Effect of hydroxypropyl methylcellulose on obesity and glucose metabolism in a diet-induced obesity mouse model

Abstract

Background: To investigate the effect of hydroxypropyl methylcellulose (HPMC) on weight loss and metabolic disorders associated with obesity using a high‐fat diet‐induced obese mouse model under a high‐fat diet regimen. Methods: Obese male C57BL/6J (B6) mice were fed either a high‐fat (60% kcal), low‐fat (10% kcal), or high‐fat diet plus HPMC (4% and 8%) for 5 weeks. Body, mesenteric adipose, and liver weights were determined at the end of the study. In addition, plasma cholesterol, insulin, glucose, adiponectin, and leptin were analyzed to determine the effects of HPMC. Hepatic and fecal lipids were measured to determine the effect of HPMC on lipid absorption and metabolism. Results: Supplementation of the high‐fat diet with 4% and 8% HPMC resulted in significant weight loss in obese B6 mice. Furthermore, significant decreases were seen in adipose (30%–40%), liver weights (15%–26%), and concentrations of plasma cholesterol (13%–20%) and hepatic lipids (13%–36%). Supplementation with 8% HPMC led to significant improvements in glucose homeostasis and leptin concentrations. Reductions in plasma cholesterol, glucose, and insulin levels were strongly correlated with reduced leptin concentrations. Moreover, increases in fecal secretion of total bile acids, sterols, and fats indicated altered fat absorption when HPMC was incorporated in the diet. Conclusion: The data indicate that HPMC not only reduces body weight, but also normalizes the metabolic abnormalities associated with obesity and suggest that the effects of HPMC on glucose and lipid homeostasis in B6 mice are mediated by improvements in leptin sensitivity resulting from reduced fat absorption.

Bamboo shoot fiber prevents obesity in mice by modulating the gut microbiota

“…The risk factors associated with obesity are linked, in part, to the fat-induced hypertrophy and hyperplasia of adipocytes3536. The present data showed supplementation of a high-fat diet with bamboo shoot fiber suppressed body weight gain through suppressing hyperplasia of adipocytes.…”

Antihyperglycemic and Antioxidative Effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in Mice Fed with a High Fat Diet

“…Nonetheless, both HEMC and HPMC were able to suppress the increase in blood glucose level in mice. Previous studies have shown that diet supplementation with HPMC reduced the blood glucose concentrations in obese mice [6] hamsters [14], and human subjects [7]. This glucose-lowering effect of HPMC has been attributed to its high viscosity, a common property of soluble fibers [1,2].…”

“…Hung et al . [6] also reported a decrease in the insulin level in mice fed with a high fat diet supplemented with HPMC. Moreover, consumption of high viscosity HPMC was shown to significantly blunt the postprandial glucose and insulin responses in obese men and women [18].…”

“…Scientific studies have shown that it could lower the serum cholesterol content in hypercholesterolemic human subjects [2–5] and normalize metabolic abnormalities in obese mice [6]. It was also reported that consumption of HPMC significantly reduced postprandial glucose and insulin responses in overweight and obese men and women [7].…”

Antihyperlipidemic effects of hydroxyethyl methylcellulose with varying viscosity in mice fed with high fat diet

“…Among the methylcellulose fibers, the hydroxypropyl methylcellulose (HPMC) was the most studied in relation to physiological functions. It was reported to reduce body weight and normalized metabolic abnormalities in obese mice (Hung, Anderson, Albers, Langhorst, & Young, 2011) and lower serum cholesterol level in human subjects (Maki, Carson, Miller, et al, 2009;Reppas, Swidan, Tobey, Turowski, & Dressman, 2009). Recently, HEMC was found to have a hypolipidemic action similar to HPMC (Ban, Rico, Um, & Kang, 2011).…”