Effect of Homocysteine Concentration in Early Pregnancy on Gestational Hypertensive Disorders and Other Pregnancy Outcomes

Dodds, Linda; Fell, Deshayne B.; Dooley, Kent C.; Armson, B. Anthony; Allen, Alexander C.; Nassar, B.A.; Perkins, Sherry L.; Joseph, K. S.

doi:10.1373/clinchem.2007.097469

Cited by 103 publications

(92 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some studies showed that hyperhomocysteinemia in early pregnancy can increase the risk of developing of preeclampsia 7,16,17 . In contrast, other studies detected no differences in midtrimester maternal circulating level of homocysteine between women who developed preeclampsia and normal pregnant women 15,[18][19][20] .…”

Section: Discussionmentioning

confidence: 99%

Circulating levels of homocysteine in preeclamptic women

Khosrowbeygi

Ahmadvand

2011

Bangladesh Med Res Counc Bull

View full text Add to dashboard Cite

It has been hypothesized that maternal hyperhomocysteinemia to be associated with preeclampsia. The aims of the present study were to examine maternal serum levels of total homocysteine in preeclamptic women and its association with the severity of the disease. The study population consisted of 30 preeclamptic patients and 30 matched healthy pregnant women. Serum levels of total homocysteine were assessed using enzyme immunoassay method. Maternal serum levels of total homocysteine were significantly higher in preeclamptic group than in normal pregnant women. Women with severe preeclampsia had higher serum levels of total homocysteine than mild preeclamptic patients. Levels of total homocysteine correlated positively with systolic blood pressure values in preeclamptic women. In summary, maternal serum levels of total homocysteine were increased in preeclamptic women and hyperhomocysteinemia was associated with severity of preeclampsia.

show abstract

Section: Discussionmentioning

confidence: 99%

Circulating levels of homocysteine in preeclamptic women

Khosrowbeygi

Ahmadvand

2011

Bangladesh Med Res Counc Bull

View full text Add to dashboard Cite

show abstract

“…24 Gestational age was confirmed using last menstrual period or ultrasound estimates. Blood samples were collected from October 2002 …”

Section: Cohort Design Participant Recruitment and Blood Collectionmentioning

confidence: 99%

Vitamin D status in early pregnancy and risk of preeclampsia

Achkar¹,

Dodds²,

Giguère³

et al. 2015

American Journal of Obstetrics and Gynecology

Self Cite

108

View full text Add to dashboard Cite

OBJECTIVE-We sought to examine the association between maternal serum 25-hydroxyvitamin D (25[OH]D) concentration in early pregnancy and the subsequent diagnosis of preeclampsia (PE).STUDY DESIGN-This was a nested case-control study from 2 prospective Canadian cohorts conducted in Quebec City, Quebec, and Halifax, Nova Scotia, from 2002 through 2010. Participants were pregnant women (n=169 cases with PE and 1975 controls). Maternal serum was drawn <20 weeks of gestation, and 25(OH)D measurement was performed. Cases were ascertained from medical records. Logistic regression analysis was used to estimate adjusted odds ratios with 95% confidence intervals.RESULTS-Women who developed PE had a significantly lower 25(OH)D concentration at a mean gestational age of 14 weeks compared with women in the control group (mean ± SD 25[OH]D 47.2 ± 17.7 vs 52.3 ± 17.2 nmol/L, P < .0001). Women with 25(OH)D <30 nmol/L compared to those with at least 50 nmol/L had a greater risk of developing PE (adjusted odds ratio, 2.23; 95% confidence interval, 1.29-3.83) after adjustment for prepregnancy body mass index, maternal age, smoking, parity, season and year of blood collection, gestational week at blood collection, and cohort site. Exploratory analysis with cubic splines demonstrated a dose-response relationship between maternal 25(OH)D and risk of PE, up to levels around 50 nmol/L, where the association appeared to plateau. Canada, Feb. 12-15, 2014; and CONCLUSION-Maternal CIHR Author Manuscript CIHR Author ManuscriptCIHR Author Manuscript women of child-bearing age should be explored as a strategy for reducing PE and for promoting a healthier pregnancy. Keywords 25-hydroxyvitamin D; preeclampsia; vitamin DOne of the United Nations' Millennium Development Goals for maternal health is to reduce maternal mortality by three-quarters by 2015. 1 Hypertensive disorders of pregnancy, including preeclampsia (PE), are among the leading causes of maternal morbidity and mortality. 2 The clinical manifestations of PE are well described as elevated blood pressure and protein-uria, 3 yet the etiology and prevention of the syndrome remain unclear.Strategies to prevent PE include anti-platelet action of low-dose aspirin 4 Several epidemiologic studies have explored the association between vitamin D status and PE. In 2 of these studies, serum concentrations of 25(OH)D and 1,25-hydroxyvitamin D in early pregnancy were lower in women who subsequently developed PE. 13,16 Overall, however, the epidemiological evidence is conflicting and previous studies are limited by small sample sizes or the absence of adjustment for relevant confounders, such as season, smoking, or parity. 13,[16][17][18][19][20][21][22] Moreover, there is a lack of consensus about the threshold of 25(OH)D at which the risk of PE is decreased. Given a strong biological rationale for a link between vitamin D metabolism and the physiopathology of PE through immunomodulation 16 and angiogenesis, 23 stronger epidemiologic evidence from studies with larger sample sizes and ...

