Effect of highly active antiretroviral therapy on cervicovaginal HIV-1 RNA

Abstract

The cervicovaginal HIV-1 RNA level was positively correlated with plasma HIV-1 RNA and negatively with the CD4 cell count. The use of HAART was significantly associated with below-detectable levels of HIV-1 RNA in both plasma and the genital tract. HIV-1 RNA suppression in the genital tract may occur rapidly after initiating therapy.

ART influences HIV persistence in the female reproductive tract and cervicovaginal secretions

“…As seen in humans, there was an overall significant positive linear correlation between the viral load in plasma and CVS (Spearman's correlation coefficient = 0.55 [95% CI, 0.36-0.69, P < 0.001, n = 51]) (Figure 3E and refs. 31,(39)(40)(41)(42).…”

Knowledge, attitude and practice towards HIV post-exposure prophylaxis of health professionals of Gimbi town in Ethiopia: a cross-sectional study

“…[2][3][4][5] This is evidenced by data obtained from animal's studies 6,7 and a case control study of post exposure prophylaxis following needle stick injury in health care settings. 8 According to the centers for diseases control and prevention (CDC), individuals who took zidovudine monotherapy following occupational exposure were less likely to acquire HIV as compared to those who did not take medication.…”

The impact of highly active antiretroviral therapy on high-risk behaviour of HIV-infected patients in sub-Saharan Africa

“…In a study conducted in the United States to evaluate the time course and magnitude of decay in cervical and vaginal HIV-1 shedding as women initiate HAART [30], genital HIV-1 shedding decreased rapidly after HAART initiation, which is consistent with a rapid decrease in infectivity. In a study from Kenya assessing the effect of acquisition and treatment of cervical infection on genital HIV shedding in women on HAART [31], most cervical HIV-1 RNA concentrations were near the threshold for detection, which suggested that HIV infectivity remains low, and thus HAART reduces genital HIV-1 shedding. Another study [32] found a positive correlation between HIV-1 RNA levels and plasma HIV-1 RNA and a negative correlation with the CD4 cell count.…”