Effect of <i>H. pylori</i> Infection and CagA Status on Leukocyte Counts and Liver Function Tests: Extra‐Gastric Manifestations of <i>H. pylori</i> Infection

Graham, David Y.; Osato, Michael S.; Olson, Carol A.; Zhang, Jie; Figura, Natale

doi:10.1046/j.1523-5378.1998.08018.x

Cited by 38 publications

(32 citation statements)

References 23 publications

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“…Helicobacterpositive patients had higher levels of aspartate aminotransferase and similar levels of alanine transaminase, alkaline phosphatase, and total bilirubin compared with the Helicobacter-negative group, whereas 2 studies in the literature found increased alkaline phosphatase and alanine transaminase in patients with H pylori infection [9,22]. Our results may differ from those in the literature due to the late stage of disease present in our study population.…”

Section: Discussioncontrasting

confidence: 73%

Helicobacter pylori May Play a Contributory Role in the Pathogenesis of Primary Sclerosing Cholangitis

et al. 2007

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Helicobacter pylori (H. pylori) DNA has been identified in human livers and has been implicated in chronic liver disease and liver cancer. To better understand the role of H pylori in primary sclerosing cholangitis (PSC), 25 patients with end-stage PSC and 31 controls were studied. Genomic DNA was extracted from microdissected hilar hepatic ducts of liver explants and was amplified for H pylori DNA. Serum was tested for H pylori antibodies. Helicobacter DNA was detected in 9 of the 56 (16%) patients by 16SrRNA PCR (an additional case [for a total of 18%] was antibody positive). Seven of the 9 cases identified by polymerase chain reaction were positive for the CagA gene, confirming they were H pylori. Seven of the 25 (28%) patients with PSC and 3 of the 31 (9.7%) controls were positive for Helicobacter (P=.087). H pylori DNA was detected in microdissected hilar biliary epithelium in more PSC patients than controls, supporting the hypothesis that bile reflux from the duodenum into the biliary tract might carry H pylori organisms into the proximal biliary system, possibly contributing to PSC development and/or progression in some patients.

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Section: Discussioncontrasting

confidence: 73%

Helicobacter pylori May Play a Contributory Role in the Pathogenesis of Primary Sclerosing Cholangitis

et al. 2007

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“…A possible role for HP in osteoporosis has been suggested due to the fact that HP infection may induce chronic low level systemic inflammatory status. Inflammatory markers such as TNFalpha and IL-6 have roles in bone metabolism 14,21) . TNFalpha increases bone resorption, and IL-6 raises the number of osteoclasts 2) .…”

Section: Discussionmentioning

confidence: 99%

Helicobacter Pylori Seropositivity in Patients with Postmenopausal Osteoporosis

Akkaya

Polat

et al. 2011

J Phys Ther Sci

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Abstract.[Purpose] The results of studies investigating the role of Helicobacter pylori (HP) in osteoporosis are contradictory. In this study we investigated HP seropositivity in postmenopausal osteoporotic and non-osteoporotic females to elucidate the role of HP in postmenopausal osteoporosis. [Subjects and Methods] Serum was collected from fifty-eight osteoporotic patients and forty-seven nonosteoporotic subjects, whose status was diagnosed with dual-energy X-ray absorptiometry (DEXA). None of the subjects had received any prior treatment for osteoporosis. Subjects' sera were assessed for HP antibodies (Immunoglobulin A and G) by enzyme-linked immunoabsorbent assay (ELISA). Patients were interviewed about risk factors of osteoporosis. Prior fractures of patients and familial fracture history were also noted.[Results] Fifty-eight patients with osteoporosis and forty-seven nonosteoporotic patients, as determined by lumbar total or collum femoris in DEXA, were evaluated in this study. The familial fracture history was significantly higher in the osteoporotic patients than in the nonosteoporotic group. There was no significant difference in HP seropositivity between the osteoporotic and nonosteoporotic groups.[Conclusion] There was no difference in HP seropositivity between the groups, therefore HP infection seems not to be an important risk factor for postmenopausal osteoporosis.

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“…Two possible explanations could account for the observed findings: the inflammatory response to the infection and the existence of cross-mimicry phenomena between H. pylori and sperm antigens. The humoral and cellular immune responses to the invading organisms increase the local and systemic indices of inflammation, such as the levels of polymorphs and monocytes [18]. The colonized gastric epithelium and immunocytes stimulated by the bacterial determinants of pathogenicity secrete vasoactive substances and cellular mediators, such as cytokines.…”

Section: Discussionmentioning

confidence: 99%

Infection by CagA-Positive Helicobacter pylori Strains may Contribute to Alter the Sperm Quality of Men with Fertility Disorders and Increase the Systemic Levels of TNF-α

et al. 2009

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This study was aimed to address the possibility that Helicobacter pylori infection may play a detrimental role in semen quality of men with idiopathic infertility. Infection by H. pylori and by strains expressing CagA was determined in 80 male infertile patients by Western blotting and ELISA. Semen analysis was performed by light microscopy and transmission electron microscopy quantitatively elaborated (fertility index, immaturity, necrosis, and apoptosis percentages). Systemic levels of IL-6 and TNF-alpha were evaluated. Infertile patients infected with H. pylori showed a low sperm quality respective to uninfected patients. Particularly, in CagA-positive patients we observed a significant reduction in sperm motility and in the fertility index, while apoptosis and necrosis were increased. In these patients, the means of systemic TNF-alpha levels were higher than those of uninfected patients. The negative influence of CagA-positive H. pylori infection on sperm quality may help to understand the role of chronic infections in reproductive disorders.

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Effect of H. pylori Infection and CagA Status on Leukocyte Counts and Liver Function Tests: Extra‐Gastric Manifestations of H. pylori Infection

Cited by 38 publications

References 23 publications

Helicobacter pylori May Play a Contributory Role in the Pathogenesis of Primary Sclerosing Cholangitis

Helicobacter pylori May Play a Contributory Role in the Pathogenesis of Primary Sclerosing Cholangitis

Helicobacter Pylori Seropositivity in Patients with Postmenopausal Osteoporosis

Infection by CagA-Positive Helicobacter pylori Strains may Contribute to Alter the Sperm Quality of Men with Fertility Disorders and Increase the Systemic Levels of TNF-α

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