Effect of high fat diet and excessive compressive mechanical force on pathologic changes of temporomandibular joint

Du, Jing; Jiang, Qian; Li, Mei; Ren, Yang; Wen, Juan; Lin, Shupeng; Huang, Li

doi:10.1038/s41598-020-74326-z

Cited by 17 publications

(16 citation statements)

References 38 publications

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“…Logistic regression analysis showed no significant association between BMI and the presence of OA, and it suggested that the rs8044769 variant is significantly associated with TMJOA. However, results of an in vivo mouse model suggested that the development of pathological changes in TMJ could be caused by the excessive compressive mechanical force and high-fat diet-induced obesity [ 29 ]. In addition, it has been reported that a quick eating rate is positively associated with excess body weight [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Involvement of an FTO gene polymorphism in the temporomandibular joint osteoarthritis

et al. 2021

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Objectives The FTO gene has been reported as an obesity-associated gene and is also considered a risk gene for osteoarthritis (OA). However, its exact function is unclear, and there is conflicting evidence on the involvement of FTO polymorphisms in OA via obesity. The purpose of this study was to determine the effects of FTO polymorphism rs8044769 alleles on OA in the temporomandibular joint (TMJ), which is minimally affected by body weight. Materials and methods A total of 324 TMJs (113 with OA and 211 without OA, serving as controls) from 162 Japanese patients with temporomandibular disorders and undergoing MRI examination were analyzed. Genotyping was conducted, and multivariate analysis was performed after adjusting for the effects of age, sex, body mass index, and TMJ disc abnormalities. Results Mean age, BMI, and sex did not differ between the TMJs with OA and the TMJs without OA, but a significant difference was found for positional and dynamic disc abnormalities (P < 0.05). The allele frequency of FTO polymorphisms also differed significantly between the TMJs with OA and the TMJs without OA (P = 0.011). Moreover, logistic regression analysis showed no significant association between BMI (P = 0.581) and the occurrence of TMJOA but also indicated that the CC allele of rs8044769 is a risk factor for TMJOA (P = 0.040). Conclusions Our results show that rs8044769 in the FTO gene might be involved in TMJOA. Clinical relevance The present study provides a basis for a deeper understanding of the mechanism underlying degenerative skeletal diseases and the more effective selection and development of treatment strategies based on the patients’ genetic characteristics.

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Section: Discussionmentioning

confidence: 99%

Involvement of an FTO gene polymorphism in the temporomandibular joint osteoarthritis

et al. 2021

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“…The association of osteoarthritis histological severity and lipid accumulation in cartilage was reported [32][33][34]. In a TMJ OA study, the degeneration of the joint was associated with mechanical overload and high-fat diet [35].…”

Section: ) Obesity and Adipose Tissuementioning

confidence: 96%

Pathophysiology of Temporomandibular Joint Arthritis: Review

Kim

Jeong

et al. 2021

JOMP

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As for temporomandibular joint arthritis (TMJ OA), managing the contributing factors at an early stage through accurate diagnosis is necessary to prevent irreversible bone changes. TMJ OA, which is a multi-organ disease caused by various pathophysiological mechanisms, is developed mainly due to mechanical overload. It is a disease characterized by degeneration of articular cartilage and subchondral bone as a low-level inflammatory arthritis condition developed by dysregulation of catabolic and anabolic activity of chondrocytes. Age, mechanical overload sensing of cartilage, chondrocyte apoptosis, catabolic enzymes, inflammatory factors, abnormal remodeling of subchondral bone, and estrogens may be involved in the pathogenesis of arthritis. Therefore, a comprehensive evaluation is needed to diagnose and manage progressive cartilage degeneration, subchondral bone remodeling, and associated symptoms of TMJ OA.

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“… Griffin et al (2010) first observed loss of proteoglycans in the TMJ of C57BL/6J mice with a high-fat diet (45% kcal fat) for 45 weeks. Du et al (2020) studied the effect of high-fat diet (60% kcal fat) on TMJ of C57BL/6 mice. Less cartilage matrix, thinner condylar cartilage, and vertical clefts were observed in overweight mice after 12 weeks of high-fat feeding.…”

Section: Classification Of Animal Models In Temporomandibular Joint O...mentioning

confidence: 99%

Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection

Zhao

Zhou

et al. 2022

Front. Physiol.

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Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease that can cause severe pain and dysfunction. It has a serious impact on the quality of lives of patients. Since mechanism underlying the pathogenesis of TMJOA is not fully understood, the development of effective tools for early diagnosis and disease-modifying therapies has been hindered. Animal models play a key role in understanding the pathological process of diseases and evaluating new therapeutic interventions. Although some similarities in disease processes between animals and humans are known, no one animal model is sufficient for studying all characteristics of TMJOA, as each model has different translatability to human clinical conditions. For the past 4 decades, TMJOA animal models have been studied by numerous researchers and can be broadly divided into induced, naturally occurring, and genetically modified models. The induced models can be divided into invasive models (intra-articular injection and surgical induction) or non-invasive models (mechanical loading, high-fat diet, and sleep deprivation). Different types of animal models simulate different pathological expressions of TMJOA and have their unique characteristics. Currently, mice, rats, and rabbits are commonly used in the study of TMJOA. This review sought to provide a general description of current experimental models of TMJOA and assist researchers in selecting the most appropriate models for different kinds of research.

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Effect of high fat diet and excessive compressive mechanical force on pathologic changes of temporomandibular joint

Cited by 17 publications

References 38 publications

Involvement of an FTO gene polymorphism in the temporomandibular joint osteoarthritis

Involvement of an FTO gene polymorphism in the temporomandibular joint osteoarthritis

Pathophysiology of Temporomandibular Joint Arthritis: Review

Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection

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