Solar energy technologies represent a viable alternative to fossil fuels for meeting increasing global energy demands. However, to increase the production of solar technologies in the global energy mix, the cost of production should be as competitive as other sources. This study focuses on the implementation of machine learning for estimating the thermophysical properties of nanofluids for nanofluid-based solar energy technologies as this would make the synthesis of nanofluids cost-effective. The prediction of thermal conductivity has gained a lot of research attention, whereas, the viscosity of nanofluids has less concentration of studies. The accurate prediction of the viscosity of hybrid nanofluids is important in estimating the heat transfer performance of nanofluids as regards their pump power requirements and convective heat transfer coefficient in several applications. The rigor of experimentations of hybrid nanofluids has necessitated the need for developing efficient and robust machine learning models for accurately estimating the viscosity of hybrid nanofluids for solar applications. Several studies were aimed at developing a predictive model for the viscosity of nanofluids; however, these models are limited to specific types of nanofluids. This study is aimed at developing a robust machine learning algorithm for predicting the viscosity of several hybrid nanofluids from reliable experimental data (700 datasets) culled from literature. This study implements a novel optimizable Gaussian process regression (O-GPR), which have not been previously used in this area, and compares the result with other commonly used machine learning algorithms like, Boosted tree regression (BTR), Artificial neural network (ANN), support vector regression (SVR), to accurately predict the viscosity of a wide range of Newtonian-based hybrid nanofluid. The input parameters used in training the machine learning models were temperature (T), volume fraction (VF), the acentric factor of the base fluid (ACF), nanoparticle size (NS), and nanoparticle density (ND). The prediction performance of the machine learning algorithms was tested using statistical metrics and was compared with theoretical models. The O-GPR model showed superior predictive performance with an R 2 of 0.999998 and an MSE of 0.0002552. The study conclusively states that the high accuracy prediction of thermophysical properties of nanofluid using robust machine learning models makes the design of nanofluidbased solar energy technologies more cost-effective.