CANTÜ RK, ZEYNEP, NUH ZAFER CANTÜ RK, BERRIN Ç ETINARSLAN, NIHAT ZAFER UTKAN, AND ILHAN TARKUN. Nosocomial infections and obesity in surgical patients. Obes Res. 2003;11:769-775. Objective: There is an increased morbidity and mortality associated with surgery in the obese patient. This study was conducted to determine risk factors and compare the nosocomial infection rate in obese and nonobese surgical patients.
Research Methods and Procedures:A total of 395 surgical patients were evaluated. BMI was calculated for each patient. Various conventional risk factors for nosocomial infections were recorded. Biochemical parameters with plasma total cholesterol and high-density lipoproteincholesterol levels were measured. The diagnosis of infection was made according to the Centers for Disease Control and Prevention criteria. Univariate and two-step multivariate logistic regression methods were used for determination of nosocomial infection risk factors. Results: There were 117 nosocomial infections identified in 96 of 395 surgically operated patients. A significant increase in the total number of nosocomial infections was determined in obese patients compared with the normalweight patients (p Ͻ 0.05). High-density lipoprotein-cholesterol below the 10th percentile increased risk of surgical site infection. Discussion: Our results suggest that obesity is an important risk factor for postoperative nosocomial infection.
Background/Aim: Breast cancer (BC) incidence and mortality rates have been increasing due to the lack of appropriate diagnostic tools for early detection. Proteomicsbased studies may provide novel targets for early diagnosis and efficient treatment. The aim of this study was to investigate the global changes occurring in protein profiles in breast cancer tissues to discover potential diagnostic or prognostic biomarkers. Materials and Methods: BC tissues and their corresponding healthy counterparts were collected, subtyped, and subjected to comparative proteomics analyses using two-dimensional gel electrophoresis (2-DE) and twodimensional electrophoresis fluorescence difference gel (DIGE) coupled to matrix-assisted laser desorption/ ionisation-time of flight mass spectrometry (MALDI-TOF/TOF) to explore BC metabolism at the proteome level. Western blot analysis was used to verify changes occurring at the protein levels. Results: Bioinformatics analyses performed with differentially regulated proteins highlighted the changes occurring in triacylglyceride (TAG) metabolism, and directed our attention to TAG metabolism-associated proteins, namely glycerol-3-phosphate dehydrogenase 1 (GPD1) and monoacylglycerol lipase (MAGL). These proteins were downregulated in tumor groups in comparison to controls.Conclusion: GPD1 and MAGL might be promising tissuebased protein biomarkers with a predictive potential for BC.
Nibrin, encoded by the gene, participates in DNA repair. Mutations in the gene lead to Nijemen breakage syndrome, which may result in several types of diseases, particularly susceptibility to cancer, including breast cancer. Polymorphic variants and defective mutations occurring in the gene increase the risk of breast cancer through the double-stranded break repair mechanism. The aim of the present study was to investigate a possible association between breast cancer and genetic variants, 924 T>C, 8360 G>C and 30537 G>C, in women with breast cancer. Locus-specific primers were designed to study 3 genetic variants in DNA samples isolated from peripheral blood samples of 101 women with breast cancer and 115 healthy controls. Subsequently, 3 polymerase chain reaction-restriction fragment length polymorphism methods were performed and the obtained results were statistically analysed. The gene 924 T>C variant was found to be significantly associated with breast cancer (χ=5.722, P=0.017). There were no statistically significant differences between cases and controls in the gene 8360 G>C variant (χ=1,125, P=0.570) or the gene 30537 G>C variant (χ=4.301, P=0.116). In conclusion, the gene 924 T>C variant may be a genetic risk factor for breast cancer development in women with breast cancer.
Knowledge of bariatric surgery is inadequate in the Kocaeli province, which is one of the most socio-economically developed cities, as well as the leading industrial city in Turkey. More social responsibility projects and more objective elucidating via television and social media are also needed to increase the awareness of bariatric surgery.
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