Effect of Gymnema montanum Leaves on Serum and Tissue Lipids in Alloxan Diabetic Rats

Abstract

The effect of Gymnema montanum leaves on alloxaninduced hyperlipidemia was studied in male Wistar rats. Ethanolic extract of G. montanum leaves was administered orally and different doses of the extract on blood glucose, serum and tissue lipids, hexokinase, glucose-6-phosphatase, thiobarbituric acid-reactive substances (TBARS), hydroperoxides, and glutathione in alloxan-induced diabetic rats were studied. G. montanum leaf extract (GLEt) at doses of 50, 100, 200 mg/kg body weight for 3 weeks suppressed the elevated blood glucose and lipid levels in diabetic rats. GLEt at 200 mg/kg body weight was found to be comparable to glibenclamide, a reference drug. These data indicate that G. montanum represents an effective antihyperglycemic and antihyperlipidemic adjunct for the treatment of diabetes and a potential source of discovery of new orally active agent for future therapy.Keywords Alloxan Diabetes; Blood Glucose; Carbohydrate Enzymes; Gymnema montanum; Lipids Experimental diabetes in animals has provided considerable insight into the physiologic and biochemical derangements of the diabetic state. Many of the derangements have been characterized in hyperglycemic animals. Significant changes in lipid metabolism and structure also occur in diabetes [1]. In these cases, the structural changes are clearly oxidative in nature and

Antidiabetic activity of Helicteres angustifolia root

“…This study for the first time confirms that the ethanol extract of H. angustifolia root has antidiabetic effects by stimulating glucose uptake in HepG2 cells, C2C12 myotubes, and 3T3-L1 adipocytes. Hypertriglyceridaemia and hypercholesterolaemia have been reported to be the primary factors of diabetic state involving in the development of atherosclerosis and coronary heart disease which are the secondary complications of diabetes (Ananthan et al 2003). Results from this study indicate that the extract administration could significantly reduce TG and TC levels while significantly increase HDL-C level in the STZ-induced diabetic rats.…”

Antioxidant and Antihyperglycemic Effects of Ferula drudeana and Ferula huber-morathii in Experimental Diabetic Rats

“…Moreover, insulin reduces elevated cholesterol by different mechanisms, such as; increasing uptake of fatty acids into peripheral tissue and inhibiting lipolysis. In case of insulin resistance circumstances, lipolysis is not inhibited and leads to hyperlipidemia (Ananthan et al, 2003). These results showed that F. drudeana (400 mg kgG 1 ) and F. huber-morathii (200 and 400 mg kgG 1 ) medication brought back the increased levels of TG, TC and LDL-C of STZ-diabetic rats near to their normal levels.…”

“…Presence of hypertriglyceridemia and hypercholesterolemia and reduction of HDL-C are the most common lipid abnormalities that were reported in diabetic condition (Uttra et al, 2011). Under normal condition, TG is being hydrolyzed by lipoprotein lipase which was activated by insulin (Ananthan et al, 2003). Moreover, insulin reduces elevated cholesterol by different mechanisms, such as; increasing uptake of fatty acids into peripheral tissue and inhibiting lipolysis.…”

Protective effect of Berberis asiatica root on biochemical and histopathological changes in streptozotocin-induced diabetic Wistar rats

“…Diabetic rats exhibited abnormalities in lipid metabolism as evidenced by the elevated levels of cholesterol, triglycerides, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol and low levels of HDL-C in group II. 38,39 Treatment with Berberis asiatica plant extract and standard drug reduced the elevated levels of TC, TG, LDL-C and LDL-C, whereas it showed the improvement in the level of HDL-C.…”