Effect of<i>Arctium lappa</i>L. in the dextran sulfate sodium colitis mouse model

Huang, Tzou‐Chi; Tsai, Shinn-Shyong; Liu, Lifang; Liu, Yu Lin; Liu, Hung-Jen; Chuang, Kui-Hao

doi:10.3748/wjg.v16.i33.4193

Cited by 51 publications

(39 citation statements)

References 22 publications

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“…It is well known that the percentage of DSS exposure and colony of animal closely relate to the success of the UC model (Elvington et al , ; Johswich et al , ; Wang et al , ). Commonly, a higher percentage (5%, w / v ) of DSS is employed to establish an acute UC model, to elicit serious colon injury (Huang et al , ; Wadie et al , ; Wang et al , ). In the present study, Sprague–Dawley rats were given drinking water containing 5% ( w / v ) DSS ad libitum for 7 days to induce acute colitis, and on day 4, the majority of rats exposed to DSS presented with serious mucopurulent stool (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of 6‐Gingerol, 8‐Gingerol, and 10‐Gingerol on Dextran Sulfate Sodium‐Induced Acute Ulcerative Colitis in Rats

Zhang

Gao

et al. 2017

Phytotherapy Research

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Ulcerative colitis is one of the most common types of inflammatory bowel disease and is multifactorial and relapsing. 6-Gingerol, a component of gingerols extracted from ginger (Zingiber officinale), has been reported to improve ulcerative colitis. The present study aims to investigate the therapeutic efficacy of two analogous forms of 6-gingerol, 8-gingerol, and 10-gingerol, on ulcerative colitis. Colitis was induced in rats through consumption of 5% (w/v) dextran sulfate sodium drinking water for 7 consecutive days. 6-Gingerol, 8-gingerol, and 10-gingerol were then given intraperitoneally at doses of 30 mg kg d for another 7 days, respectively. Body weight change, disease activity index, inflammatory cytokines, and oxidative stress indices were measured, and the colonic tissue injuries were assessed macroscopically and histopathologically. Results showed that all three gingerols attenuated colitic symptoms evoked by dextran sulfate sodium, significantly elevated superoxide dismutase activity, decreased malondialdehyde levels and myeloperoxidase activity in the colon tissue, and markedly reduced the content of tumor necrosis factor alpha and Interleukin 1 beta in the serum. Histological observations showed that all three gingerols obviously accelerated mucosal damage healing. It is concluded that 6-gingerol, 8-gingerol, and 10-gingerol, the three analogues, have a strong and relatively equal efficacy in the treatment of colitis. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of 6‐Gingerol, 8‐Gingerol, and 10‐Gingerol on Dextran Sulfate Sodium‐Induced Acute Ulcerative Colitis in Rats

Zhang

Gao

et al. 2017

Phytotherapy Research

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“…Using this model, we found that W. chinensis could effectively attenuate specific clinical symptoms and provide protection against the histopathological changes caused by colonic inflammation. Previous studies have shown that specific medicinal herbs, such as Arctium lappa (burdock) and Scutelleria baicalensis , can confer anti-colitis activities [34], [35]. Comparison with results from these studies suggested that WCHF extract from W. chinensis had a considerably lower effective dosage (e.g., 50, 100 and 1000 mg/kg for W. chinensis , A. lappa and S. baicalensis , respectively) than the previously tested medicinal plants [34], [35].…”

Section: Discussionmentioning

confidence: 99%

Dietary Uptake of Wedelia chinensis Extract Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice

