Effect of hyperthermia combined with external radiation therapy in primary non-small cell lung cancer with direct bony invasion

Sakurai, Hideyuki; Hayakawa, Kazushige; Mitsuhashi, Norio; Tamaki, Yasuhiro; Nakayama, Yuko; Kurosaki, Hiromasa; Nasu, Sachiko; Ishikawa, Hitoshi; Saitoh, Jun‐ichi; Akimoto, Tetsuo; Niibe, Hideo

doi:10.1080/02656730210146917

Cited by 34 publications

(19 citation statements)

References 23 publications

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“…In the field of bone metastases, Fan et al [11] reported that 57 of 62 patients treated with intra-operative microwave-induced hyperthermic treatment had shown excellent local control. Sakurai et al [12] reported that hyperthermic treatment combined with external radiation therapy improved local control in thirteen patients with primary non-small cell lung cancer directly invading to bone.…”

Section: Introductionmentioning

confidence: 98%

A novel hyperthermia treatment for bone metastases using magnetic materials

et al. 2011

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Patients with bone metastases in the extremities sometimes require surgical intervention to prevent deterioration of quality of life due to a pathological fracture. The use of localized radiotherapy combined with surgical reinforcement has been a gold standard for the treatment of bone metastases. However, radiotherapy sometimes induces soft tissue damage, including muscle induration and joint contracture. Moreover, cancer cells are not always radiosensitive. Hyperthermia has been studied since the 1940s using an experimental animal model to treat various types of advanced cancer, and studies have now reached the stage of clinical application, especially in conjunction with radiotherapy or chemotherapy. Nevertheless, bone metastases have several special properties which discourage oncologists from developing hyperthermic therapeutic strategies. First, the bone is located deep in the body, and has low thermal conductivity due to the thickness of cortical bone and the highly vascularized medulla. To address these issues, we developed new hyperthermic strategies which generate heat using magnetic materials under an alternating electromagnetic field, and started clinical application of this treatment modality. The purpose of this review is to summarize the latest studies on hyperthermic treatment in the field of musculoskeletal tumors, and to introduce the treatment strategy employing our novel hyperthermia approach.

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Section: Introductionmentioning

confidence: 98%

A novel hyperthermia treatment for bone metastases using magnetic materials

et al. 2011

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“…In addition, hyperthermia interferes with cellular repair mechanisms of irradiated DNA (9). The timing and treatment parameters of low-temperature hyperthermia induction before XRT are the focus of study in large clinical trials (10,11).…”

Section: Discussionmentioning

confidence: 99%

Radiofrequency Ablation in a Previously Irradiated Liver

Friedman

Altemus

Wood

2003

Journal of Vascular and Interventional Radiology

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A patient with renal cell carcinoma underwent external-beam radiation therapy (XRT) to treat a painful chest-wall metastasis. One month later, she underwent radiofrequency (RF) ablation of two metastatic deposits within the liver; one of the target lesions was in the recent irradiation zone and the other was outside of the radiation field. RF ablation within the irradiated liver produced a slightly larger ablation zone with prominent needle tract scarring, and required less energy input than treatment in the unirradiated liver. RF ablation and XRT may interact, possibly producing a synergistic effect. Further study of the potentially adjunctive relationship between these two modalities is warranted.Current treatment strategies for liver cancer frequently rely on a combination of modalities, including chemotherapy, radiation therapy, and surgery. This multifaceted approach may be more effective than any single therapy. Another tool in the arsenal of cancer therapy is radiofrequency (RF) ablation. RF ablation is a safe and effective technique to destroy focal cancer lesions in a variety of locations, including the liver, bone, and kidney (1-3). Clinical research is currently under way in cancers in the lung, breast, and adrenal gland as well (4-6). RF ablation also has the potential for synergism with traditional cancer treatments, as RF ablation and liposomal chemotherapy have been shown to considerably enhance ablation volumes (7). Although the additive effects of hyperthermia and radiation have been studied at low temperatures (40°C-44°C), there are few data about radiation and the high temperatures of RF ablation (60°C-100°C) (8). Herein we present a case in which the effects of externalbeam radiation treatment (XRT) in combination with RF ablation may account for treatment differences seen with RF ablation of liver metastases. The potential synergism between RF ablation and radiation therapy for local control warrants further investigation. CASE REPORTIn 1969, a 42-year-old woman presented with hematuria secondary to renal-cell carcinoma. She underwent right nephrectomy and XRT to the renal bed; there was no evidence of metastatic disease at that time. Twenty-seven years later, the woman, now 69 years of age, developed biopsy-proven metastases to the pelvis and liver. She was treated with abdominal resection of the pelvic mass followed by XRT, RF ablation of the liver lesion, and administration of interleukin-2, with good response. The following month, the patient developed a painful metastasis to the right chest wall, which was successfully treated with 2,100 cGy of radiation. On this hospital admission, the patient presented with two liver metastases and was referred for RF treatment. There was a 0.9-cm (transverse) by 0.8-cm (anteroposterior) lesion in the anterior section of the left lobe, and a 0.9-cm (transverse) by 0.8-cm (anteroposterior) in the posterior aspect of the right lobe. The region of the posterior

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“…Hyperthermia is now being used more widely, because it does not have as many negative side effects as conventional forms of cancer treatment such as radiation or chemotherapy. In some instances, hyperthermia is used in combination with other forms of cancer therapy (79).…”

Section: Magnetic Fluid Hyperthermiamentioning

confidence: 99%

Physical mechanisms and methods employed in drug delivery to tumors

Bešić¹

2007

Acta Pharmaceutica

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Physical mechanisms and methods employed in drug delivery to tumorsIn addition to several well-known drug delivery strategies developed to facilitate effective chemotherapy with anticancer agents, some new approaches have been recently established, based on specific effects arising from the applications of ultrasound, magnetic and electric fields on drug delivery systems. This paper gives an overview of newly developed methods of drug delivery to tumors and of the related anticancer therapies based on the combined use of different physical methods and specific drug carriers. The conventional strategies and new approaches have been put into perspective to revisit the existing and to propose new directions to overcome the threatening problem of cancer diseases.

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Effect of hyperthermia combined with external radiation therapy in primary non-small cell lung cancer with direct bony invasion

Abstract: Regional hyperthermia combined with conventional irradiation could be a tool to improve local control in patients with NSCLC deeply invading the chest wall.

Cited by 34 publications

References 23 publications

A novel hyperthermia treatment for bone metastases using magnetic materials

A novel hyperthermia treatment for bone metastases using magnetic materials

Radiofrequency Ablation in a Previously Irradiated Liver

Physical mechanisms and methods employed in drug delivery to tumors

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