Effect of Hydrogen‐Rich Water on Oxidative Stress, Liver Function, and Viral Load in Patients with Chronic Hepatitis B

Abstract

Objective : To investigate effects of hydrogen-rich water (HRW) on oxidative stress, liver function and HBV DNA in patients with chronic hepatitis B (CHB). Methods : Sixty patients with CHB were randomly assigned into routine treatment group or hydrogen treatment group in which patients received routine treatment alone or additional oral HRW (1200-1800 mL/day, twice daily), respectively, for 6 consecutive weeks. Serum oxidative stress, liver function, and HBV DNA level were detected before and after treatment. Thirty healthy subjects served as controls.Results : When compared with controls, oxidative stress was obvious in CHB patients, and the liver function also signifi cantly impaired. After treatment, the oxidative stress remained unchanged in routine treatment group, but markedly improved in hydrogen treatment group. The liver function was improved signifi cantly and the HBV DNA reduced markedly after corresponding treatments. Although a signifi cant difference was noted in the oxidative stress between two groups after treatment, the liver function and HBV DNA level were comparable after treatment and both had improved tendencies. Conclusion : HRW signifi cantly attenuates oxidative stress in CHB patients, but further study with long-term treatment is required to confi rm the effect of HRW on liver function and HBV DNA level. Clin Trans Sci 2013; Volume 6: 372-375

Hepatitis B and its Relationship With Oxidative Stress

“…Table 3 shows several studies on the effect of some antioxidant therapies in patients with hepatitis B (94-102). …”

Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells

“…A C C E P T E D ACCEPTED MANUSCRIPT 17 incubation of cells with Aβ, and this inhibition was prevented by HRW co-treatment.…”

“…Moreover, some studies reported HRW can significantly reduce several neurodegenerative diseases and this is associated with increased defense to oxidative stress [16]. Recently, clinical trials have also proven the benefits of HRW in attenuating oxidative stress and inflammation in patients [17,18]. Particularly, oral intake of HRW displays anti-neurotoxicity effects by regulating the oxidant and antioxidant status of rats [19].…”

Influence of redox potential of different water quality on the human blood

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