show abstract

“…Its alleles with C677/T677 or alanine 222 to valine substitutions are highly represented in the Caucasian population (Frosst et al 1995). This mutation is associated with thermolability and lower catalytic activity of MTHFR, elevated Hcy, and increased risk of obstetrical pathologies (De Franchis et al 1995, Shields et al 1999, Van der Put et al 2001, Dodds et al 2008. Regarding Hcy in pregnancy, numerous questions and problems remain unanswered such as the specific input of each organ or different stages of the folate-related metabolism into the integral value of Hcy concentrations in plasma and the particular role of the placenta in the overall folate-related metabolism in mother and fetus.…”

Section: Introductionmentioning

confidence: 99%

Placental markers of folate-related metabolism in preeclampsia

Mislanova¹,

Martsenyuk²,

Huppertz³

et al. 2011

Reproduction

View full text Add to dashboard Cite

The etiology and degree of clinical symptoms of preeclampsia depend on genotypic and phenotypic maternal and trophoblast factors, and elevated levels of plasma homocysteine (Hcy) are one of the pathogenetic factors of preeclampsia. To assess the impact of the folate-related metabolism, we characterized the indices of this metabolism in 40 samples from uncomplicated term placentas and 28 samples from preeclamptic pregnancies by quantifying the total content of folate, methionine (Met), Hcy and related cysteine, and glutathione (GSH) in compliance with the 677 C/T genotype of methylene tetrahydrofolate reductase (MTHFR). The prevalence of MTHFR genotypes was not significantly different between the two groups. The polymorphism of MTHFR was not unambiguously connected with the content of total placental Met, Hcy and related cysteine, and GSH either in uncomplicated or in complicated pregnancies. By contrast, the combination of the heterozygous MTHFR genotype with folate deficiency in the samples from preeclamptic pregnancies was characterized by a statistically significant decrease in the Met content, a trend toward increased Hcy levels and a tight association between metabolically directly and indirectly related compounds, e.g. positive relation between Hcy versus cysteine and folate versus GSH and negative relation between folate versus Hcy and both Hcy and cysteine versus GSH. We demonstrated the expression of cystathionine-b-synthase (CBS) in human placenta at term by RT-PCR and western blot analysis, for the first time, and confirmed its catalytic activity and the accumulation of cysteine and CBS in placental explants cultivated in the presence of elevated Hcy concentrations. We suggest that disturbance in placental folate-related metabolism may be one of the pathogenetic factors in preeclampsia.

show abstract

Effect of Homocysteine Concentration in Early Pregnancy on Gestational Hypertensive Disorders and Other Pregnancy Outcomes

Cited by 103 publications

References 31 publications

Circulating levels of homocysteine in preeclamptic women

Circulating levels of homocysteine in preeclamptic women

Vitamin D status in early pregnancy and risk of preeclampsia

Placental markers of folate-related metabolism in preeclampsia

Contact Info

Product

Resources

About