Effect of Hypoxia on Fetal Rabbit Gastrointestinal Motility

Sase, Masakatsu; Lee, Jeong J.; Ross, Michael G.; Buchmiller-Crair, Terry L.

doi:10.1006/jsre.2001.6189

Cited by 20 publications

(7 citation statements)

References 18 publications

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“…It may be suggested that intrauterine hypoxic and vasoconstructive effects of nicotine reduce intestinal blood flow causing intestinal mucosal injury and increased mucosal sensitivity. Sase et al [17] demonstrated that fetal rabbit gastrointestinal motility had been significantly decreased by maternal hypoxia during the last third of gestation. They concluded that hypoxia-induced reduction of gastrointestinal motility of fetus might contribute to neonatal NEC.…”

Section: Discussionmentioning

confidence: 98%

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Does maternal nicotine exposure during gestation increase the injury severity of small intestine in the newborn rats subjected to experimental necrotizing enterocolitis

Özkan

Özokutan

İnanç

et al. 2005

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 98%

“…It was demonstrated that maternal hypoxia during the last third of gestation significantly decreased fetal rabbit gastrointestinal motility which might contribute to neonatal NEC [17]. As in previous studies in sheep and monkeys, nicotine significantly increased maternal arterial pressure and decreased uterine blood flow [18 -20].…”

mentioning

confidence: 89%

Does maternal nicotine exposure during gestation increase the injury severity of small intestine in the newborn rats subjected to experimental necrotizing enterocolitis

Özkan

Özokutan

İnanç

et al. 2005

Journal of Pediatric Surgery

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“…Although we found a decrease in blood flow to the gastrointestinal flow during hypothermic CPB, this flow drop did not correlate with the TSA. However, a decreased mesenteric blood flow as a result of reduced systemic blood flow did cause an inadequate tissue oxygenation in the gastrointestinal tract (23), a metabolic disturbance that may influence the gastrointestinal motility (24). Furthermore, it is unclear whether Pavulon, a skeletal muscle relaxation drug used during the experiment, would have influenced the gastrointestinal smooth muscles.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Motility During Cardiopulmonary Bypass: A Sonomicrometric Study

Kroon

Elstrodt

et al. 2006

Artificial Organs

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Cardiopulmonary bypass (CPB) is known to impair the integrity of the gastrointestinal tract. However, little is known about the movement behavior of the gastrointestinal tract during CPB. This study was aimed to assess the gastrointestinal motility with sonomicrometry, a distance measurement using ultrasound, in a porcine model of CPB. Twelve pigs weighing 70-112 kg were having a standard hypothermic CPB for 120 min either with the nonpulsatile flow (n = 6) or the pulsatile flow (n = 6). Before CPB, piezoelectric echo crystals were placed either along the longitudinal or the circular axis of the pylorus. Patterns of gut movement and the total sonomicrometric activity (TSA) were recorded at several time intervals during experiments as qualitative and quantitative parameters of gut motility. Results showed that the intact regular rhythmic pattern of gut movement was detected before CPB. This pattern changed little when CPB started, but it disappeared at 60 min when the body temperature lowered down to 32 degrees Celsius. During the same period, the TSA reduced significantly along the longitudinal as well as the circular directions of the pylorus. There was no significant difference between the nonpulsatile and pulsatile groups. Gut blood flow reduced significantly in both groups, but it was not associated with the reduced sonomicrometric activity. In conclusion, gastrointestinal motility during CPB can be measured qualitatively and quantitatively by sonomicrometry in a large animal model. Suppression of gut motility during CPB does not seem to be associated with the mode of perfusion but with the reduced body temperature during the hypothermic phase of CPB.

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“…Reduced oxygen to the small intestine induces mucosal injury and may contribute to neonatal NEC. Since little is known about the relationship between fetal hypoxia and GI motility, Sase et al 23 assessed the potential effects using a rabbit model. These experiments gave insight into the GI motility, proving that it was significantly decreased by maternal hypoxia during the last third of gestation.…”

Section: Animal Modelsmentioning

confidence: 99%

Animal models of necrotizing enterocolitis

Mendez

Khan

Perrier

et al. 2020

World Jnl Ped Surgery

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BackgroundNecrotizing enterocolitis (NEC) is one of the leading causes of death in premature infants. To determine the factors present in the disease that lead to increased morbidity and mortality, manipulation of variables that are shown to have a positive response has been tested using various animal models. Testing and manipulation of these variables are unwarranted in humans due to regulatory health standards.MethodsThe purpose of this review is to provide an update to previous summaries that determine the significance of animal models in studying the mechanisms of NEC. A large variety of animal models including rats, mice, rabbits, piglets, nonhuman primates, and quails have been described in literature. We reviewed the reported animal models of NEC and examined the pros and cons of the various models as well as the scientific question addressed.ResultsThe animals used in these experiments were subject to gavage feeding, hypoxia, hypothermia, oxygen perfusion, and other methods to induce the disease state. Each of these models has been utilized to show the effects of NEC on the premature, undeveloped gut in animals to find a correlation to the disease state present in humans. We found specific advantages and disadvantages for each model.ConclusionsRecent advances in our understanding of NEC and the ongoing therapeutic strategy developments underscore the importance of animal models for this disease.

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Effect of Hypoxia on Fetal Rabbit Gastrointestinal Motility

Cited by 20 publications

References 18 publications

Does maternal nicotine exposure during gestation increase the injury severity of small intestine in the newborn rats subjected to experimental necrotizing enterocolitis

Does maternal nicotine exposure during gestation increase the injury severity of small intestine in the newborn rats subjected to experimental necrotizing enterocolitis

Gastrointestinal Motility During Cardiopulmonary Bypass: A Sonomicrometric Study

Animal models of necrotizing enterocolitis

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