Effect of hysteroscopic examination on the outcome of in vitro fertilization

Trninić-Pjević, Aleksandra; Kopitović, Vesna; Pop-Trajkovic, Sonja; Bjelica, Artur; Bujas, Irena; Tabs, Dunja; Ilić, Djordje; Stajic, Dragan

doi:10.2298/vsp1106476t

Cited by 12 publications

(3 citation statements)

References 15 publications

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“…In their meta-analyses, Pundir and El-Toukhy found the proof of the hysteroscopy benefit prior to the first IVF cycle, proving a higher pregnancy rate with women who underwent hysteroscopy procedure [4]. One more research with 480 patients also showed higher pregnancy rates when hysteroscopy was performed before the first IVF [14]. Our study did not provide information about hysteroscopy itself influencing statistically better IVF outcome results.…”

Section: Discussioncontrasting

confidence: 54%

Hysteroscopy Before in Vitro Fertilization

et al. 2018

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In the last decade, success after in vitro fertilization process (IVF) has remained at a similar rate despite all the improvements implemented in the stimulation protocols and laboratory techniques. Hysteroscopy is a method becoming more widely used with patients after a failed IVF cycle, considering a large incidence of uterus cavum pathological states which have a negative impact on the favorable outcome. Numerous studies have provided different results on the IVF outcome with hysteroscopy performed prior to this treatment in cases with no uterus cavum pathology. The aim of the research was to examine the effect of both diagnostic and surgical hysteroscopy on the outcome of IVF. Hysteroscopy was performed with 74 patients 30 to 50 days prior to IVF and in 33 of them (group I) some pathological state was noticed, which was treated during the same procedure. The control group (group III) included 151 patients who had IVF performed with no prior hysteroscopy. There is no statistically significant difference in the rate of post hysteroscopy implantation between I and II group when compared to the control group (20.62% vs 23.28% vs 17.31%), nor in the rate of clinical pregnancies (45.45% vs 46.34% vs 34.44%). Following the correctional treatment of uterus cavum pathological states, implantation and pregnancy rates remain at a level comparable to hysteroscopically normal medical findings. Statistically significant higher pregnancy rate is present in group I after the first IVF cycle, compared to the next IVF in the same group and in comparison to the next IVF cycle in the control group (60.00% vs 27.91%, p<0.05). Hysteroscopy is a simple and safe method allowing nearly identical rate of clinical pregnancies after a surgical treatment of uterus cavum pathological states when compared to the control group, but statistically much higher pregnancy rate if the order of IVF procedure is being compared. In cases of normal ultrasound findings and negative hysteroscopical findings, performing hysteroscopy prior to IVF does not provide significantly better results. Therefore, its routine execution is not recommended.

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Section: Discussioncontrasting

confidence: 54%

Hysteroscopy Before in Vitro Fertilization

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“…2d) was removed from the stomach by surgical intervention. Surgical solution for gastric trichobezoar in children has been mentioned in numerous papers as a method of choice [8,[14][15][16]].…”

Section: Discussionmentioning

confidence: 99%

Initial Experiences in Treatment of Gastrointestinal Foreign Bodies in Children

et al. 2018

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We performed a retrospective analysis of all records of children with ingested foreign bodies presented to Clinical Center of Niš Pediatric Clinic and Pediatric Surgery and Orthopedics Clinic in the period from January 2014 to June 2017. The most commonly detected foreign bodies were: metal coins (7) followed by hairclips (2), metal key (1), trichobezoar (1) magnets (1) button battery (1) and zipper puller (1). Regarding anatomical location, foreign bodies were most frequently found in stomach (in 11 patients) followed by esophagus (in 2 patients) and jejunum (in 1 patient). In the majority of our patients (7) foreign bodies passed out of gastrointestinal tract spontaneously. Endoscopic foreign body removal was performed in 5 cases while surgery as a sole therapeutic action was done in 1 patient. In one child multiple magnets were removed from the stomach performing both endoscopic and surgical interventions. Teamwork of a gastroenterologist and a surgeon is crucial for optimizing therapeutic options for each individual patient. Public awareness of this problem and education of parents should be increased to a higher level in order to prevent cases of foreign bodies ingestion in children.

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“…The idea of performing hysteroscopy prior to every IVF procedure was greatly favored for two reasons: due to high frequency of uterus cavum pathological states (10%-60%) and the influence of hysteroscopy itself on the better IVF outcome 1,2 .…”

Section: Introductionmentioning

confidence: 99%

The effects of local endometrial injury by hysteroscopy on in vitro fertilization outcome

et al. 2018

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Bacngraund/Aim. Regardless of embryos quality, an appropriate endometrial thickness and a successful embryo transfer (ET), implantation remains a difficulty for a favorable outcome of an in vitro fertilization (IVF). Numerous studies with the aim of increasing implantation rate and pregnancy rate suggest local endometrial injury (LEI) prior to the IVF procedure. Hysteroscopy is a method becoming more widely used both with patients after a failed IVF cycle and with patients before the first IVF, considering the large incidence of uterus cavum pathological states which have a negative impact on the favorable outcome. However, there is still no consensus reached over LEI, the way and time of its performing or its impact. The aim of this research was to determine the effect of hysteroscopically made local endometrial lesion on the IVF procedure outcome, both in the first and in the next IVF cycle and also to examine if the new method of LEI provoking using bipolare electrode has a favorable impact on post IVF pregnancy success. Methods. Total of 81 patients had hysteroscopy performed 30-50 days prior to IVF, 40 of which had LEI made during hysteroscopy (the LEI group) using bipolar electrode in a way not described in any available literature. Remaning his-teroscopically treated patients (n = 41) had no LEI (the non-LEI group). The control group included 151 patient who had IVF performed with no prior hysteroscopy and LEI. Results. The rate of clinical pregnancies after LEI was statistically more significant in comparison to the control group (52.50% vs 34.44%, p < 0.05) and it meant 2.1 time bigger chance to conceive (OR=2.10; 95% CI: 1.04-4.26; p < 0.05). We noticed differences in the implantation rate between the LEI group and the non-LEI group on one side and the control group on the other, in favor of the two groups subjected to hysteroscopy (23.89%, 25.47% vs 18.18%, respectively), but they were not of any statistical significance. Not significantly higher rate of pregnancy was present, after the first and the next IVF, both in the LEI and the non-LEI group when compared to the control one. Conclusion. New method of LEI provoking by bipolar electrode in the process of hysteroscopy is a simple and safe method allowing higher rate of clinical pregnancies and doubling the probabilty of the positive IVF outcome.

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Effect of hysteroscopic examination on the outcome of in vitro fertilization

Abstract: Considering the results of this study we could conclude that hysteroscopy, as a routine examination, should be performed before the first IVF-ET cycle in all patients thereby reducing the failures and then the costs of IVF-ET.

Cited by 12 publications

References 15 publications

Hysteroscopy Before in Vitro Fertilization

Hysteroscopy Before in Vitro Fertilization

Initial Experiences in Treatment of Gastrointestinal Foreign Bodies in Children

The effects of local endometrial injury by hysteroscopy on in vitro fertilization outcome

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