Effect of honey on bacterial translocation and intestinal morphology in obstructive jaundice

Gencay, Cem; Kılıçoğlu, Sibel Serin; Kısmet, Kemal; Kilicoglu, Bulent; Erel, Serap; Muratoglu, Sabahattin; Sunay, Asli Elif; Erdemlı, Esra; Akkuş, Mehmet Ali

doi:10.3748/wjg.14.3410

Cited by 26 publications

(29 citation statements)

References 26 publications

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“…14 Hence various researchers have assessed villous morphology including villous heights to evaluate the effect of the test drugs in the model of common bile duct ligation. 15,16 In our study, A. marmelos and P. granatum significantly prevented the blunting of villi and maintained the villous heights and the higher doses were comparable to glutamine. The exact mechanism by which A. marmelos and P. granatum prevented the damage to the intestinal mucosa is not known.…”

Section: Discussionmentioning

confidence: 75%

Evaluation of the effects of Aegle marmelos and Punica granatum in an experimental model of gastrointestinal barrier dysfunction

Malhi¹,

Kamat²,

Deogharkar³

et al. 2016

Int J Basic Clin Pharmacol

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Section: Discussionmentioning

confidence: 75%

Evaluation of the effects of Aegle marmelos and Punica granatum in an experimental model of gastrointestinal barrier dysfunction

Malhi¹,

Kamat²,

Deogharkar³

et al. 2016

Int J Basic Clin Pharmacol

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“…Bacteria from homogenized mesenteric lymph nodes, liver, spleen, and portal and peripheral venous blood and detection of endotoxins from portal and peripheral venous blood are the most common examples described in the literature (35) (39) (40) . In our experience, we observed bacterial translocation to mesenteric lymph nodes in the CF group, but no other organ was affected.…”

Section: Discussionmentioning

confidence: 99%

“…A breakdown of the equilibrium of the autochthonous microbial population contributes to the selective overgrowth of some species, which may promote the translocation process (35) (36) . Immunomodulation might explain the alterations in microbial populations that occur during schistosomiasis.…”

Section: Discussionmentioning

confidence: 99%

“…Weaknesses in immunity or damage to the intestinal wall may (either alone or in conjunction) facilitate the passage of bacteria (35) (36) (38) . Chronic schistosomiasis, splenectomy associated with weight reduction and alterations in immune responses and the duodenal mucosa resulting from infection may have contributed to the increase in the intestinal microbiota diversity and the consequent increase in bacterial translocation observed in this study.…”

Section: Discussionmentioning

confidence: 99%

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Post-splenectomy infections in chronic schistosomiasis as a consequence of bacterial translocation

Lima

Negro-Dellacqua

Santos

et al. 2015

Rev. Soc. Bras. Med. Trop.

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Introduction:Bacterial translocation is the invasion of indigenous intestinal bacteria through the gut mucosa to normally sterile tissues and internal organs. Schistosomiasis may cause alterations in the immune system and damage to the intestines, portal system and mesenteric lymph nodes. This study investigated bacterial translocation and alterations in the intestinal microbiota and mucosa in schistosomiasis and splenectomized mice. Methods: Forty female 35-day-old Swiss Webster mice were divided into the following four groups with 10 animals each: schistosomotic (ESF), splenectomized schistosomotic (ESEF), splenectomized (EF) and control (CF). Infection was achieved by introduction of 50 Schistosoma mansoni (SLM) cercariae through the skin. At 125 days after birth, half of the parasitized and unparasitized mice were subjected to splenectomy. Body weights were recorded for one week after splenectomy; then, the mice were euthanized to study bacterial translocation, microbiota composition and intestinal morphometry. Results: We observed signifi cant reductions in the weight increases in the EF, ESF and ESEF groups. There were increases of at least 1,000 CFU of intestinal microbiota bacteria in these groups compared with the CF. The EF, ESF and ESEF mice showed decreases in the heights and areas of villi and the total villus areas (perimeter). We observed frequent co-infections with various bacterial genera. Conclusions: The ESEF mice showed a higher degree of sepsis. This fi nding may be associated with a reduction in the immune response associated with the absence of the spleen and a reduction in nutritional absorption strengthened by both of these factors (Schistosoma infection and splenectomy).

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“…Up to now, some studies which investigate the BT in obstructive jaundice models have been carried out (15)(16)(17)(18)(19)(20)(21)(22). In some of them, different materials were given to the models in whom bile duct was ligated to observe their effects on BT (16)(17)(18)(19)(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Effects on Bacterial Translocation of High-Fat Enteral Nutrition in Bile Duct Ligated Rats

Elipek¹,

Utkan²

2012

Balkan Med J

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Objective: Bacterial Translocation (BT) from the gastrointestinal system is at the center of current sepsis theories. In patients with obstructive jaundice, the absence of intraluminal bile flow causes some alterations and mucosal damage in the gut. In the present study, it was aimed to investigate the effects on BT of high-fat enteral nutrition in bile duct ligated rats. Material and Methods:In this study, a total of 28 healthy Spraque-Dawley rats, weighing 230-300 gr, were grouped into four as sham group, control group, high-fat enteral nutrition group and low-fat enteral nutrition group. The rats in all the groups were sacrificed on the seventh postoperative day The values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total and direct bilirubin were measured for biochemical evaluation. Also, samples were taken from the blood, lung, liver, spleen and mesenteric lymph nodes for microbiological evaluation. The results were calculated as CFU/gr and evaluated statistically.Results: In all bile duct ligated rats, all findings of obstructive jaundice were observed clinically (in postoperatively third day) and in the laboratory. It was determined that the lymphatic system is an essential pathway for BT, as reported by similar studies. However, it was observed in this study that the high-fat enteral nutrition may be not severely effective in reducing BT in bile duct ligated rats. The results were supported by statistical analyses. Conclusion:It was observed that high-fat enteral nutrition has no meaningful effects on reducing BT in bile duct ligated rats.

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Effect of honey on bacterial translocation and intestinal morphology in obstructive jaundice

Abstract: Abstract

Cited by 26 publications

References 26 publications

Evaluation of the effects of Aegle marmelos and Punica granatum in an experimental model of gastrointestinal barrier dysfunction

Evaluation of the effects of Aegle marmelos and Punica granatum in an experimental model of gastrointestinal barrier dysfunction

Post-splenectomy infections in chronic schistosomiasis as a consequence of bacterial translocation

Effects on Bacterial Translocation of High-Fat Enteral Nutrition in Bile Duct Ligated Rats

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