Effect of high‐flow nasal oxygen on postoperative oxygenation in obese patients: A randomized controlled trial

Rosén, Jacob; Frykholm, Peter; Fors, Diddi

doi:10.1002/hsr2.616

Cited by 5 publications

(8 citation statements)

References 34 publications

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“…Second, after reviewing full texts in accordance with the inclusion criteria, 3 records were trial protocols, and 3 records did not include our outcomes. Finally, 12 trials were included in our meta-analysis [12][13][14][15][16][17][18][19][20][21][22][23].…”

Section: Trial Selectionmentioning

confidence: 99%

“…ese included 12 trials were published from 2015 to 2022, and the population sizes ranged from 40 to 155, with a total of 798 patients. Our meta-analysis included the cardiothoracic surgery [12,13], bariatric surgery [14,16,[18][19][20][21][22][23], colonoscopy [15], and elective surgery [17]. e interventional time point was varied among included trials.…”

Section: Trial Characteristicsmentioning

confidence: 99%

“…e oxygen ow of HFNC ranged from 25 to 120 L/min, and in the COT group, the oxygen was delivered through facemask or nasal cannula (2∼15 L/min). Eight trials provided the incidence of hypoxemia [14,15,[18][19][20][21][22][23]. While three trials used the de nition of SpO 2 < 90% [15,19,21], four trials used the de nition of SpO 2 < 92% [14,18,22,23], and one trial used the de nition SpO 2 < 95% [20].…”

Section: Trial Characteristicsmentioning

confidence: 99%

“…Eight trials provided the incidence of hypoxemia [14,15,[18][19][20][21][22][23]. While three trials used the de nition of SpO 2 < 90% [15,19,21], four trials used the de nition of SpO 2 < 92% [14,18,22,23], and one trial used the de nition SpO 2 < 95% [20]. e risks of bias of individual trials are summarized in Figures 2 and 3.…”

Section: Trial Characteristicsmentioning

confidence: 99%

“…Considering the impossibility of blinding among patients and medical sta , performance bias was high in all studies. In addition to the performance bias, eight trials were categorized as being at low risk of bias [12,14,15,[18][19][20][21]23], and four trials as being unclear [13,16,17,22].…”

Section: Trial Characteristicsmentioning

confidence: 99%

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Efficacy of High-Flow Nasal Cannula versus Conventional Oxygen Therapy in Obese Patients during the Perioperative Period: A Systematic Review and Meta-Analysis

Zhou

Wang

2022

Canadian Respiratory Journal

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Background. Obesity is a risk factor for severe airway obstruction and hypoxemia. High-flow nasal cannula (HFNC) is considered as a novel method for oxygen therapy, but the efficacy of HFNC for obese patients is controversial. This meta-analysis aimed to assess the efficacy of HFNC compared with conventional oxygen therapy (COT) in obese patients during the perioperative period. Methods. We searched the PubMed, Embase, Web of Science, the Cochrane Library, and Google scholar databases for randomized controlled trials (RCTs) that compared the efficacy of HFNC with COT in obese patients during the perioperative period. The primary outcome was the incidence of hypoxemia, while the secondary outcomes included the lowest SpO2, the need for additional respiratory support, and the hospital length of stay (LOS). Results. Twelve trials with 798 obese patients during the perioperative period were included. Compared with COT, HFNC reduced the incidence of hypoxemia (RR, 0.60; 95% CI, 0.43 to 0.83; P = 0.002 ; I2 = 24%; 8 RCTs; n = 458), increased the lowest SpO2 (MD, 2.88; 95% CI, 1.53 to 4.22; P < 0.0001 ; I2 = 32%; 5 RCTs; n = 264), decreased the need for additional respiratory support (RR, 0.43; 95% CI, 0.21 to 0.88; P = 0.02 ; I2 = 0%; 3 RCTs; n = 305), and shortened the hospital LOS (MD, −0.31; 95% CI, −0.57 to −0.04; P = 0.02 ; I2 = 0%; 3 RCTs; n = 214). Conclusions. This meta-analysis showed that compared with COT, the use of HFNC was able to reduce the incidence of hypoxemia, increase the lowest SpO2, decrease the need for additional respiratory support, and shorten the hospital LOS in obese patients during the perioperative period. Well-organized trials with large sample size should be conducted to support our findings.

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