teas and cinnamon combinations were lower than those administered teas singly. SOD and CAT activities in rats administered treatment diets were higher than CON (13.63 U/mL, 0.95 umol·min). Rats administered COM (20.65 U/mL) had highest SOD activity. CAT activity was 51.27% higher in rats administered HIB 2% (1.96 umol·min −l ·ml −1 ). GPX activity ranged from 7.26 (STW 1% + CIN 2.5%) to 9.59 (STW 2%) umol·min −l ·ml −1. Results suggest that herbal teas and spices may reduce the risk of colon cancer and improve antioxidant status; regular consumption How to cite this paper:

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Effect of Hibiscus sabdariffa on obesity in MSG mice

Cited by 150 publications

References 25 publications

Mechanism of delayed puberty in rats whose mothers consumedHibiscus sabdariffaduring lactation

Mechanism of delayed puberty in rats whose mothers consumedHibiscus sabdariffaduring lactation

Drug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese Mice

Chemopreventive Potential of Select Herbal Teas and Spices on Azoxymethane-Induced Aberrant Crypt Foci in Fisher 344 Male Rats

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