Effect of HIV and malaria parasites co-infection on immune-hematological profiles among patients attending anti-retroviral treatment (ART) clinic in Infectious Disease Hospital Kano, Nigeria

Jegede, Feyisayo Ebenezer; Oyeyi, T. I.; Abdulrahman, Surajudeen Abiola; Mbah, Henry A.; Badru, Titilope; Agbakwuru, Chinedu; Adedokun, Oluwasanmi

doi:10.1371/journal.pone.0174233

Cited by 65 publications

(59 citation statements)

References 36 publications

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“…In this study, the prevalence of the co-infection does not differ significantly between males and females and is not associated with age. This agrees with findings from a study in Kano, North-West Nigeria(24) but contrary to another one from Jos North-Central Nigeria(19). This could be explained by the fact that the study conducted in Jos was among subjects that were mainly urban residents unlike that of the present study which comprises both urban and rural dwellers.…”

Section: Discussionsupporting

confidence: 91%

HIV-malaria co-infection and its determinants among patients attending antiretroviral treatment clinic in Zaria, North-Western Nigeria

Gumel

Aliyu

Olayinka

et al. 2019

Preprint

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IntroductionMalaria and HIV are two important global public health problems. Together, they cause more than two million deaths each year. In sub-Saharan Africa alone, more than 29 million people are living with HIV/AIDS and about 70% of population is at risk to malaria infection. Nigeria accounts for about a quarter of the global malaria cases and tenth of the global HIV cases. Recent theories suggested possibilities of high occurrence of HIV-malaria co-infection wherever there is geographical overlap of the two diseases. We therefore conducted this study to determine the prevalence of HIV-malaria co-infection and its determinants in a malaria endemic setting.MethodsWe conducted a cross-sectional study. Two hundred and sixty-two clients attending antiretroviral treatment (ART) clinic in Zaria, Kaduna State were enrolled between February and April 2018 using systematic sampling technique. Questionnaires were administered to collect information on respondents’ personal characteristics as well as their knowledge, perception and practices on malaria prevention. Venous blood samples were collected and analyzed for malaria parasite, viral load, CD4, and FBC using Giemsa stained light microscopy, COBAS TaqMan equipment, BD FACS™ flow cytometer, and Sysmex haematology analyser respectively. Descriptive and inferential statistics were performed, predictors of HIV-malaria co-infection were ascertained at multivariate analysis.ResultsMedian age of the respondents was 33 years, 52% were females, 65% were married, 65% were employed, 57% lived in urban residence, and 34% had tertiary education. The prevalence of malaria co-infection among HIV patients was found to be 22.9%. Significant risk factors for the co-infection were high HIV viral load (aOR= 3.30, C.I = 1.15-9.45), being co-infected with TB (aOR= 5.60, C.I = 1.34-23.33), poor knowledge of malaria infection (aOR= 3.12, C.I = 1.27-7.72) and poor practice of malaria prevention (aOR= 13.30, C.I = 4.88-36.23).ConclusionThe level of occurrence of malaria among HIV infected patients in this setting calls for attention. We recommended that health education on malaria should be a priority in malaria control programme; the programmes for control of HIV, malaria and TB should collaborate to ensure integrated service delivery and that people living with HIV/AIDS should be given special consideration for malaria prevention.

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Section: Discussionsupporting

confidence: 91%

HIV-malaria co-infection and its determinants among patients attending antiretroviral treatment clinic in Zaria, North-Western Nigeria

Gumel

Aliyu

Olayinka

et al. 2019

Preprint

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“…Using (11) in the expression for in (10) shows that the nonzero (endemic) equilibria of the model satisfy (12) where, and…”

Section: Existence Of Endemic Equilibrium (Ee)mentioning

confidence: 99%

“…HIV infection is often associated with several comorbidities caused by the presence of malaria [21]. Studies show that co-infection fuels each other and information on co-infection effect on immune system is important for patient care [10,18].…”

Section: Introductionmentioning

confidence: 99%

Impact of Treatment on HIV-Malaria CoInfection Based on Mathematical Modeling

Saha

Niger

Podder

2019

GANIT: J. Bangladesh Math. Soc.

