Effect ofFalcaria vulgarisextracts on sperm parameters in diabetic rats

Abstract

Diabetes causes a systemic inflammatory response with increased oxidative stress and can adversely effect spermatogenesis. Sickle-weed plant, scientifically called Falcaria vlugaris, contains antioxidants and antimicrobial ingredients. The aim of this study was to determine the effect of Falcaria vulgaris vulgaris extract on the sperm parameters of diabetic rats. In this experimental study, diabetes was induced in the animals using streptozotocin (STZ; 60 mg/kg). Sixty-four rats were equally divided into eight groups as follows: nondiabetic (normal) controls; normal rats given 50, 100 or 150 mg/kg doses of F. vulgaris extract; diabetic controls induced by STZ; and diabetic animals that received STZ plus 50, 100 or 150 mg/kg F. vulgaris extract. The animals were injected with the extract intraperitoneally once a day for 28 consecutive days. The sperm parameters of count, motility, morphology, viability, total antioxidant capacity and seminiferous tube diameter were analysed and compared. The results indicated that the values of all parameters decreased significantly in the diabetic control groups compared to the normal control group (p < 0.00). The parameters of the diabetic groups that received 50, 100 or 150 mg/kg F. vulgaris extract showed significant increases in all parameters at all doses compared to the diabetic control group (p ≤ 0.001). The administration of F. vulgaris extract as a potent antioxidant was able to compensate for the toxicity induced by STZ and increase the quality of some spermatozoa.

Effects of gallic acid on rat testopathy following morphine administration: an experimental study

“…MOR can induce an increased level of oxidative stress, DNA damage, peroxidation lipid, as well as formation of additional protein compounds by producing ROS such as superoxide and hydrogen peroxide (8). An increased state of differentiation was reported in seminiferous tubules in the MOR control group in which the increased diameter of the tubules is probable (23). In addition, increasing state of ROS with increasing lipid peroxidation leads to induction of tubules' atrophy and apoptosis of the germ cells (9).…”

“…The first consequence of the ROS attack to the structure of membrane is occurrence of cell peroxidation within the cellular and organelles membrane. Since a large amount of sperm cytoplasm will be lost following the spermatogenesis, it is reported to be more sensitive to the presence of ROS than somatic cells due to the lack of antioxidant systems (23). It seems that high levels of ROS can reduce the spermatozoal motility because of the effect on Ca++ channels and reduction in spermatozoa ATP reserves (24).…”

Ameliorative Effect of Falcaria vulgaris on Nicotine-induced Injury on the Hippocampus Dentate Gyrus Region of Rats

“…25 FV seems to inhibit lipid peroxidation of quinolinic acid and control the production of cyanide-induced superoxide. 4 FV extract can increase the effects of antioxidant enzymes such as catalase and superoxide dismutase and reduce ROS production. 16 The present study showed a significant increase in serum nitrite oxide level in the nicotine group compared to the sham group.…”

“…In the second nicotine group, each animal received 0.5 mg/kg single dose course of nicotine, intraperitoneally and the solvent of nicotine was normal saline. 10 The third to fifth groups included the FV groups, in which each animal respectively received 50, 100 and 150 mg/ kg of FV intraperitoneally for 28 days at 10 a.m. 1,2,4 The sixth to eighth groups include nicotine + FV groups, in which each animal received a single dose of 0.5 mg/kg nicotine in order to induce damage and then respectively received 50, 100 and 150 mg/kg of FV intraperitoneally for 28 day at 10 a.m.…”

“…3 Phytochemical studies on this medicinal plant have shown the presence of Tannins and Saponin. 4 This plant contains Vitamin C, phytosterol, protein and starchy materials and is a rich source of tannins and ascorbic acid. Similar to antibiotics, it can be used for the treatment of skin ulcers.…”