Effect of <i>Costaria costata</i> Fucoidan on Expression of Matrix Metalloproteinase-1 Promoter, mRNA, and Protein

Moon, Hee Jung; Park, Kyong Sik; Ku, Mi Jeong; Lee, Myeong Sook; Jeong, Seok Hoon; Имбс, Т. И.; Zvyagintseva, T. N.; Ermakova, Svetlana P.; Lee, Yong Hwan

doi:10.1021/np800797v

Cited by 54 publications

(28 citation statements)

References 34 publications

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“…They have a heparin-like anticoagulant activity, inhibit selectin function, inhibit viral entry to cells, and appear to be immunomodulatory. Fucoidans from different species have been shown to inhibit Ultra-violet (UV)-induced matrix metalloprotease (MMP) expression in vitro [2][3][4]. Senni showed that fucoidans are extensive inhibitors of matrix metalloproteases, while fucoidan (or fucoidan-containing) extracts from Fucus vesiculosus and Ascophyllum nodosum have been shown to inhibit elastase [5,6].…”

Section: Introductionmentioning

confidence: 99%

Topical Benefits of Two Fucoidan-Rich Extracts from Marine Macroalgae

Fitton¹,

Dell'Acqua²,

Gardiner³

et al. 2015

Cosmetics

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Abstract:Two concentrated and well-characterized fucoidan-rich extracts were investigated to determine their benefits in topical applications. An Undaria pinnatifida extract, containing 85% fucoidan, and a Fucus vesiculosus co-extract, containing 60% fucoidan and 30% polyphenol, were assessed in a number of in vitro assays to measure the effect of the extracts on enzyme inhibition, glycation, antioxidant activity and Sirtuin 1 (SIRT1) protein expression. Double-blind, placebo-controlled clinical studies were also conducted to measure soothing, protection, wrinkle depth, brightness and skin spot intensity. Both extracts demonstrated marked inhibitory effects on processes linked to skin aging, including the increased expression of SIRT1 in vitro. Clinical testing established the efficacy of the extracts in a range of the tested applications, relative to placebo. The Fucus vesiculosus extract with high polyphenol content demonstrated additional in vitro antioxidant activity, as well as improved efficacy in skin brightening applications, relative to placebo. The major effects of the Undaria pinnatifida extract aided skin immunity, soothing and protection, while the Fucus vesiculosus extract most significantly affected age spot reduction and increased brightness, soothing and protection. OPEN ACCESSCosmetics 2015, 2 67

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Section: Introductionmentioning

confidence: 99%

Topical Benefits of Two Fucoidan-Rich Extracts from Marine Macroalgae

Fitton¹,

Dell'Acqua²,

Gardiner³

et al. 2015

Cosmetics

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“…Here, LMF treatment down-regulated the gene expression of MMP-1, MMP-9 and MMP-13. Previous studies have shown that native fucoidans modulate MMP-1 expression in human fibroblasts [14,15,16]. Furthermore, l -fucose and fucose-rich polysaccharides have a direct relationship with increased synthesis of elastin and collagen by down-regulating MMPs, particularly MMP-2 and MMP-9 [29,30,31].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, unlike native fucoidan with a high molecular-weight of approximately 20,000 kDa, low molecular-weight fucoidan (LMF)—less than 10 kDa—has shown more biological activities because of its high absorption and bioavailability [13]. However, a few studies have examined the anti-photoaging effect of fucoidans, which include three in vitro studies demonstrating the down-regulating effects on MMP-1 [14,15,16] and one in vivo study showing inhibitory effects on inflammation and MMP-1 expression following oral administration [17]. We previously showed that topical application of LMF has dermal wound healing effects with anti-inflammatory and antioxidant activities and modulates ECM rebuilding factors, such as transforming growth factor (TGF)-β1, fibroblast growth factor (FGF)-2, and MMPs [18].…”

Section: Introductionmentioning

confidence: 99%

Anti-Photoaging Effects of Low Molecular-Weight Fucoidan on Ultraviolet B-Irradiated Mice