Huang

Wen²,

Chen

et al. 2013

PLoS ONE

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ScopeTraditional medicinal herbs are increasingly used as alternative therapies in patients with inflammatory diseases. Here we evaluated the effect of Wedelia chinensis, a medicinal herb commonly used in Asia, on the prevention of dextran sulfate sodium (DSS)-induced acute colitis in mice. General safety and the effect of different extraction methods on the bioactivity of W. chinensis were also explored.Methods and ResultsC57BL/6 mice were administrated hot water extract of fresh W. chinensis (WCHF) orally for one week followed by drinking water containing 2% DSS for nine days. WCHF significantly attenuated the symptoms of colitis including diarrhea, rectal bleeding and loss of body weight; it also reduced the shortening of colon length and histopathological damage caused by colonic inflammation. Among four W. chinensis extracts prepared using different extraction techniques, WCHF showed the highest anti-colitis efficacy. Analyses of specific T-cell regulatory cytokines (TNF-α, IL-4, IFN-γ, IL-17, TGF-β, IL-12) revealed that WCHF treatment can suppress the Th1 and Th17, but not Th2, responses in colon tissues and dendritic cells of DSS-induced colitis mice. A 28-day subacute toxicity study showed that daily oral administration of WCHF (100, 500, 1000 mg/kg body weight) was not toxic to mice.ConclusionTogether, our findings suggest that specific extracts of W. chinensis have nutritional potential for future development into nutraceuticals or dietary supplements for treatment of inflammatory bowel disease.

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“…Fructus arctii have been reported to have antimicrobial, antioxidant, and anti-inflammatory activities (Lin et al, 1996;Huang et al, 2010). Research on the chemical compositions of Fructus arctii has shown that the most active ingredient of Fructus arctii is arctigenin (C 21 H 24 O 6 with a molecular weight of 372.41), a phenylpropanoid dibenzylbutyrolactone lignan (Hirose et al, 2000;Cho et al, 2004;Huang et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Arctigenin Anti‐Tumor Activity in Bladder Cancer T24 Cell Line Through Induction of Cell‐Cycle Arrest and Apoptosis

Yang

Xiao

et al. 2012

The Anatomical Record

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Bladder cancer is the most common neoplasm in the urinary system. This study assesses arctigenin anti-tumor activity in human bladder cancer T24 cells in vitro and the underlying molecular events. The flow cytometry analysis was used to detect cell-cycle distribution and apoptosis. Western blotting was used to detect changes in protein expression. The data showed that arctigenin treatment reduced viability of bladder cancer T24 cells in a dose-and time-dependent manner after treatment with arctigenin (10, 20, 40, 80, and 100 lmol/L) for 24 hr and 48 hr. Arctigenin treatment clearly arrested tumor cells in the G1 phase of the cell cycle. Apoptosis was detected by hoechst stain and flow cytometry after Annexin-V-FITC/PI double staining. Early and late apoptotic cells were accounted for 2.32-7.01% and 3.07-7.35%, respectively. At the molecular level, arctigenin treatment decreased cyclin D1 expression, whereas CDK4 and CDK6 expression levels were unaffected. Moreover, arctigenin selectively altered the phosphorylation of members of the MAPK superfamily, decreasing phosphorylation of ERK1/2 and activated phosphorylation of p38 significantly in a dose-dependent manner. These results suggest that arctigenin may inhibit cell viability and induce apoptosis by direct activation of the mitochondrial pathway, and the mitogen-activated protein kinase pathway may play an important role in the anti-tumor effect of arctigenin. The data from the current study demonstrate the usefulness of arctigenin in bladder cancer T24 cells, which should further be evaluated in vivo before translation into clinical trials for the chemoprevention of bladder cancer. Anat

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Effect ofArctium lappaL. in the dextran sulfate sodium colitis mouse model

Abstract: We suggest that AL can prevent intestinal damage and decrease inflammatory cytokines in mice with DSS-induced colitis. Thus, AL could prove to be a useful food for UC.

Cited by 51 publications

References 22 publications

Therapeutic Effects of 6‐Gingerol, 8‐Gingerol, and 10‐Gingerol on Dextran Sulfate Sodium‐Induced Acute Ulcerative Colitis in Rats

Therapeutic Effects of 6‐Gingerol, 8‐Gingerol, and 10‐Gingerol on Dextran Sulfate Sodium‐Induced Acute Ulcerative Colitis in Rats

Dietary Uptake of Wedelia chinensis Extract Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice

Arctigenin Anti‐Tumor Activity in Bladder Cancer T24 Cell Line Through Induction of Cell‐Cycle Arrest and Apoptosis

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