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The distribution of HIV and malaria overlap globally. So there is always a chance of co-infection. In this paper the impact of medication on HIV-Malaria co-infection has been analyzed and we have developed a mathematical model using the idea of the models of Mukandavire, et al. [13] and Barley, et al. [3] where treatment classes are included. The disease-free equilibrium (DFE) of the HIV-only model is globally-asymptotically stable (GAS) when the reproduction number is less than one. But it is shown that in the malaria-only model, there is a coexistence of stable disease-free equilibrium and stable endemic equilibrium, for a certain interval of the reproduction number less than unity. This indicates the existence of backward bifurcation. Numerical simulations of the full model are performed to determine the impact of treatment strategies. It is shown that malaria-only treatment strategy reduces more new cases of the mixed infection than the HIV-only treatment strategy. Moreover, mixed treatment strategy reduces the least number of new cases compared to single treatment strategies. GANIT J. Bangladesh Math. Soc.Vol. 39 (2019) 45-62

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“…Similarly, a significant association has been documented between CD4 T-cell count less than 200, and a high risk of anaemia in HIV-malaria co-infected patients. P. falciparum malaria is associated with the majority of malaria cases among HIV positive individuals (Jegede et al, 2017).…”

Section: Prevalence Of Hiv and Malaria Co-infection In Nigeriamentioning

confidence: 99%

Prevalence of Human Immunodeficiency Virus and Malaria Co-Infection in Nigeria: A Review of Published Literature

Alaofin¹,

Naidoo²

2019

GJHS

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Background: Human immunodeficiency virus and malaria are significant global health challenges. Both diseases contribute to the global burden of disease and poverty notable amongst low-income countries, including sub-Sahara Africa and Nigeria. There are little or no available review articles on the prevailing epidemiological data on human immunodeficiency virus and malaria interaction in Nigeria. Aim: This literature review aims to update knowledge on human immunodeficiency virus and malaria co-infection and determine the prevalence of human immunodeficiency virus and malaria from published literature. Method: This work reviewed published articles on human immunodeficiency virus/malaria co-infection published in English in PubMed, Google Scholar, and ScienceDirect. An internet search on Google Scholar was also conducted for studies that were conducted between 2007 and 2017 in Nigeria. Result: The literature review indicated that the highest prevalence of human immunodeficiency virus and malaria co-infection in Nigeria is 86.2%. The mean ± SD among the HIV-malaria co-infected group and the negative malaria group in all of Nigeria’s geo-political zones are 36.6 ± 25.5 and 19.5 ± 15.3, respectively. The highest mean prevalence of 64.5% was reported in human immunodeficiency virus patients co-infected with malaria in the northwest zone. The use of highly active antiretroviral therapy is also associated with a reduced mean positive prevalence of 31.26%. Conclusion: Human immunodeficiency virus-positive individuals across all the geopolitical zones in Nigeria are at high risk of malaria. Findings from this review of literature will provide additional information on HIV-malaria co-infection prevalence and guide public health prevention, control and management practice.

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Effect of HIV and malaria parasites co-infection on immune-hematological profiles among patients attending anti-retroviral treatment (ART) clinic in Infectious Disease Hospital Kano, Nigeria

Cited by 65 publications

References 36 publications

HIV-malaria co-infection and its determinants among patients attending antiretroviral treatment clinic in Zaria, North-Western Nigeria

HIV-malaria co-infection and its determinants among patients attending antiretroviral treatment clinic in Zaria, North-Western Nigeria

Impact of Treatment on HIV-Malaria CoInfection Based on Mathematical Modeling

Prevalence of Human Immunodeficiency Virus and Malaria Co-Infection in Nigeria: A Review of Published Literature

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