Kim

Song

et al. 2018

Marine Drugs

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Ultraviolet (UV) B exposure induces DNA damage and production of reactive oxygen species (ROS), which causes skin photoaging through signaling pathways of inflammation and modulation of extracellular matrix remodeling proteins, collagens, and matrix metalloproteinase (MMP). As low molecular-weight fucoidan (LMF) has potential antioxidant and anti-inflammatory properties, we examined the protective effects of LMF against UVB-induced photoaging. A UVB-irradiated mouse model was topically treated with myricetin or LMF at 2.0, 1.0 and 0.2 mg/cm2 (LMF2.0, LMF1.0 and LMF0.2, respectively) once a day for 15 weeks. Wrinkle formation, inflammation, oxidative stress, MMP expression, and apoptosis in the treated regions were compared with those in a distilled water-treated photoaging model (UVB control). LMF treatments, particularly LMF2.0 and LMF1.0, significantly inhibited the wrinkle formation, skin edema, and neutrophil recruitment into the photo-damaged lesions, compared with those in the UVB control. While LMF decreased interleukin (IL)-1β release, it increased IL-10. The LMF treatment inhibited the oxidative stresses (malondialdehyde and superoxide anion) and enhanced endogenous antioxidants (glutathione). Additionally, LMF reduced the mRNA expression of MMP-1, 9, and 13. The histopathological analyses revealed the anti-photoaging effects of LMF exerted via its antioxidant, anti-apoptotic, and MMP-9-inhibiting effects. These suggest that LMF can be used as a skin-protective remedy for photoaging.

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“…Fucoidans extracted by these techniques exhibited in some cases a higher antioxidant activity than those extracted by conventional methods [53]. In addition to their antioxidant properties, fucoidans possess another biological activity relevant in the cosmetic field: they are able to prevent UVB-induced matrix metalloproteinase-1 (MMP-1) expression and suppress MMP-3 in vitro [39,55]. MMPs induce degradation of dermal proteins such as collagen, fibronectin and elastin, contributing to skin damage; therefore fucoidan may be useful to prevent skin photoaging not only by scavenging ROS formed during exposition to UV radiations, but also by inhibiting the formation of MMPs.…”

Section: Anti-pollution Ingredients From Algaementioning

confidence: 99%

Cosmetic Functional Ingredients from Botanical Sources for Anti-Pollution Skincare Products

Juliano

Magrini

2018

Cosmetics

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Air pollution is a rising problem in many metropolitan areas around the world. Airborne contaminants are predominantly derived from anthropogenic activities, and include carbon monoxide, sulfur dioxide, nitrogen oxides, volatile organic compounds, ozone and particulate matter (PM; a mixture of solid and liquid particles of variable size and composition, able to absorb and delivery a large number of pollutants). The exposure to these air pollutants is associated to detrimental effects on human skin, such as premature aging, pigment spot formation, skin rashes and eczema, and can worsen some skin conditions, such as atopic dermatitis. A cosmetic approach to this problem involves the topical application of skincare products containing functional ingredients able to counteract pollution-induced skin damage. Considering that the demand for natural actives is growing in all segments of global cosmetic market, the aim of this review is to describe some commercial cosmetic ingredients obtained from botanical sources able to reduce the impact of air pollutants on human skin with different mechanisms, providing a scientific rationale for their use.

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Effect of Costaria costata Fucoidan on Expression of Matrix Metalloproteinase-1 Promoter, mRNA, and Protein

Cited by 54 publications

References 34 publications

Topical Benefits of Two Fucoidan-Rich Extracts from Marine Macroalgae

Topical Benefits of Two Fucoidan-Rich Extracts from Marine Macroalgae

Anti-Photoaging Effects of Low Molecular-Weight Fucoidan on Ultraviolet B-Irradiated Mice

Cosmetic Functional Ingredients from Botanical Sources for Anti-Pollution Skincare Products

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