Effect of Hydrophilic and Hydrophobic Nanoparticles on the Surface Pressure Response of DPPC Monolayers

Guzmán, Eduardo; Liggieri, Libero; Santini, Eva; Ferrari, Michele; Ravera, Francesca

doi:10.1021/jp207713x

Cited by 112 publications

(130 citation statements)

References 47 publications

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“…Recent studies have focused on the toxicology of SiO 2 NPs and have found that SiO 2 NPs can cause harmful biological responses in diverse organs. [4][5][6][7][8][9] The liver, as the major organ for the biotransformation of toxins, is a primary target organ for nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Kupffer cell-mediated hepatic injury induced by silica nanoparticles in vitro and in vivo

Chen¹,

Yang²,

Sun³

2013

IJN

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Silica nanoparticles (SiO 2 NPs) have been shown to exert cytotoxic effects in hepatocytes and to cause liver injury. In the liver, Kupffer cells (KCs), as the resident macrophages, play an important role in the normal physiology and homeostasis of the liver. Nevertheless, few studies have attempted to clarify the role of KCs in hepatic injury induced by SiO 2 NPs. In this study, we treated Buffalo rat liver (BRL) cells with the supernatants of SiO 2 NP-stimulated KCs to determine KC-mediated hepatotoxicity and its underlying preliminary mechanism. We also examined the response of KCs and liver injury in vivo after the administration of SiO 2 NPs. The results showed that KCs stimulated by SiO 2 NPs release large amounts of reactive oxygen species, tumor necrosis factor-α and nitric oxide. After BRL cells were cultured with the supernatants of SiO 2 NP-stimulated KCs, the viability of BRL cells was reduced, and increases in aspartate aminotransferase and lactate dehydrogenase leakage were observed. Exposure to SiO 2 NPs in vivo caused KC hyperplasia, hepatic inflammation, and oxidative stress, which led to changes in the biochemical composition of the liver. These data suggest that SiO 2 NPs activate KCs to mediate hepatic injury and that the preliminary mechanism involves the release of bioactive substances from KCs.

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Section: Introductionmentioning

confidence: 99%

Kupffer cell-mediated hepatic injury induced by silica nanoparticles in vitro and in vivo

Chen¹,

Yang²,

Sun³

2013

IJN

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“…7 Although silica is generally considered to be noncytotoxic, 8 designing silica as nanomaterials may change its biocompatibility because of changes in its physicochemical properties, and its use for biomedical devices should be verified. 7,9,10 A previous study of the biocompatibility of MPS has investigated the general effects of nanomaterials such as size, surface charge, concentration, and morphology. 11 However, the largest expected influence on the difference in biocompatibility between MPS and Col NPs is the pore structure property.…”

Section: Introductionmentioning

confidence: 99%

The comparative immunotoxicity of mesoporous silica nanoparticles and colloidal silica nanoparticles in mice

Lee¹,

Kim²,

Lee³

et al. 2013

IJN

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Background: Mesoporous silica (MPS) nanoparticles (NPs), which have a unique pore structure and extremely large surface area and pore volume, have received much attention because of their biomedical application potential. Using MPS NPs for biomedical devices requires the verification of their biocompatibility because the surface area of NPs is one of the most important determinants of toxicity, including the cellular uptake and immune response. We have previously reported that the cytotoxicity and inflammation potential of MPS NPs have been shown to be lower than those of general amorphous colloidal silica (Col) NPs in macrophages, but the low cytotoxicity does not guarantee high biocompatibility in vivo. In this study, we compared the in vivo immunotoxicity of MPS and Col NPs in the mouse model to define the effects of pore structural conditions of silica NPs. Materials and methods: Both MPS and Col NPs (2, 20, and 50 mg/kg/day) were intraperitoneally administered in female BALB/c mice for 4 weeks, and clinical toxicity, lymphocyte population, serum IgG/IgM levels, and histological changes were examined. Conclusion:The results indicate that in vivo exposure to MPS NPs caused more damage to systemic immunity than that of Col NPs through the dysregulation of the spleen. The results for in vivo data are inconsistent with those for in vitro data, which show lower cytotoxicity for MPS NPs. These results suggest the importance of verifying biocompatibility both in vitro and in vivo during the design of new nanomaterials.

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“…Further understanding of the interaction of NP with the PS have been obtained by the investigation of deposited mixed lipid-NP layers at the aqueous surface. Such surface science approach, utilizing a set of different techniques (Langmuir trough, surface rheology, AFM, Brewster Angle microscopy, ellipsometry), allowed significant effects of the NPs on the structural and dynamic features of model PS to be identified [12,13], such as, modifications of the linearity (see Fig. 1) of its surface tension response under surface area expansion-compression cycles and of the 2-D phase behavior, which are potentially relevant for the impairment of the lung functionality.…”

Section: Interactions Of Inhaled Droplets and Particles With Human Brmentioning

confidence: 99%

Smart and green interfaces: From single bubbles/drops to industrial environmental and biomedical applications

Dutschk

Karapantsios

Liggieri

et al. 2014

Advances in Colloid and Interface Science

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Interfaces can be called Smart and Green (S&G) when tailored such that the required technologies can be implemented with high efficiency, adaptability and selectivity. At the same time they have also to be eco-friendly, i.e. products must be biodegradable, reusable or simply more durable. Bubble and drop interfaces are in many of these smart technologies the fundamental entities and help develop smart products of the everyday life.Significant improvements of these processes and products can be achieved by implementing and manipulating specific properties of these interfaces in a simple and smart way, in order to accomplish specific tasks. The severe environmental issues require in addition attributing ecofriendly features to these interfaces, by incorporating innovative , or, sometime, recycle materials and conceiving new production processes which minimize the use of natural resources and energy. Such concept can be extended to include important societal challenges related to support a sustainable development and a healthy population.The achievement of such ambitious targets requires the technology research to be supported by a robust development of theoretical and experimental tools, needed to understand in more details the behavior of complex interfaces. A wide but not exhaustive review of recent work concerned with green and smart interfaces is presented, addressing different scientific and technological fields. The presented approaches reveal a huge potential in relation to various technological fields, such as nanotechnologies, biotechnologies, medical diagnostics, new or improved materials.

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Effect of Hydrophilic and Hydrophobic Nanoparticles on the Surface Pressure Response of DPPC Monolayers

Cited by 112 publications

References 47 publications

Kupffer cell-mediated hepatic injury induced by silica nanoparticles in vitro and in vivo

Kupffer cell-mediated hepatic injury induced by silica nanoparticles in vitro and in vivo

The comparative immunotoxicity of mesoporous silica nanoparticles and colloidal silica nanoparticles in mice

Smart and green interfaces: From single bubbles/drops to industrial environmental and biomedical applications

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