Effect of hydrocortisone on the elimination of fibrin from the pulmonary vessels in the rat

Diffang, Charles; Saldeen, Tom

doi:10.1016/0049-3848(78)90106-8

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…An elevation of these macromole cules has been suggested to increase platelet aggregability [1,2,4], red blood cell aggregation [7], and plasma oncotic pressure and viscosity [4,6] although some au thors disclaimed the latter findings [22], Thus, the above-mentioned complicated effects of ste roids on plateletes, some parameters of plasma fibrino lytic system and hyperlipidemia seem to be more severe in nephrotic patients who were receiving a high dose of steroids, suggesting that steroids could increase the thrombotic tendency in children with MCNS. In fact, an association of high incidence of thrombosis in nephrotic patients during steroid therapy has been described [I], and an experimental study suggested that steroids could inhibit fibrin elimination from the pulmonary vessels with thrombin-induced intravascular coagulation [23]. From these observations, it is tempting to assume that steroids appear to be an additional thrombogenic risk factor by accerelating thrombocytosis and hyperlipi demia, and by reducing plasma fibrinolytic activity in children with MCNS.…”

Section: Discussionmentioning

confidence: 91%

Effect of Corticosteroids on Some Hemostatic Parameters in Children with Minimal Change Nephrotic Syndrome

Ueda¹

1990

Nephron

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Effect of corticosteroids (steroids) on some hemostatic parameters was serially studied in 23 children with minimal change nephrotic syndrome (MCNS). Increased platelet count, erythrocyte sedimentation rate (ESR), cholesterol, fibrinogen, fibrin(ogen) degradation products (FDP), α2-macroglobulin (α2M), α2-antiplasmin (α2AP) and protein C, and reduced antithrombin III (ATIII) and plasminogen (Plg) were noted in relapse before steroid therapy began. With institution of oral prednisolone, FDP started to fall, and platelet count, cholesterol, α2M, ATIII, Plg, α2AP and protein C started to increase despite unchanged nephrotic state from that before the therapy. In remission induced by prednisolone, platelet count, cholesterol, α2M, ATIII, Plg, α2AP and protein C were still increased, but normalized off therapy. ESR, fibrinogen, FDP, α2M and protein C correlated inversely with serum albumin and directly with cholesterol and urine protein excretion. In contrast, ATIII and Plg correlated directly with serum albumin and inversely with cholesterol and urine protein excretion. A direct correlation was only noted between α2AP and the dose of prednisolone. The data indicate that steroids appear to be a thrombogenic factor by accerelating thrombocytosis and hyperlipidemia, and by reducing plasma fibrinolysis in children with MCNS.

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Section: Discussionmentioning

confidence: 91%

Effect of Corticosteroids on Some Hemostatic Parameters in Children with Minimal Change Nephrotic Syndrome

Ueda¹

1990

Nephron

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“…Glucocorticoids suppress the PAA in several types of cells in vitro [12,13,17,21,23,25,35,37,39], including endothelial cells [9,18]. Also, in vivo, glucocorticoids have been reported to suppress the PAA in the mammary gland of rats [21], in human superficial veins [15] and in rat pulmonary vessels [9], and aorta [31], while in rat ovarian granulosa cells the PAA is not affected by glucocorticoids [34], The blood PAA can be affected by ACTH as well as by glucocorticoids [6, 9, 1 5]; a decreased blood PAA after administration of glucocor ticoids has been shown [9,15]. Thyroxine enhances blood PAA [5], while the results after administration of testosterone are not uniform [1,10,11,38], In this study blood PAA remained unchanged after hypophysec tomy which is in accordance with the find ings of another study [22].…”

Section: Discussionmentioning

confidence: 99%

Effect of Hypophysectomy on the Tissue and Blood Plasminogen Activator Activity in the Rat

Smokovitis¹,

Hattey²,

Binder³

1985

Pathophysiol Haemos Thromb

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The response of the fibrinolytic system to hypophysectomy in the rat was studied. 4 and 6 weeks after hypophysectomy the tissue plasminogen activator activity (PAA) was significantly increased in the intima of the aorta, slightly but significantly increased in the renal medulla, and significantly decreased in the vessels of the testis. No change in the PAA of the caudal vena cava, heart, lung and renal cortex was noted. Also, the tissue plasmin inhibition remained unchanged. No effect on the PAA in plasma euglobulin fractions was observed, whereas F VIII was slightly but not significantly decreased 6 weeks after hypophysectomy.

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Variable response of tissue parameters of the fibrinolytic system to unilateral or bilateral adrenalectomy and unilateral or bilateral adrenal demedullation

Smokovitis

Kokolis

Rekkas

et al. 1991

J Endocrinol Invest

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The effect of unilateral and bilateral adrenalectomy, unilateral and bilateral demedullation or unilateral adrenalectomy/unilateral demedullation on tissue plasminogen activator activity (PAA), plasminogen activator inhibition (PAI) and plasmin inhibition (PI) was studied in the rat. All the above treatments induced an increase of PAA in lungs. Increased PAA was also noted in brain after bilateral adrenalectomy or demedullation, as well as unilateral adrenalectomy/unilateral demedullation. In kidneys the PAA was decreased after bilateral adrenalectomy or demedullation and unilateral adrenalectomy/unilateral demedullation. In aorta only after bilateral adrenalectomy a decreased PAA was induced. In heart and liver no changes in PAA were noted. A decreased PAI expressed against tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA) was found in lungs of all treated rats compared to controls. However, an increased PAI was noted in heart, liver and aorta against t-PA or u-PA after bilateral adrenalectomy and in liver after bilateral demedullation as well as after unilateral adrenalectomy/unilateral demedullation (rats with only one adrenal cortex). A dissociation between anti-t-PA and anti-u-PA response was seen in heart, liver and aorta. A variable change in PI was induced in kidneys, aorta, lungs and brain in all treatments except unilateral demedullation or unilateral adrenalectomy. Therefore, the effect of adrenalectomy or demedullation on tissue PAA, PAI and PI was variable and dependent on the extent of the treatment (unilateral or bilateral), the organ as well as the time after the treatment.

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Effect of hydrocortisone on the elimination of fibrin from the pulmonary vessels in the rat

Cited by 7 publications

References 17 publications

Effect of Corticosteroids on Some Hemostatic Parameters in Children with Minimal Change Nephrotic Syndrome

Effect of Corticosteroids on Some Hemostatic Parameters in Children with Minimal Change Nephrotic Syndrome

Effect of Hypophysectomy on the Tissue and Blood Plasminogen Activator Activity in the Rat

Variable response of tissue parameters of the fibrinolytic system to unilateral or bilateral adrenalectomy and unilateral or bilateral adrenal demedullation

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