Effect of Helicobacter pylori Infection Combined with CagA and Pepsinogen Status on Gastric Cancer Development among Japanese Men and Women: A Nested Case-Control Study

Abstract

Background: Although accumulating evidence suggests that Helicobacter pylori plays a role in gastric carcinogenesis, the magnitude of the risk remains uncertain. Aim: We aimed to estimate the magnitude of the risk of gastric cancer associated with H. pylori infection by a large case-control study nested within a prospective cohort. Possible effect modification by CagA status, and serum pepsinogen status, as a marker of atrophic gastritis, was also considered to see its effect on developing gastric cancer. Subjects and Methods: Subjects (n = 123,576) were followed up from 1990 to 2004; 511 gastric cancer cases matched to 511 controls were used in the analysis. Plasma immunoglobulin G antibody to H. pylori, CagA, and pepsinogen I and II were measured.

No associations of Toll-like receptor 2 (TLR2) -196 to -174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese

“…The validated criterion is PG I 70 ng/ml or less and a PG I/PG II ratio of 3.0 or less, and that for severe atrophic gastritis is PG I 30 ng/ml or less and a PG I/PG II ratio of 2.0 or less, both of which are assumed to be reliable because they are widely used in practice in Japan [31,32]. H. pylori seropositivity and PG levels were not examined in the gastric cancer cases in this study, based on the assumption that most of the gastric cancer cases would be H. pylori-positive with atrophic gastritis [33,34]. Considering that the intestinal type of gastric cancer, the predominant type of gastric cancer in Japan, arises from gastric atrophy caused by H. pylori infection, and diffuse-type gastric cancer occurs regardless of gastric atrophy [35,36], and noncardia gastric cancer is associated with H. pylori infection and gastric atrophy while cardia gastric cancer is not [37], it would be intriguing to perform subgroup analysis according to these two histological types or tumor locations.…”

No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese

“…The validated criterion for atrophic gastritis is PG I 70 ng/ml or less and a PG I/II ratio of 3.0 or less, and that for severe atrophic gastritis is PG I 30 ng/ml or less and a PG I/II ratio of 2.0 or less, both of which are presumed to be reliable because they are widely used in practice in Japan [36,37]. The H. pylori seropositivity and PG levels were not examined in the gastric cancer cases in this study, based on the assumption that most of the gastric cancer cases would be H. pylori-positive with atrophic gastritis [21,38]. Considering that the intestinal type of gastric cancer, the predominant type of gastric cancer in Japan, arises from gastric atrophy caused by H. pylori infection, and the diffuse type of gastric cancer occurs regardless of gastric atrophy [39,40], and noncardia gastric cancer is associated with H. pylori infection and gastric atrophy, while cardia gastric cancer is not [41], it would be intriguing to perform a subgroup analysis according to these two histological types or tumor locations.…”

Association between Acute Coronary Syndrome and Helicobacter Pylori Chronic Infection? What data mining tells us?

“…In order to describe the involvement of H. pylori in the development of CHD, it is necessary to find the largest number of reliable research studies; big data confirming this relationship. For our knowledge there is no study have used data mining analysis of such big data related ACS and Pylori, that artificial intelligence of Rapid I used in the current study can find the accurate or possible situation associations, hence according to our results only ACS of long duration of intermittent typical chest pain may becaused by Pylori chronic infection [8][9][10][11][12][13][14][15][16][17][18][19][20]. Data mining is the breakthrough in economy, biology, trading, business, astronomy and medicine [21][22][23].…”