Effect of hypertransfusion on the gastrointestinal tract after cardiac arrest in a porcine model

Lu, Yi; Liu, Chunsheng; Wang, Shuo

doi:10.5847/wjem.j.issn.1920-8642.2012.01.009

Cited by 3 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…But in some patients, BP can't be monitored on their upper arms because of the wound of skin or infection. Some studies [4,5] considered oscillometric devices for wrist measurement, but most studies have shown that these devices are inaccurate. [6][7][8] BPs at the wrist measured by oscillometric devices generally overestimate BP compared with conventional sphygmomanometry on the upper arm, and the differences could be substantial.…”

Section: Discussionmentioning

confidence: 99%

Discrepancy of blood pressure between the brachial artery and radial artery

Li¹,

Wang²,

Lu³

et al. 2013

World Journal of Emergency Medicine

View full text Add to dashboard Cite

BACKGROUND: In this study, we attempted to fi nd the relations between blood pressure (BP) measured on the brachial artery (bBP) and BP assessed on the radial artery (rBP) in the right arm. METHODS: Three hundred and fifteen patients were enrolled in this study. Those who had peripheral vascular disease, wounds of arm skin or subcutaneous tissue infection were excluded. After a 15-minute equilibration and stabilization period after inducation of anesthesia, three bBP and rBP records were obtained sequentially using an oscillometric device with an adult cuff and infant cuff, respectively. Order for each BP was randomized. RESULTS: The bBP was signifi cantly lower than the rBP (P<0.05). The difference between the two values varied from 13 to 18 mmHg in systolic BP (SBP), diastolic BP (DBP) and mean blood pressure (MAP) respectively. And the rBP was positively correlated with the bBP (r=0.

show abstract

Section: Discussionmentioning

confidence: 99%

Discrepancy of blood pressure between the brachial artery and radial artery

Li¹,

Wang²,

Lu³

et al. 2013

World Journal of Emergency Medicine

View full text Add to dashboard Cite

show abstract

“…Previous study has shown increased activity of DAO in SHRs, and the increase of BP might be related to degradation of putrescine by DAO ( 36 ). Another study connected heart function with the gastrointestinal tract, showing that the plasma level of DAO was significantly elevated after cardiopulmonary resuscitation (CPR) in porcines ( 37 ). To the best of knowledge, our present study is the first study in human that shows that increased DAO in circulation is positively associated with hypertension ( Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…DBP is a risk factor for multiple cardiovascular diseases; similarly ( 39 , 40 ), our results showed that higher DBP was a risk factor for small intestinal mucosal injury. Moreover, poor DBP control may indicate that patients might have increased vascular stiffness or arteriosclerosis, which can decrease intestinal perfusion; interestingly, the lack of perfusion after CPR may induce a decrease of DAO and impaired intestinal integrity ( 37 ). The present study also suggests that hypertension-related renal and cardiac complications are risk factors for intestinal mucosa impairment.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Intestinal Barrier Impairment in Patients With Essential Hypertension

et al. 2021

View full text Add to dashboard Cite

Background: Previous studies have indicated an association between hypertension and intestinal barrier dysfunction in mice models. The present study aims to investigate the association between hypertension and intestinal barrier impairment in humans and identify the novel potential risk factors for hypertension.Methods: Medical data from consecutive inpatients were retrospectively pooled from patient records. We compared intestinal barrier serum markers [diamine oxidase (DAO), lipopolysaccharide (LPS), and D-lactate] between those patients with and without hypertension. Moreover, the associations between intestinal barrier markers and cardiovascular risk, hypertension history, blood pressure control, hypertensive complications, and antihypertensive medication history were also analyzed.Results: Overall, 106 hypertensive and 251 normotensive subjects were included. Patients with hypertension had a higher level of DAO (28.30 vs. 18.73%, P = 0.044) and LPS (22.64 vs. 11.16%, P = 0.005). In hypertensive patients, multivariate logistic regression analyses showed that long hypertension history (≥20 years), poor control of diastolic blood pressure, cardiac and renal complications, and use of multiple antihypertensive medications were risk factors for elevated DAO, while the use of multiple antihypertensive medications was a risk factor for elevated D-lactate (P < 0.05).Conclusions: Hypertension is associated with impairment of intestinal barrier, especially in patients with long duration, poor blood pressure control, cardiac and renal complications, and use of multiple antihypertensive medications. The current study indicates that intestinal barrier dysfunction might be a potential predictor of hypertension.

show abstract

ECMO attenuates inflammation response and increases ATPase activity in brain of swine model with cardiac arrest compared with CCPR

et al. 2019

Self Cite

View full text Add to dashboard Cite

Extracorporeal membrane oxygenation (ECMO) could increase survival rate and neurological outcomes of cardiac arrest (CA) patients compared with conventional cardiopulmonary resuscitation (CCPR). Currently, the underlying mechanisms how ECMO improves neurological outcomes of CA patients compared with CCPR have not been revealed. A pig model of CA was established by ventricular fibrillation induction and then underwent CCPR or ECMO. Survival and hemodynamics during the 6 h after return of spontaneous circulation (ROSC) were compared. The levels of inflammatory cytokines and Ca2+-ATPase and NA+-K+-ATPase activities were detected. Brain tissues histology and ultra-microstructure in CCPR and ECMO groups were also examined. Results suggested that ECMO significantly improved the survival of pigs compared with CCPR. Heart rate (HR) decreased while cardiac output (CO) increased along with the time after ROSC in both ECMO and CCPR groups. At each time point, HR in ECMO groups was lower than that in CCPR group while CO and mean arterial pressure in ECMO group was higher than CCPR group. In ECMO group, lower levels of IL-1, IL-1β, IL-6, TNFα, and TGFβ, especially IL-1, IL-6, TNFα, and TGFβ, were found compared that in CCPR group while no difference of IL-10 between the two groups was observed. Similar with the results from enzyme-linked immunosorbent assay, decreased expressions of IL-6 and TGFβ were also identified by Western blotting. And Ca2+-ATPase and NA+-K+-ATPase activities were increased by ECMO compared with CCPR. Hematoxylin and eosin staining and ultra-microstructure examination also revealed an improved inflammation situation in ECMO group compared with CCPR group.

show abstract

Effect of hypertransfusion on the gastrointestinal tract after cardiac arrest in a porcine model

Cited by 3 publications

References 13 publications

Discrepancy of blood pressure between the brachial artery and radial artery

Discrepancy of blood pressure between the brachial artery and radial artery

Risk Factors for Intestinal Barrier Impairment in Patients With Essential Hypertension

ECMO attenuates inflammation response and increases ATPase activity in brain of swine model with cardiac arrest compared with CCPR

Contact Info

Product

Resources

About