Effect of Helicobacter pylori Infection on Serum Lipid Profile

Abstract

Background Some studies suggest a significant relationship between Helicobacter pylori infection and atherogenesis; but the mechanism of the relationship is almost unknown. The current study aimed at evaluating the relationship between H. pylori infection and serum lipid profile. Patients and Methods The current study was conducted on 2573 patients, from 2008 to 2015. The serum anti-Helicobacter pylori antibody titer and serum lipid profile were assessed in the study population; data were statistically analyzed by SPSS version 16. P values < 0.05 were considered significant. Results In the current study, 66.5% of the cases were serologically positive for H. pylori. Among male cases, the level of low density lipoprotein (LDL) was higher in patients with H. pylori infection, compared with that of the ones without the infection (P = 0.03); although level of triglyceride (TG) was higher and the level of high density lipoprotein (HDL) was lower in the cases with H. pylori infection; there was no statistically significant difference between the cases with and without H. pylori infection regarding the level of HDL and TG. Among female cases, the level of TG was significantly lower in patients with H. pylori infection, compared with that of the ones without the infection (P = 0.001); but there was no significant difference between the cases with and without H. pylori infection regarding the level of LDL and HDL. The mean fasting blood sugar (FBS) in the cases with H. pylori infection was significantly higher than that of the ones without the infection (P = 0.04). Conclusion According to the results of the current study, the levels of LDL and FBS were high among the male cases with H. pylori infection. However, in females with H. pylori infection the level of TG was low; hence, it seems that the atherogenicity of H. pylori affected the level of blood sugar more.

The association of Helicobacter pylori infection with serum lipid profiles: An evaluation based on a combination of meta-analysis and a propensity score-based observational approach

“…Among such extragastric disorders, an effect of H. pylori on the lipid profile is one of the most important concerns, especially when considering the very high prevalence of H. pylori infection and dyslipidemia all over the world [8]. In recent years, several studies have reported that H. pylori infection is associated with the serum lipid profile [9][10][11], but these findings are considered controversial. Concerning the association between H. pylori infection and serum lipid profile, we speculate several mechanisms may be responsible for changes in blood lipid regulation.…”

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

“…Complex pathomechanisms may be involved in the relationship between H. pylori and cortical thinning. Increased metabolic syndrome [43][44][45][46] and vascular disorders [2] due to H. pylori infection were previously suggested [47,48]. Others suggested the chronic in ammation induced by persistent H. pylori infection could produce CRP and proin ammatory cytokines [49] that could directly damage neurons or activate neuroin ammatory cascades leading to Alzheimer's disease [9].…”

Eradication of Helicobacter pylori infection decreases risk for dyslipidemia: A cohort study

“…An experimental study showed that H. pylori ‐infected mucosa produced interleukin‐8 in levels exceeding the normal range 36 . Production of interleukin‐8 in H. pylori infection results in mucosa stimulation by oxidized LDL and monocytes, which subsequently increases the immigration of T lymphocytes to smooth muscle cells 37,38 . An in vitro study showed that H. pylori can increase cholesterol absorption from egg yolk and serum, indicating that cholesterol binding to H. pylori can reduce the absorption of dietary cholesterol 38,39 .…”

“…Production of interleukin‐8 in H. pylori infection results in mucosa stimulation by oxidized LDL and monocytes, which subsequently increases the immigration of T lymphocytes to smooth muscle cells 37,38 . An in vitro study showed that H. pylori can increase cholesterol absorption from egg yolk and serum, indicating that cholesterol binding to H. pylori can reduce the absorption of dietary cholesterol 38,39 . Therefore, further research is needed to clarify the mechanisms underlying the role of H. pylori in the pathogenesis of dyslipidemia.…”